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Recent advances in the biochemistry of plant amines 总被引:1,自引:0,他引:1
Terence A. Smith 《Phytochemistry》1975,14(4):865-890
Simple aliphatic monoamines are formed in the red algae by a non-specific amino acid carboxy-lyase. An aldehyde-amino acid transaminase with broad substrate specificity is the mechanism for the formation of these amines in many higher plants. Putrescine accumulates in response to potassium and magnesium deficiency, and the amount of this diamine is greatly increased on supplying nitrogen as ammonium salts. Putrescine is also found at high levels in rapidly growing tissues. Cadaverine occurs in several leguminous plants. Putrescine, spermidine and spermine have been detected in many different species of plants, and they are probably ubiquitous. The polyamines are probably synthesized in plants by the pathways already demonstrated in animals and micro-organisms. Several new polyamine alkaloids have been characterized. Amine oxidases are probably involved in the formation of nicotine and indol-3yl-acetic acid. The amine oxidases from the Leguminosae and Gramineae have been further characterized. Carboxy-lyases have been demonstrated for tryptophan, tyrosine and DOPA. Cacti contain a large variety of phenethylamine derivatives related to mescaline. 相似文献
3.
《Plains anthropologist》2013,58(90):297-310
AbstractThe identity, origin, use and relationship of Peyote or Peyote buttons and mescal, mescal buttons, mescalbeans or mescaline continue to be confused. This paper examines the history of the confusion and uses ethnohistorical data to clarify the situation. Although Peyote, Lophophora williamsii and mescalbean, Sophora secundiflora, share the same general growth area, mostly in Mexico, the Spanish and Mexican reports on Peyote use are ancient and numerous, while nothing has been written about the use of mescalbeans south of the border. The use of the term mescalbean to refer to the red seed of Sophora secundiflora did not appear in print until 1914. A recent study shows that the greatest use of mescalbeans has been as beads. The paper concludes that theorists have inflated the importance of the relationship between mescalbeans and Peyote. 相似文献
4.
Charles I. Abou-Chaar 《Economic botany》1967,21(4):367-370
Lebanese-grown seed ofLupinus termis Forsk, was found to contain 2.075–2.34% of total alkaloids calculated as lupanine on the basis of the whole nondefatted seed and 9.19–9.36% of fat. Besides (±) lupanine, known to be the alkaloid ofL. termis seed, the seed was found to contain 13-hydroxylupanine in a small amount and four, possibly six, other unidentified alkaloids in small or trace quantities. 相似文献
5.
The amounts of two purine alkaloids, caffeine and theobromine,in the fruit of tea (Camellia sinensis L.) increased markedlyduring the growing season until the fruit was full-ripened anddried. In the dry fruit, the pericarp contained the most alkaloids,but there were also considerable amounts in the seed coat and,to a lesser extent, the fruit stalk and the seed. The shed seedsalso contained significant amounts of the alkaloids, especiallyin the seed coats. In contrast with the dry fruit of tea, seedsand pericarp of coffee (Coffea arabica L.) fruit contained aconsiderable amount of caffeine and a small amount of theobromide.A small amount of theophylline was also present in the pericarpof the ripened fruit. Relationships between growth and purinealkaloid content in tea and coffee fruits and their roles duringseed formation are discussed. Camellia sinensis L., tea, Coffea arabica L., coffee, purine alkaloids, fruit development, seed, seed coat, caffeine, theobromine, theophylline 相似文献
6.
Kokusaginine and evolitrine are the major alkaloids present in Sri Lankan Acronychia pedunculata. The Indian variety of Acronychia laurifolia collected in Madras does not contain these alkaloids. 相似文献
7.
We have established Catharanthus roseus hairy root cultures transgenic for the rol ABC genes from T(L)-DNA of the agropine-type Agrobacterium rhizogenes strain A4. The rol ABC hairy root lines exhibit a wild-type hairy root syndrome in terms of growth and morphology on solid medium. However, they differ from wild-type hairy root lines in that they more frequently have excellent adaptability to liquid medium and do not appear to form calli during cultivation. Moreover, they do not produce detectable levels of mannopine and agropine which, in contrast, are often synthesized abundantly in wild-type hairy root lines. The absence of these opines does not appear to cause the rol ABC lines to have higher levels of terpenoid indole alkaloids than wild-type hairy root lines. Unlike wild-type lines, rol ABC lines produce very similar levels of total alkaloids despite wide variations in individual alkaloid contents. This work demonstrates that the three genes rol ABC are sufficient to induce high-quality hairy roots in Catharanthus roseus. 相似文献
8.
Oreina elongata is a chemically defended leaf beetle. If its food plant contains pyrrolizidine alkaloids, all life stages of the beetle sequester them. However, one of the two known host-plant genera does not contain these alkaloids. In this paper we compare the adult feeding preference and larval performance of two populations, one feeding on Adenostyles alliariae (which contains alkaloids) and one on Cirsium spinosissimum (devoid of alkaloids). Adults of the population living on C. spinosissimum preferred the alkaloid-containing A. alliariae, while adults of the population feeding on A. alliariae showed no preference for either plant. On the other hand, larval growth of both populations is better on C. spinosissimum, without alkaloids. This is especially so in the population that never naturally encounters pyrrolizidine alkaloids; the population living on A. alliariae is apparently better adapted to its host's secondary compounds. The data are discussed in terms of cost of defense and trade-offs between growth and defense. 相似文献
9.
Interacciones Planta‐Nodriza en Lophophora diffusa (Cactaceae) en un Desierto Subtropical de México1
One of the two species from the genus Lophophora is the false peyote Lophophora diffusa, an endemic cactus species of the xerophytic shrubland at Querétaro, México, considered threatened from illegal extraction due to its hallucinogenic and medicinal properties. We analyzed the spatial distribution of L. diffusa and its association with the locally dominant shrub species with the system SADIE (Spatial Analysis by Distance IndicEs). We also studied the principal microclimatic factors (light, temperature, and humidity) beneath the canopy of the possible nurse plant species. The use of SADIE is a new approach to study the mechanisms of spatial distribution. Lophophora diffusa and the shrub species presented an aggregated distribution with patches and gaps, as indicated by the values of Ia= 4.179 for L. diffusa and Ia= 1.660 for the vegetation. Lophophora diffusa was positively associated with the arboreal vegetation, particularly with Larrea tridentata and Acacia sororia, but was negatively associated with Celtis pallida and Myrtillocactus geometrizans. Microclimate evaluation indicated that C. pallida canopy significantly reduced radiation and temperature compared to the other species (L. tridentata, A.sororia y P. laevigata). We had expected L. diffusa to exhibit a positive spatial association with C. pallida; however, the reduction in light availability apparently limited seedling establishment of L. diffusa. 相似文献
10.
Prior to the discovery of peyote, many American Indian tribes of the Southwest apparently used seeds of the Texas Mountain Laurel. The seeds are commonly referred to as “mescal beans,” “red beans,” and “dry whiskey,” and were utilized by the Indians to induce visions and serve as a divinatory medium for various ceremonial purposes. Indications that this material is a part of the modern drug scene prompted studies in which the three major alkaloids from this plant (cytisine, sparteine, and methylcytisine) were compared with a variety of known psychoactive compounds [N, N-dimethyltryptamine (DMT), mescaline, psilocybin, amphetamine, Δ9 - tetrahydrocannabinol (THC), and pentobarbital] to determine whether similarities in behavioral effects exist. Rats were tested for gross locomotor activity, locomotor activity pattersn (“pauses” and “bursts”), locomotor skill (rotorod testing), and conditioned avoidance response. A Duncan's Multiple Range Comparison of all of the drugs at several dose levels of each revealed that the alkaloids produced responses similar to the responses produced by the known hallucinogenic drugs (mescaline, DMT, psilocybin) and clearly dissimilar to normal saline, amphetamine, pentobarbital, and THC. 相似文献
11.
G L Vavilova O V Kirsenko V I Nazarenko O M Rozhmanova Z M Datsenko 《Ukrainski? biokhimicheski? zhurnal》1981,53(5):42-48
The content and composition of phospholipids is determined in beef microsomal and synaptosomal fractions and also in these fractions preparations solubilized with triton X-100 (0.1%) and digitonin (0.2%). It is shown that the microsomal fraction is richer in phospholipids. The solubilized fragments of microsomes have less or the same amount of phospholipids per protein unit than the initial fraction of microsomes, and the solubilized fragments of synaptosomes contain a higher quantity of phospholipids than the initial fraction. The content of phospholipids in "the riton" fragments of synaptosomes is higher than in "those" of microsomes. Contrary to digitonin which solubilizes the active Na+, K+-ATPase complex of microsomes and synaptosomes, triton X-100 solubilizes the active enzyme of microsomes only. A higher total content of phospholipids in "the triton" extracts of synaptosomes does not probably correlate with the presence of Na+, K+-ATPase activity in them. But these extracts are found to contain less phosphatidylserine whose addition recovers Mg2+, Na+, K+-ATPase activity in them. The effect of phosphatidylserine is not strictly specific for "the triton" extracts of synaptosomes, this lipid activates to a definite extent the extracts of microsomes as well. It is shown that at the first stages of bull brain Na+, K+-ATPase purification the total content of phospholipids and cholesterol in the preparations increases but the composition of phospholipids remains unchanged. 相似文献
12.
P.B. Danielson J.A. Letman J.C. Fogleman 《Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology》1995,110(4):683-688
The cytochrome P-450 family of enzymes is the primary means of foreign compound detoxification in virtually all organisms. Cytochrome P-450s have been strongly implicated in the metabolism of cactus alkaloids, and consequently, the observed patterns of host plant utilization by cactophilic species of Drosophila in the Sonoran Desert. The current study looked for evidence of alkaloid-metabolizing P-450 enzymes in a non-cactophilic species, D. melanogaster. The results of in vitro metabolism assays indicate the presence of a phenobarbital-inducible P-450 in adult D. melanogaster which is capable of metabolizing alkaloids. P-450 quantification data suggest that the enhanced level of metabolism is not the result of an overall increase in total P-450 content. Results from larval viability and adult longevity studies indicate that D. melanogaster's in vitro activity does not produce an enhanced in vivo tolerance of alkaloids. 相似文献
13.
Georgieva L Berkov S Kondakova V Bastida J Viladomat F Atanassov A Codina C 《Zeitschrift für Naturforschung. C, Journal of biosciences》2007,62(9-10):627-635
Leucojum aestivum (summer snowflake) is a plant species used for the extraction of galanthamine, an acetylcholinesterase inhibitor for the treatment of Alzheimer's disease. Extracts from bulbs collected from 18 Bulgarian populations and from shoot-clumps obtained in vitro from 8 different populations showed variations in their alkaloid composition. Nineteen alkaloids were detected in the studied samples by GC-MS. Typically, the alkaloid fractions of L. aestivum bulbs were dominated by galanthamine type compounds, but lycorine, haemanthamine and homolycorine type alkaloids were also found as dominant compounds in some of the samples. Extracts from the shoot-clumps obtained in vitro were found to contain galanthamine or lycorine as main alkaloids. The galanthamine content ranged from 28 to 2104 microg/g dry weight in the bulbs, and from traces to 454 microg/g dry weight in the shoot-clumps. 相似文献
14.
Nandkumar S. Shah O. D. Dulati D. A. Powell Vicki Kleinburd 《Neurochemical research》1977,2(3):265-279
Albino rabbits of either sex were anesthetized, and a cannula was implanted permanently into the lateral ventricle. About 1 week later, the distribution of [14C]mescaline and its deaminated metabolite, [14C]trimethoxyphenylacetic acid ([14C]TMPA) in 12 brain regions was examined at 15, 60, and 180 min after the intraventricular injection of [14C]mescaline (0.5 mol in 0.05 ml saline).14C-radioactivity was rapidly distributed in all regions, reaching peak levels within 15 min. The spinal cord, superior colliculus, pons, hypothalamus, caudate, medulla oblongata, and inferior colliculus contained 23–57 nmol/g of mescaline; the thalamus, tegmentum, and cerebellum, 12–15 nmol/g; and the cerebrum and hippocampus, less than 10 nmol/g; the levels of [14C]TMPA ranged from 0.5 to 5 nmol/g. The levels of [14C]mescaline and of [14]TMPA in all brain areas were considerably decreased 180 min after its injection. Pretreatment with chlorpromazine (15 mg/kg, i.p., 30 min) lowered [14C]mescaline concentrations in the hippocampus, caudate, thalamus, and cerebrum and elevated them in the spinal cord, medulla oblongata, pons, and tegmentum; [14C]TMPA levels as the percentage of total radioactivity were not affected. Pretreatment with iproniazid (150 mg/kg, i.p., 18 h), on the other hand, uniformly reduced the TMPA levels in all brain areas, with the resultant increases in mescaline levels. The CPZ-effect in lowering the mescaline concentrations in the areas belonging to the limbic system may have significance in explaining its antihallucinogenic effect in humans and its ability to block the altered behavior induced by the latter drug in laboratory animals. 相似文献
15.
Asexual embryos of Theobroma cacao L. cultured in a liquid medium on a rotary drum apparatus were induced to produce storage lipids, anthocyanin, and alkaloids by increasing concentration of sucrose but not glucose, and only slightly by fructose or fructose + glucose at the same osmolarity. Glucose combined with sucrose or alternating with sucrose reduced lipid concentration as compared to sucrose alone. The concomitant development of lipids, anthocyanin, and alkaloids suggests that sucrose at high concentration regulates the initiation of embryo development. 相似文献
16.
A reverse-phase high-performance liquid chromatography method utilizing evaporative light scattering detection (ELSD) has been developed for the simultaneous detection of hepatotoxic pyrrolizidine alkaloids with and without chromophores, namely, riddelliine, riddelliine N-oxide, senecionine, senecionine N-oxide, seneciphylline, retrorsine, integerrimine, lasiocarpine and heliotrine. Pyrrolizidine alkaloids were detected in five plant extracts (Senecio spartioides, S. douglasii var. longilobus, S. jacobaea, S. intergerrimus var. exaltatus and Symphytum officinale). The detection of heliotrine (which does not contain a chromophore) was much improved by ELSD compared with photodiode array detection. 相似文献
17.
Narberhaus I Theuring C Hartmann T Dobler S 《Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology》2003,173(6):483-491
Several Longitarsus flea beetle species sequester pyrrolizidine alkaloids acquired from their Asteraceae and Boraginaceae host plants. We carried out feeding and injection experiments using radioactively labeled pyrrolizidine alkaloids to investigate the physiological mechanisms of uptake, metabolism and storage of alkaloids in adult beetles. We examined six Longitarsus species belonging to different phylogenetic clades in a comparative approach. All species that accepted pyrrolizidine alkaloids in a preceding food choice study showed the ability both to store pyrrolizidine alkaloid N-oxides and to metabolize tertiary pyrrolizidine alkaloids into their N-oxides. Regardless of whether the beetles' natural host plants contain pyrrolizidine alkaloids or not, these species were found to possess an oxidizing enzyme. This oxygenase appears to be specific to pyrrolizidine alkaloids: [3H]Atropine and [14C]nicotine, two alkaloids not related to pyrrolizidine alkaloids, were neither stored nor N-oxidized by any of the tested species. One species, L. australis, that strictly avoids pyrrolizidine alkaloids behaviorally, exhibited a lack of adaptations to pyrrolizidine alkaloids on a physiological level as well. After injection of tertiary [14C]senecionine, beetles of this species neither N-oxidized nor stored the compounds, in contrast to L. jacobaeae, an adapted species that underwent the same treatment. L. jacobaeae demonstrated the same efficiency in N-oxidation and storage when fed or injected with tertiary [14C]senecionine.Communicated by G. Heldmaier 相似文献
18.
2-Methyl-1,2,3,4-tetrahydro-β-carboline was isolated from reed canarygrass (Phalaris arundinacea L.) and the occurrence of 2-methyl-6-methoxy-1,2,3,4-tetrahydro-β-carboline confirmed. Clones of reed canarygrass that contained N,N-dimethyltryptamine or 2-methyl-1,2,3,4-tetrahydro-β-carboline did not contain their respective methoxy or hydroxy derivatives. Five of the 12 clones tested contained either or both of 5-methoxy-N,N-dimethyltryptamine and 2-methyl-6-methoxy-1,2,3,4-tetrahydro-β-carboline. The data suggest that clones that contain gramine are not likely to contain N,N-dimethyltryptamine and/or β-carbolines. Thus, an inverse biosynthetic relationship between gramine and the tryptamine and β-carboline alkaloids seems to exist. However, further work is needed to firmly establish any such relationship between these alkaloids. 相似文献
19.
Hans-Joachim G. Jung George O. Batzli David S. Seigler 《Biochemical Systematics and Ecology》1979,7(3):203-209
Ninety-one species of arctic tundra plants were screened for possible chemical defences against herbivory. Tannins were found in one-third of the species, whereas two-thirds of the plants contained alkaloids. Anthraquinones, cyanogenic glycosides and saponins accounted for only 6% of the positive reactions. The results were used to test the apparency hypothesis for the distribution of chemical plant defences which states that rare or unpredictable species should contain qualitative defences (toxins, such as alkaloids) while common or predictable species should contain quantitative defences (digestibility-reducing compounds, such as tannins). Abundance of plant species showed no relationship to chemical content, except that the relatively abundant shrubs more often contained tannins than the relatively rare forbs. Common graminoids (grasses and related taxa) did not contain tannins and data for the other classes of compounds did not support the apparency hypothesis. Graminoids appeared to rely on tolerance to grazing rather than chemical defences and common ericaceous plants produced both digestibility-reducing and toxic compounds. 相似文献
20.
Jorge Mansur Medina Juliany Cola Fernandes Rodrigues Otacilio C Moreira Geórgia Atella Wanderley de Souza Hector Barrabin 《Memórias do Instituto Oswaldo Cruz》2015,110(1):48-55
Phytomonas serpens are flagellates in the family Trypanosomatidae that parasitise the
tomato plant (Solanum lycopersicum L.), which results in fruits with low commercial
value. The tomato glycoalkaloid tomatine and its aglycone tomatidine inhibit the
growth of P. serpens in axenic cultures. Tomatine, like many other saponins, induces
permeabilisation of the cell membrane and a loss of cell content, including the
cytosolic enzyme pyruvate kinase. In contrast, tomatidine does not cause
permeabilisation of membranes, but instead provokes morphological changes, including
vacuolisation. Phytomonas treated with tomatidine show an increased accumulation of
labelled neutral lipids (BODYPY-palmitic), a notable decrease in the amount of
C24-alkylated sterols and an increase in zymosterol content. These
results are consistent with the inhibition of 24-sterol methyltransferase (SMT),
which is an important enzyme that is responsible for the methylation of sterols at
the 24 position. We propose that the main target of tomatidine is the sterols
biosynthetic pathway, specifically, inhibition of the 24-SMT. Altogether, the results
obtained in the present paper suggest a more general effect of alkaloids in
trypanosomatids, which opens potential therapeutic possibilities for the treatment of
the diseases caused by these pathogens. 相似文献