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1.
Zinc nutritional status and its relationships with hyperinsulinemia in obese children and adolescents 总被引:4,自引:0,他引:4
A perturbation of zinc metabolism has been noted in subjects with obesity. The present work intends to investigate whether
the zinc nutritional status is associated with hyperinsulinemia in obesity. A study was carried out in a group of obese children
and adolescents (n=23) and compared to a control group (n=21), both between 7 and 14 yr of age. Software analyzed diet information from 3-d food records. Body composition was evaluated
by body mass index (BMI), bioelectrical impedance, and skinfold measurements. Zinc nutritional status was evaluated by Zn
determination in plasma, erythrocyte, and 24-h urine, by atomic absorption spectrophotometry (λ=213.9 nm). Insulin was measured
by radioimmunoassay (Linco Res). Diets consumed by both groups had marginal concentrations of zinc. Zinc concentrations in
plasma and erythrocytes were significantly lower in the obese group. Urinary zinc excretion and serum insulin were significantly
higher in the same group, although the insulinemia and the parameters of zinc nutritional status were not significantly correlated.
As a result, considering that zinc is part of the synthesis and secretion of this hormone, an assessment is necessary of the
possible participation of the oligoelement in the mechanisms of insulin resistance, commonly present in obese patients. 相似文献
2.
Adriana S. Lima Bárbara R. Cardoso Silvia F. Cozzolino 《Biological trace element research》2010,133(1):20-28
Experimental and clinical studies have established that zinc metabolism is altered in individuals with Down syndrome (DS).
The present study intends to evaluate the nutritional status of zinc in children with DS by determining their biochemical
and dietary parameters. The investigation was carried out on a group of children with DS (n = 35) and compared with a control group (n = 33), both aging between 4 and 11 years. Weight-for-age, height-for-age, and weight-for-height indexes and diet were evaluated
by using a 3-day dietary record. Zinc was evaluated in plasma, erythrocytes, and 24-h urine collection by using the method
of atomic absorption spectroscopy. The frequency of short stature was higher in children with DS. Both groups presented high
protein content, adequate concentrations of lipids and carbohydrates, and deficit in calories. Adequate zinc intake was observed
in 40% of children with DS and in 67% of the control group. Zinc concentrations were significantly lower in plasma and urine
and higher in erythrocytes of children with DS. The results allowed us to conclude that the altered zinc nutritional status
of individuals with Down syndrome contributes to clinical disturbances that usually appear with aging in these patients. 相似文献
3.
Marques RC de Sousa AF do Monte SJ Oliveira FE do Nascimento Nogueira N Marreiro DN 《Biological trace element research》2007,120(1-3):11-18
Studies have evidenced that zinc metabolism is altered in presence of Down syndrome, and zinc seems to have a relationship
with the metabolic alterations usually present in this syndrome. In this work, the Zn-related nutritional status of adolescents
with Down syndrome was evaluated by means of biochemical parameters and diet. A case–control study was performed in a group
of adolescents with Down syndrome (n = 30) and a control group (n = 32), of both sexes, aged 10 to 19 years. Diet evaluation was accomplished by using a 3-day dietary record, and the analysis
was performed by the NutWin program, version 1.5. Antropometric measurements were performed for evaluation of body composition.
The Zn-related nutritional status of the groups was evaluated by means of zinc concentration determinations in plasma and
erythrocytes, and 24-h urinary zinc excretion, by using the method of atomic absorption spectroscopy. The diet of both groups
presented adequate concentrations of lipids, proteins, carbohydrates, and zinc. The mean values found for zinc concentration
in erythrocytes were 49.2 ± 8.5 μg Zn/g Hb for the Down syndrome group and 35.9 ± 6.1 μg Zn/g Hb for the control group (p = 0.001). The average values found for zinc concentration in plasma were 67.6 ± 25.6 μg/dL for the Down syndrome group and
68.9 ± 22.3 μg/dL for the control group. The mean values found for zinc concentration in urine were 244.3 ± 194.9 μg Zn/24 h
for the Down syndrome group and 200.3 ± 236.4 μg Zn/24 h for the control group. Assessment of body composition revealed overweight
(26.7%) and obesity (6.6%) in the Down syndrome group. In this study, patients with Down syndrome presented altered zinc levels
for some cellular compartments, and the average zinc concentrations were low in plasma and urine and elevated in erythrocytes. 相似文献
4.
de Sena KC Arrais RF das Graças Almeida M de Araújo DM dos Santos MM de Lima VT de Fãtima Campos Pedrosa L 《Biological trace element research》2005,105(1-3):1-9
The purpose of this study was to identify the effect of oral zinc supplementation in patients with type 1 diabetes (T1DM)
on metabolic control and zinc blood concentrations. The sample consisted of 20 patients with T1DM and a control group (n=17). Metabolic control was evaluated by glycemia at fast, 24 h glycosuria, and HbA1c. Zinc concentrations were measured in
plasma and erythrocytes. After the first collection of biological material, oral zinc supplementation was initiated and continued
for 4 mo in T1MD patients (T1). Daily dosages were established based on Dietary Recommended Intakes (DRIs), considering zinc
intake based on data from other studies previously performed with this population. All analyses were repeated after supplementation
(T2). Metabolic control was unsatisfactory, with an HbA1c increase at T2. There was no difference in zinc concentrations in
plasma and erythrocytes between patients with T1DM and control. Zinc concentrations in plasma were within the normal range
in T1MD before and after supplementation and the control. Zinc concentrations in erythrocyte presented lower than normal values
for all groups. A zinc increase in erythrocyte after supplementation was observed in T1DM patients, although without statistical
significance. More studies are needed to confirm oral zinc supplementation as nutritional management in diabetes. 相似文献
5.
Karla de Jesus Fernandes de Oliveira Carmen Marino Donangelo Astrogildo Vianna de Oliveira Jr. Carmen Lucia Porto da Silveira Josely Correa Koury 《Cell biochemistry and function》2009,27(3):162-166
Puberty associated with intense physical activity results in oxidation stress. Zinc supplementation may benefit antioxidant capacity although it may also affect iron and copper status. This study evaluated the effect of zinc supplementation on antioxidant, zinc and copper status of physically active male football players (13 years ± 0.4 years), divided in two groups and studied during 12 weeks: Zn‐supplemented (Zn‐SUP, 22 mg Zn d?1 as zinc gluconate, n = 21) and placebo (PLA, n = 26). At baseline, there was no significant difference in biochemical indices between the two groups. After treatment, plasma zinc and erythrocyte iron increased in both groups (p < 0.001); urinary zinc increased (p < 0.001) only in Zn‐SUP, and erythrocyte zinc decreased (p = 0.002) only in PLA. Plasma iron and copper decreased (p = 0.01 and p = 0.015, respectively) only in Zn‐SUP. Plasma ferric‐reducing ability and plasma conjugated dienes increased, and erythrocyte osmotic fragility decrease in both groups, although the latter two were significantly lower in Zn‐SUP compared to PLA (p < 0.01). In conclusion, our study indicates that the use of 22 mg d?1 of supplemental zinc during 12 week in adolescent athletes did not affect growth, improved markers of antioxidant status but reduced plasma iron and copper. Therefore, it appears that the use of zinc supplementation by healthy adolescent athletes benefits their antioxidant capacity but impairs copper and iron nutritional status. Copyright © 2009 John Wiley & Sons, Ltd. 相似文献
6.
da Costa GA do Nascimento Marreiro D Eulálio JM Neto JM Amorim AC Nogueira AM do Monte SJ Nogueira Ndo N 《Biological trace element research》2008,126(Z1):S15-S20
This study evaluated nutritional status linked to zinc levels in 239 randomly selected children at crèches in Teresina, Brazil, aged 3 to 6. Blood samples were collected after fasting of 10 h. Erythrocytary zinc levels were determined through flame atomic absorption spectrophotometry. Zinc deficiency was determined as below 40 microg Zn/g Hb. Infant linear growth was evaluated measuring weight and height, and nutritional status by height/age, weight/height, and weight/age indices, expressed as Z scores, in line with the National Center for Health Statistics. The mean zinc concentration was 35.50 +/- 10.95 microg Zn/g Hb. Zinc distribution in the 10, 50, 75, and 90 percentiles was 24.73 microg Zn/g Hb, 35.45 microg Zn/g Hb, 40.73 microg Zn/g Hb and 52.77 microg Zn/g Hb, respectively. Based on this distribution, normal values were found only from the 75th percentile and above. Since the cutoff point adopted was 40 microg Zn/g Hb, the prevalence of zinc deficiency was 74.3%. As for growth profile, 8.4% were chronically malnourished, although the statistical association between linear impairment and nutritional status regarding zinc was insignificant. The study revealed that an important segment of the infant population was mineral deficient; however, the degree of deficiency did not influence growth profiles. 相似文献
7.
Lima SC Arrais RF Sales CH Almeida MG de Sena KC Oliveira VT de Andrade AS Pedrosa LF 《Biological trace element research》2006,114(1-3):19-29
The aim of this study was to assess erythrocyte and plasma copper concentrations and correlate them with the lipid profile
of overweight and obese children and adolescents. The study was performed with 15 over-weight and 30 obese children and adolescents,
and the results were compared to the control group (21), aged 6–16 yr. Anthropometric assessment was carried out using body
mass index (BMI). Total cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol,
and triglyceride serum levels were investigated. Erythrocyte and plasma copper levels were determined by atomic absorption
spectrophotometry. Greater alterations in the lipid profile were observed in HDL-cholesterol, LDL-cholesterol, and triglyceride
levels, with distinctions according to gender. The plasma copper concentrations in the overweight and obese male groups were
significantly higher than those in the control group (p=0.0006). Negative correlations between plasma copper and total cholesterol (r=−0.54) and LDL cholesterol (r=−0.59) were observed in the obese male group. There was no statistical difference in copper erythrocyte concentrations. The
obesity associated to disorders in lipid metabolism predisposes to changes in copper plasma concentrations, but there was
no alteration in intracellular reserves, which suggests an important homeostatic control to compensate for plasma oscillations
and metabolic alterations of the disease. 相似文献
8.
Gildene Alves da Costa Dilina do Nascimento Marreiro Juliana Maria Libório Eulálio José Machado Moita Neto Amanda Castro Amorim Apolônia Maria Tavares Nogueira Semíramis Jamil Hadad do Monte Nadir do Nascimento Nogueira 《Biological trace element research》2008,126(1):15
This study evaluated nutritional status linked to zinc levels in 239 randomly selected children at crèches in Teresina, Brazil, aged 3 to 6. Blood samples were collected after fasting of 10 h. Erythrocytary zinc levels were determined through flame atomic absorption spectrophotometry. Zinc deficiency was determined as below 40 µg Zn/g Hb. Infant linear growth was evaluated measuring weight and height, and nutritional status by height/age, weight/height, and weight/age indices, expressed as Z scores, in line with the National Center for Health Statistics. The mean zinc concentration was 35.50?±?10.95 µg Zn/g Hb. Zinc distribution in the 10, 50, 75, and 90 percentiles was 24.73 µg Zn/g Hb, 35.45 µg Zn/g Hb, 40.73 µg Zn/g Hb and 52.77 µg Zn/g Hb, respectively. Based on this distribution, normal values were found only from the 75th percentile and above. Since the cutoff point adopted was 40 µg Zn/g Hb, the prevalence of zinc deficiency was 74.3%. As for growth profile, 8.4% were chronically malnourished, although the statistical association between linear impairment and nutritional status regarding zinc was insignificant. The study revealed that an important segment of the infant population was mineral deficient; however, the degree of deficiency did not influence growth profiles. 相似文献
9.
To know whether plasma zinc status is altered under acute hyperglycemic state, the interrelationships among plasma glucose,
insulin, and zinc concentrations during oral glucose tolerance test (OGTT) in obese individuals and their lean controls were
studied. Plasma glucose and insulin concentrations under fasting as well as those values in response to OGTT were significantly
higher in obese individuals than those in lean controls. On the other hand, the obese had lower fasting plasma zinc concentrations
compared to lean controls (13.5 vs 18.1 Μmol/L,p < 0.005). Under fasting, plasma zinc concentrations in overall individuals inversely correlated to their body mass index (BMI)
(r = -0.516), plasma glucose (r = -0.620), and plasma insulin (r = -0.510). However, there were no significant changes in plasma
zinc and copper values during OGTT in both obese individuals and lean controls. This study showed that plasma zinc values
had no changes during OGTT in obese individuals. The results also indicated that lower fasting plasma zinc concentrations
in obese individuals were not the short-term metabolic result. 相似文献
10.
Chih-Hung Guo Wang-Sheng Ko Pei-Chung Chen Guoo-Shyng W. Hsu Chia-Yeh Lin Chia-Liang Wang 《Biological trace element research》2009,131(1):13-24
The present study was conducted to compare the trace elements and oxidative status between uremic patients with and without
dementia. Chronic hemodialysis patients with dementia (n = 20) and without dementia (n = 25), and age-matched healthy volunteers (n = 20) were enrolled. The nutritional status, blood levels of trace elements aluminum (Al), zinc (Zn), copper (Cu), magnesium
(Mg) and iron (Fe), malondialdehyde (MDA), and protein carbonyl production, antioxidant enzymes glutathione peroxidase (GPx),
and glutathione reductase (GR) activities were measured. No significant difference in nutritional status or clinical characteristics
was observed between nondementia and dementia patients. However, uremic patients with dementia have significantly higher Al,
Cu, and Mg and lower Zn concentrations, as well as increased Cu/Zn ratio in comparison to nondementia patients. There were
statistically significant increased MDA and carbonyl production and decreased GPx and GR activities in dementia patients.
Furthermore, the significant associations of Al, Mg, and Cu/Zn ratio with oxidative status in patients with dementia were
noted. The dementia may initially worsen with abnormal metabolism of trace elements and oxidative stress occurrence. Our results
suggest that abnormalities in trace element levels are associated with oxidative stress and may be a major risk factor in
the dementia development of uremic patients. 相似文献
11.
Weisstaub G Hertrampf E López de Romaña D Salazar G Bugueño C Castillo-Duran C 《Biological trace element research》2007,118(2):167-174
Zinc (Zn) deficiency and obesity can be observed together in some developing countries. Zn deficiency may enhance fat deposition
and decrease lean mass accrual, which in turn, appears to influence physical activity (PA), although this has not yet been
evaluated in obese children. The objective of the study was to find out the association between measurements of plasma Zn
and serum leptin, body composition, and PA in Chilean obese preschool children. Seventy-two 18- to 36-month-old obese children
[weight-for-length/height z score (WHZ) > 2.0 SD], belonging to low socioeconomic communities, participated in the study. Plasma Zn, serum leptin, weight,
waist circumference, height, total body water (TBW) assessed by deuterium isotopic dilution technique and daily activity,
measured by registering 48 h with an accelerometer, were evaluated. We found 82% of children with WHZ > 3 SD. The geometric
mean Zn intake was 6.2 ± 2.5 mg/day. The mean plasma Zn was 91.8 ± 11.4 μg/dL, with 10% of the children having levels <80 μg/dL.
No correlation was found between plasma Zn concentrations and either weight, WHZ, or waist circumference. Serum leptin was
lower in males than in females (2.9 ± 2.8 vs 6.8 ± 5.0 ng/mL, respectively; p < 0.001). TBW was different between males and females (56.2 ± 5.4 vs 52.8 ± 4.3% body weight, respectively; p = 0.004), but no significant association was found between TBW and plasma Zn. Moderate + intense PA, (as percentage of wake
time), was greater in males than in females (6.3 ± 3.1% vs 3.4 ± 2.3%, respectively; p < 0.001), but it was not significantly correlated to plasma Zn. In conclusion, plasma Zn was not associated with body composition
as assessed by TBW, serum leptin, or with the magnitude of physical activity in Chilean overweight preschool children. 相似文献
12.
Lucianna Fernandes J. C. Marques Carmen Marino Donangelo Juliana Gastao Franco Luciane Pires Aderval Severino Luna Gustavo Casimiro-Lopes Patricia Cristina Lisboa Josely Correa Koury 《Biological trace element research》2011,142(3):415-423
Intense physical activity is associated with biological adaptations involving hormones and trace elements. Zinc supplementation
may affect plasma copper concentration, thyroid-stimulating hormone (TSH), thyroid hormones, insulin, and glucose homeostasis,
but data in athletes are scarce. The aim of this study was to evaluate in competitive athletes (cyclists, n = 7, 32 ± 8 years) the effect of zinc supplementation (22 mg/day as zinc gluconate) during 30 days, and discontinuation using
placebo (maltodextrin) during the following 30 days, on plasma zinc and copper concentrations, serum thyroid hormones, insulin
and glucose levels, and HOMA2-IR. Compared to baseline, plasma zinc and Zn:Cu plasma ratio increased, but plasma copper decreased
after zinc supplementation (day 30) and discontinuation (day 60) (p < 0.05). Zn supplementation and discontinuation had no effect on TSH, T3, and T4. Fasting serum insulin and HOMA2-IR increased
(27% and 47%, respectively) on day 60 compared to baseline (p = 0.03), suggesting a delayed effect of zinc supplementation. Moreover, plasma zinc was positively associated with serum
insulin (r = 0.87, p = 0.009) and HOMA2-IR (r = 0.81, p = 0.03) after zinc supplementation (day 30), indicating that supplemental zinc may impair glucose utilization in cyclists. 相似文献
13.
dos Santos Rocha PB de Castro Amorim A de Sousa AF do Monte SJ da Mata Sousa LC do Nascimento Nogueira N Neto JM do Nascimento Marreiro D 《Biological trace element research》2011,143(2):603-611
Research has investigated the participation of zinc transport proteins and metallothionein in the metabolism of this mineral.
However, studies about the genetic expression of these proteins in obese patients are scarce. The study determined the expression
of zinc transporter protein codifying genes (ZnT-1, Zip-1 and Zip-3) and of metallothionein in 55 obese women, aged between
20 and 56 years. The assessment of body composition was carried out using anthropometric measurements and bioelectrical impedance.
Zinc intake was obtained by recording diet over a 3-day period, and the nutritional analysis was carried out using NutWin
software version 1.5. The plasmatic and erythrocytary zinc were analyzed by atomic absorption spectrophotometry (λ = 213. 9 nm). The determination of mRNA expression of the zinc transporter proteins and metallothionein was carried out using
blood, using the RT-PCR method. The mean values of body mass index were 37.9 ± 5.5 kg/m2. The average intake of zinc was 9.4 ± 2.3 mg/day. The analysis of the zinc plasma concentrations showed values of 58.4 ± 10.9 μg/dL.
The mean values of zinc in the erythroytes were 38.7 ± 9.1 μg/g Hb. The metallothionein gene had a higher expression in the
blood, when compared to zinc transporters ZnT-1, Zip-1, and Zip-3 (p = 0.01). The study shows that there are alterations in the biochemical parameters of zinc in obese patients assessed, as
well as higher expression of the codifying gene metallothionein, when compared to the investigated zinc transporters. 相似文献
14.
Dilina do Nascimento Marreiro Artemizia Francisca de Sousa Nadir do Nascimento Nogueira Francisco Erasmo Oliveira 《Biological trace element research》2009,129(1-3):20-27
Studies have evidenced that zinc metabolism is altered in the presence of Down syndrome, and zinc seems to have a relationship with the metabolic alterations usually present in this syndrome. In this work, the effect of zinc supplementation on thyroid hormone metabolism was evaluated in adolescents with Down syndrome. A prospective study was carried out on 16 adolescents with Down syndrome (age: 10–19 years) who were randomized for treatment with 30 mg zinc daily for 4 weeks. Diet evaluation was accomplished y using a 3-day dietary record, and the analysis was performed by the NutWin program, version 1.5. Anthropometric measurements were performed for evaluation of body composition. The Zn-related nutritional status of the groups was evaluated by means of zinc concentration determinations in plasma and erythrocytes using the method of atomic absorption spectroscopy, and the thyroid hormone was obtained by radioimmunoassay. The diet of patients with Down syndrome, before and after the intervention presented reduced energy level and adequate zinc concentrations. Mean plasma zinc values were 59.2?±?13.2 and 71.0?±?21.9 μg/dL before and after the intervention, respectively. Erythrocyte concentrations of the mineral before supplementation, instead, were 51.5 μg/dL?±?11.1 μg Zn/gHb, and at the end of the experiment, they were 42.9?±?8/5 μg Zn/gHb, with a significant statistical difference (p?<?0.05). Serum concentrations of T4 hormone before and after zinc supplementation were 1.26?±?0.20 and 1.54?±?0.63 pg/mL, respectively. Mean T3 values before intervention were 2.47?±?037 pg/mL and, after supplementation, 2.25?±?0.67 pg/mL, without significant statistical difference (p?>?0.05). Intervention with zinc showed to be effective in the stabilization of the concentrations of this mineral in plasma and erythrocytes, but had no influence on the metabolism of thyroid hormones. 相似文献
15.
We investigated the possible correlation between the leptin concentration and the Zn/Cu ratio in the plasma of women with
thyroid disorder. Forty women with hypothyroidism (n=20) or hypothyroidism (n=20) and 20 euthyroid controls were recruited. The results showed that the women with thyroid disorder (hypothyroidism or
hyperthyroidism) had higher plasma leptin concentrations than the normal controls (p<0.05). Moreover, the plasma leptin concentration had no correlation with plasma thyroid hormone levels in the separate groups,
nor among all the participants considered together. A strong correlation (p<0.005) between leptin and adiposity was only observed in euthyroid women. Plasma values of Zn and Cu and the Zn/Cu ratio
were not markedly different among women with altered thyroid status. However, a weak correlation (r=0.28, p=0.032) between leptin and the Zn/Cu ratio was found from the pooled data of all participants and retained after adjustment
for adiposity. We suggest that there may exist an interaction between the plasma leptin level and thyroid hormone-induced
abnormality for selected minerals. 相似文献
16.
Fulya Tekşen Bekir Sitki Şayli Ahmet Aydin Ahmet Sayal Aşkin Işimer 《Biological trace element research》1998,63(2):123-127
Down syndrome is the most common cause of mental retardation, affecting 1 in 700–800 liveborn infants. Although numerous biochemical
abnormalities accompanying the syndrome have not yet been completely clarified, the antioxidant defense system enzymes have
shown to be altered due to increased gene dosage on chromosome 21 and overproduction of superoxide dismutase (SOD-1 or Cu/Zn
SOD). The purpose of this study was to investigate the activities of SOD-1 and glutathione peroxidase (GSH-Px) enzymes and
the levels of their cofactors zinc (Zn), copper (Cu) and selenium (Se) in plasma of 20 Down syndrome patients.
In comparison with age and sex-matched controls (n=15), plasma GSH-Px, SOD, and Cu levels were significantly decreased in the patient group, but Zn and Se concentrations remained
unchanged.
This study was presented as a poster in 29th Annual Meeting of European Society of Human Genetics held in Genoa in May, 1997. 相似文献
17.
The element Zn is the metal component or activator of many important enzymes. The tissue concentrations and activities of
Zn metalloenzymes direct the rate of protein and nucleic acid syntheses, thereby influencing tissue growth and reperative
processes. Most of the serum Zn is normally bound to circulating proteins. Low serum Zn concentrations might result from depletion
of Zn-binding proteins. Serum protein and Zn concentrations have been reported to be depressed in patients with acute and
chronic diseases. We compare the serum protein and Zn values of patients with thoracic empyema (n=20) with those of a control group (n=20). The values obtained in the empyema group were significantly lower than those in the control group before the study.
Test group administered 220 mg zinc sulfate (ZnSO4. 7H2O) over 20 d and there was a significant increase in the values for serum protein and Zn after the oral administration of
the zinc sulfate. 相似文献
18.
Erdogan M Ustüner I Cengiz B Söylemez F Cavdar AO 《Biological trace element research》2006,109(2):105-113
In this article, we report the results of a case control study carried out on 290 Turkish pregnant women at 5–24 wk of gestation
to determine their zinc, folic acid, and vitamin B12 levels in relation to their nutritional and socioconomic status. The women were divided into two groups (n=145 each), depending on the stage of gestation. Group I consisted of women in the first trimester of gestation; those in
the second trimester were allocated into group II. Twenty-five age-matched, healthy nonpregnant women were selected as controls.
The nutritional status of the subjects was determined by means of a survey. Based on this, the women were subdivided into
three subgroups: malnourished (PN), moderately nourished (MN), and well nourished (WN). Also from the survey, the socioeconomic
status was classified as good (G) or bad (B). A statistically significant decrease on zinc and folic acid was observed in
group I women, as their socioeconomic status worsened. In group II, zinc decreased only in the PN and MN subgroups, p<0.001. The folic acid and vitamin B12 levels did not change significantly during the second trimester of gestation in all subgroups. Regarding zinc, nutrition,
or dietary habits are more relevant than socioeconomic status, but poor nutrition affects folic acid levels only during the
first trimester of gestation. 相似文献
19.
Arvanitidou V Voskaki I Tripsianis G Athanasopoulou H Tsalkidis A Filippidis S Schulpis K Androulakis I 《Biological trace element research》2007,115(1):1-12
Zinc (Zn) and copper (Cu) are essential trace elements in people, being required for functional activity of several enzyme
systems. In this study, we determined Cu and Zn concentrations in the serum of 105 healthy children randomly selected, aged
3–14 yr, residing in a region of Greece (Thrace), and we investigated their association with children's gender, age, height,
weight, and nutritional habits. The mean levels of Zn and Cu were 15.01±2.95 μmol/L and 26.18±5.47 μmol/L, respectively, with
no significant difference between boys and girls. A significant positive correlation was found between age and Zn levels,
and a negative one was found between age and Cu levels. Both Zn and Cu levels tended to increase with height, whereas Zn levels
significantly decreased with increasing body mass indent (BMI). The consumption of meat, milk, and eggs were independent determinants
for higher Zn levels, and the consumption of legumes and fruits were independent determinants for higher Cu levels. A significant
negative correlation was found between Zn and Cu levels. In conclusion, our study, the first one evaluating the serum status
of Cu and Zn in healthy Greek children, identified significant correlations of Zn and Cu levels with their age, height, BMI,
and nutritional habits. 相似文献
20.
Marzec-Wróblewska U Kamiński P Lakota P Szymański M Wasilow K Ludwikowski G Kuligowska-Prusińska M Odrowąż-Sypniewska G Stuczyński T Michałkiewicz J 《Biological trace element research》2011,143(1):167-177
The aim of the present study was to measure zinc (Zn) and iron (Fe) concentration in human semen and superoxide dismutase
(SOD) activity in seminal plasma and correlate the results with sperm quality. Semen samples were obtained from men (N = 168) undergoing routine infertility evaluation. The study design included two groups based on the ejaculate parameters.
Group I (n = 39) consisted of males with normal ejaculate (normozoospermia), and group II (n = 129) consisted of males with pathological spermiogram. Seminal Zn and Fe were measured in 162 samples (group I, n = 38; group II, n = 124) and SOD activity in 149 samples (group I, n = 37; group II, n = 112). Correlations were found between SOD activity and Fe and Zn concentration, and between Fe and Zn concentration. SOD
activity was negatively associated with volume of semen and positively associated with rapid progressive motility, nonprogressive
motility, and concentration. Negative correlation was stated between Fe concentration and normal morphology. Mean SOD activity
in seminal plasma of semen from men of group I was higher than in seminal plasma of semen from men of group II. Fe concentration
was higher in teratozoospermic males than in males with normal morphology of spermatozoa in group II. Our results suggest
that Fe may influence spermatozoa morphology. 相似文献