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Leonhard Schnittger Jürgen May Christina Kretschmer Peter G. Kremsner C. G. Meyer 《Immunogenetics》1996,44(5):405-406
The nucleotide sequence data reported in this paper have been submitted to the EMBL nucleotide sequence database and have
been assigned the accession number X96986. The nameDPB1
*
6601 was officially assigned by the WHO Nomenclature Committee in May 1996. This follows the agreed policy that, subject to the
conditions stated in the most recent Nomenclature Report (Bodmer et al. 1995), names will be assigned to new sequences as
they are identified. Lists of such sequences will be published in the following WHO Nomenclature Report 相似文献
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Genetic and physical interactions between DPB11 and DDC1 in the yeast DNA damage response pathway 总被引:1,自引:0,他引:1
DPB11 is essential for DNA replication and S/M checkpoint control in Saccharomyces cerevisiae. The Dpb11 protein contains four BRCT domains, which have been proposed to be involved in protein-protein interactions. To further investigate the regulation and function of Dpb11, a yeast two-hybrid screen was carried out to identify proteins that physically interact with Dpb11. One positive clone isolated from the screen encoded a carboxyl-terminal fragment of Ddc1 (339-612 aa). Ddc1 is a DNA damage checkpoint protein, which, together with Mec3 and Rad17, has been proposed to form a PCNA-like complex and acts upstream in the DNA damage checkpoint pathways. We further determined that the carboxyl region of Dpb11 is required for its interaction with Ddc1. DDC1 and DPB11 also interact genetically. The Deltaddc1 dpb11-1 double mutant is more UV and MMS sensitive than the Deltaddc1 or the dpb11-1 single mutants. Furthermore, the double mutant is more hydroxyurea sensitive and displayed a lower restrictive temperature than dpb11-1. These results suggest that DPB11 and DDC1 may function in the same or parallel pathways after DNA damage and that DDC1 may play a role in responding to replication defects. 相似文献
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Shinichi Ishioka Soichiro Hozawa Kenji Hasegawa Toshifumi Saito Masatoshi Takaishi Michio Yamakido 《Biotherapy》1993,6(1):19-23
Eight patients with diffuse panbronchiolitis (DPB) who had repeated intractable airway infections were continuously treated withNocardia rubra cell wall skeleton (N-CWS), a biological response modifier. As a result, subjective symptoms were reduced in 6 patients. Antibiotics therapy could be discontinued completely in two patients and the dose of antibiotics could be reduced considerably in two other patients. No adverse reactions in relation to N-CWS were observed. These results suggest that N-CWS is effective in treating erythromycin-resistant DPB.Abbreviations BRM
Biological response modifier
- DPB
Diffuse panbronchiolitis
- EM
erythromycin
- N-CWS
Nocardia rubra cell wall skeleton 相似文献
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Correlation analysis of the HLA‐DPB1*05:01 and BTNL2 genes within the histocompatibility complex region with a clinical phenotype of psoriasis vulgaris in the Chinese Han population 下载免费PDF全文
Huimin Guo Yong Huang Juan Wu Xiaodong Zheng Lei Ye Hequn Huang Wenjun Wang Qi Zhen Jing Wu Wenjun Qian Hui Cheng Xing Fan Xuejun Zhang 《The journal of gene medicine》2017,19(9-10)
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Hiroshi Furukawa Shomi Oka Aya Kawasaki Kota Shimada Shoji Sugii Takashi Matsushita Atsushi Hashimoto Akiko Komiya Naoshi Fukui Kouji Kobayashi Atsumu Osada Atsushi Ihata Yuya Kondo Tatsuo Nagai Keigo Setoguchi Akiko Okamoto Akira Okamoto Noriyuki Chiba Eiichi Suematsu Hajime Kono Masao Katayama Shunsei Hirohata Takayuki Sumida Kiyoshi Migita Minoru Hasegawa Manabu Fujimoto Shinichi Sato Shouhei Nagaoka Kazuhiko Takehara Shigeto Tohma Naoyuki Tsuchiya 《PloS one》2016,11(4)
ObjectiveSeveral studies on associations between human leukocyte antigen (HLA) allele frequencies and susceptibility to systemic sclerosis (SSc) have been reported. Anti-centromere antibodies (ACA) and anti-topoisomerase I antibodies (ATA) are found in SSc patients. Here, we sought to identify HLA alleles associated with SSc in Japanese, and explored their associations with SSc phenotypes including the presence of autoantibodies.MethodsAssociations of HLA-DRB1, DQB1, and DPB1 were analyzed in 463 Japanese SSc patients and 413 controls.ResultsWe found that DRB1*13:02 (P = 0.0011, Pc = 0.0319, odds ratio [OR] 0.46, 95% confidence interval [CI] 0.29–0.73), DRB1*14:06 (P = 6.60X10-5, Pc = 0.0020, OR 0.05, 95%CI 0.01–0.41), DQB1*03:01 (P = 0.0009, Pc = 0.0150, OR 0.56, 95%CI 0.40–0.79), and DPB1*02:01 (P = 5.16X10-6, Pc = 8.77X10-5, OR 0.52, 95%CI 0.39–0.69) were protectively associated with SSc. In addition, these four alleles seemed to be independently associated with the protection against the susceptibility of SSc. On the other hand, we could not find predisposing alleles for overall SSc. With respect to SSc subsets, a tendency for these four alleles to be protectively associated was observed. However, there was a significant association between DRB1*01:01, DRB1*10:01, DQB1*05:01, and DPB1*04:02 and the susceptibility to SSc with ACA. On the other hand, the presence of DRB1*15:02, DQB1*06:01, DPB1*03:01, and DPB1*09:01 was associated with SSc with ATA.ConclusionThus, the present study has identified protective associations of the four HLA class II alleles with overall Japanese SSc and predisposing associations of HLA class II alleles with Japanese SSc subsets. 相似文献
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Major histocompatibility complex (MHC) molecules play an important role in the susceptibility and/or resistance to many diseases.
To gain an insight into the MHC background and to facilitate the experimental use of cynomolgus macaques, the second exon
of the MhcMafa-DOB, -DPB1, and -DQB1 genes from 143 cynomolgus macaques were characterized by cloning to sequencing. A total of 16 Mafa-DOB, 16 Mafa-DPB1, and 34 Mafa-DQB1 alleles were identified, which revealed limited, moderate, and marked allelic polymorphism at DOB, DPB1, and DQB1, respectively, in a cohort of cynomolgus macaques of Vietnamese origin. In addition, 16 Mafa-DOB, 5 Mafa-DPB1, and 8 Mafa-DQB1 alleles represented novel sequences that had not been reported in earlier studies. Almost of the sequences detected at the
DOB and DQB1 locus in the present study belonged to DOB*01 (100%) and DQB1*06 (62%) lineages, respectively. Interestingly, four, three, and one high-frequency alleles were detected at Mafa-DOB, -DPB1, and -DQB1, respectively, in this monkeys. The alleles with the highest frequency among these monkeys were Mafa-DOB*010102, Mafa-DPB1*13, and Mafa-DQB1*0616, and these were found in 33 (25.6%) of 129 monkeys, 32 (31.37%) of 102 monkeys, and 30 (31%) of 143 monkeys, respectively.
The high-frequency alleles may represent high priority targets for additional characterization of immune function. We also
carried out evolutionary and population analyses using these sequences to reveal population-specific alleles. This information
will not only promote the understanding of MHC diversity and polymorphism in the cynomolgus macaque but will also increase
the value of this species as a model for biomedical research. 相似文献
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Although the importance of the endosperm as a food store inmany angiosperm seeds is well known, its significance duringearly embryogenesis has been neglected. In many interspecifichybrids, and in some other situations, embryos do not developfully and abort. It has often been stated that this is causedby the endosperm failing to conduct sufficient nutrients tothe embryo, but seldom has it been suggested that the endospermactively controls most of the early stages of morphogenesisof the embryo. Information gleaned from a broad survey of theliterature, combined with additional evidence presented here,obtained fromSolanum incanumand interspecific hybrids, indicatethat the endosperm is dynamic and very active in regulatingearly embryo development. This requires highly integrated geneticcontrol of rapidly changing metabolism in the endosperm. Ininterspecific hybrids, lack of coordination may cause unbalancedproduction of growth regulating substances by the endospermand hence abortion of the embryo, or even unregulated productionof nucleases and proteases resulting firstly in autolysis ofthe endosperm and then digestion of the embryo. The endospermmay thus serve to detect inappropriate hybridization of speciesor ploidy levels and so prevent waste of resources by producingseeds that would result in sterile hybrids or unthrifty subsequentgenerations. This discriminatory function of the endosperm hasdiminished during evolution and domestication of the crop plantSolanummelongenaL.Copyright 1998 Annals of Botany Company Solanum, embryo morphogenesis, endosperm, hybrid, seed development. 相似文献
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Michele Rivkin-Flsh 《Medical anthropology quarterly》2000,14(1):119-120
Pragmatic Women and Body Politics. Margaret Lock and Patricia A. Kaufert. eds. Cambridge, UK: Cambridge University Press, 1998. xii +364 pp.
Maternities and Modernities: Colonial and Postcolonial Experiences in Asia and the Pacific. Kalpana Ram and Margaret Jolly. eds. Cambridge, UK: Cambridge University Press, 1998. xiv. 305 pp. 相似文献
Maternities and Modernities: Colonial and Postcolonial Experiences in Asia and the Pacific. Kalpana Ram and Margaret Jolly. eds. Cambridge, UK: Cambridge University Press, 1998. xiv. 305 pp. 相似文献