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Jingyuan Zhang Tianyu Wang Ruona Shi Yuan Zhao Yanqi Zhang Cong Zhang Qi Xing Tiancheng Zhou Yongli Shan Hongjie Yao Xiaofei Zhang Guangjin Pan 《Journal of cellular physiology》2024,239(1):e31152
Polycomb repressive complexes (PRCs) play critical roles in cell fate decisions during normal development as well as disease progression through mediating histone modifications such as H3K27me3 and H2AK119ub. How exactly PRCs recruited to chromatin remains to be fully illuminated. Here, we report that YTHDF1, the N6-methyladenine (m6A) RNA reader that was previously known to be mainly cytoplasmic, associates with RNF2, a PRC1 protein that mediates H2AK119ub in human embryonic stem cells (hESCs). A portion of YTHDF1 localizes in the nuclei and associates with RNF2/H2AK119ub on a subset of gene loci related to neural development functions. Knock-down YTHDF1 attenuates H2AK119ub modification on these genes and promotes neural differentiation in hESCs. Our findings provide a noncanonical mechanism that YTHDF1 participates in PRC1 functions in hESCs. 相似文献
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Syam Prakash Somasekharan Neetu Saxena Fan Zhang Eliana Beraldi Jia
Ni Huang Christina Gentle Ladan Fazli Marisa Thi Poul
H Sorensen Martin Gleave 《Nucleic acids research》2022,50(2):1069
We report a new mechanism of androgen receptor (AR) mRNA regulation and cytoprotection in response to AR pathway inhibition (ARPI) stress in prostate cancer (PCA). AR mRNA translation is coordinately regulated by RNA binding proteins, YTHDF3 and G3BP1. Under ambient conditions m6A-modified AR mRNA is bound by YTHDF3 and translationally stimulated, while m6A-unmodified AR mRNA is bound by G3BP1 and translationally repressed. When AR-regulated PCA cell lines are subjected to ARPI stress, m6A-modified AR mRNA is recruited from actively translating polysomes (PSs) to RNA-protein stress granules (SGs), leading to reduced AR mRNA translation. After ARPI stress, m6A-modified AR mRNA liquid–liquid phase separated with YTHDF3, while m6A-unmodified AR mRNA phase separated with G3BP1. Accordingly, these AR mRNA messages form two distinct YTHDF3-enriched or G3BP1-enriched clusters in SGs. ARPI-induced SG formation is cell-protective, which when blocked by YTHDF3 or G3BP1 silencing increases PCA cell death in response to ARPI stress. Interestingly, AR mRNA silencing also delays ARPI stress-induced SG formation, highlighting its supportive role in triggering this stress response. Our results define a new mechanism for stress adaptive cell survival after ARPI stress involving SG-regulated translation of AR mRNA, mediated by m6A RNA modification and their respective regulatory proteins. 相似文献
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Xiao-Li Ping Bao-Fa Sun Lu Wang Wen Xiao Xin Yang Wen-Jia Wang Samir Adhikari Yue Shi Ying Lv Yu-Sheng Chen Xu Zhao Ang Li Ying Yang Ujwal Dahal Xiao-Min Lou Xi Liu Jun Huang Wei-Ping Yuan Xiao-Fan Zhu Tao Cheng Yong-Liang Zhao Xinquan Wang Jannie M Rendtlew Danielsen Feng Liu Yun-Gui Yang 《Cell research》2014,24(2):177-189
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RNA editing of Filamin A pre‐mRNA regulates vascular contraction and diastolic blood pressure
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Mamta Jain Shailaja P Rao Andrijana Kirsch Dieter Pullirsch Xué Strobl Claus Rath Lukas Reissig Kristin Moreth Tanja Klein‐Rodewald Raffi Bekeredjian Valerie Gailus‐Durner Helmut Fuchs Martin Hrabě de Angelis Eleonore Pablik Laura Cimatti David Martin Jelena Zinnanti Wolfgang F Graier Maria Sibilia Saša Frank Erez Y Levanon Michael F Jantsch 《The EMBO journal》2018,37(19)