共查询到20条相似文献,搜索用时 109 毫秒
1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
Eriko Iwata Norihito Nakamichi Takamasa Suzuki Poyu Chen Misato Ohtani Takashi Ishida Hanako Hosoya Sabine Müller Tünde Leviczky Aladár Pettkó‐Szandtner Zsuzsanna Darula Akitoshi Iwamoto Mika Nomoto Yasuomi Tada Tetsuya Higashiyama Taku Demura John H Doonan Marie‐Theres Hauser Keiko Sugimoto Masaaki Umeda Zoltán Magyar László Bögre Masaki Ito 《The EMBO journal》2015,34(15):1992-2007
11.
Permanent silencing of E2F-dependent genes is a hallmark of the irreversible cell cycle exit that characterizes terminally differentiated and senescent cells. The determinant of this silencing during senescence has been proposed to be the binding of the retinoblastoma protein Rb and the consequent methylation of H3K9. During ex vivo skeletal muscle differentiation, while most cells terminally differentiate and form myotubes, a subset of myoblasts remains quiescent and can be reinduced by growth factor stimulation to enter the cell cycle. Thus, differentiating cells are composed of two different populations: one in which E2F-dependent genes are permanently repressed and the other not. We observed that, in a manner reminiscent to senescent cells, permanent silencing of the E2F-dependent cdc6, dhfr, and p107 promoters in myotubes was associated with a specific increase in H3K9 trimethylation. To investigate the role of Rb in this process, we developed a reliable method to detect Rb recruitment by chromatin immunoprecipitation. Surprisingly, we observed that Rb was recruited to these promoters more efficiently in quiescent cells than in myotubes. Thus, our data indicate that during muscle differentiation, permanent silencing and H3K9 trimethylation of some E2F-dependent genes are not directly specified by Rb binding, in contrast to what is proposed for senescence. 相似文献
12.
RBP1 recruits the mSIN3-histone deacetylase complex to the pocket of retinoblastoma tumor suppressor family proteins found in limited discrete regions of the nucleus at growth arrest 总被引:7,自引:0,他引:7
下载免费PDF全文
![点击此处可从《Molecular and cellular biology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Lai A Kennedy BK Barbie DA Bertos NR Yang XJ Theberge MC Tsai SC Seto E Zhang Y Kuzmichev A Lane WS Reinberg D Harlow E Branton PE 《Molecular and cellular biology》2001,21(8):2918-2932
13.
14.
15.
16.
17.
18.
19.