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ldpA encodes an iron-sulfur protein involved in light-dependent modulation of the circadian period in the cyanobacterium Synechococcus elongatus PCC 7942
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We generated random transposon insertion mutants to identify genes involved in light input pathways to the circadian clock of the cyanobacterium Synechococcus elongatus PCC 7942. Two mutants, AMC408-M1 and AMC408-M2, were isolated that responded to a 5-h dark pulse differently from the wild-type strain. The two mutants carried independent transposon insertions in an open reading frame here named ldpA (for light-dependent period). Although the mutants were isolated by a phase shift screening protocol, the actual defect is a conditional alteration in the circadian period. The mutants retain the wild-type ability to phase shift the circadian gene expression (bioluminescent reporter) rhythm if the timing of administration of the dark pulse is corrected for a 1-h shortening of the circadian period in the mutant. Further analysis indicated that the conditional short-period mutant phenotype results from insensitivity to light gradients that normally modulate the circadian period in S. elongatus, lengthening the period at low light intensities. The ldpA gene encodes a polypeptide that predicts a 7Fe-8S cluster-binding motif expected to be involved in redox reactions. We suggest that the LdpA protein modulates the circadian clock as an indirect function of light intensity by sensing changes in cellular physiology. 相似文献
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The circadian clock-related gene pex regulates a negative cis element in the kaiA promoter region 总被引:1,自引:0,他引:1
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Kutsuna S Kondo T Ikegami H Uzumaki T Katayama M Ishiura M 《Journal of bacteriology》2007,189(21):7690-7696
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Estrogen receptor binding to DNA is not required for its activity through the nonclassical AP1 pathway 总被引:11,自引:0,他引:11
Jakacka M Ito M Weiss J Chien PY Gehm BD Jameson JL 《The Journal of biological chemistry》2001,276(17):13615-13621
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A novel chromatin-forming histone H1 homologue is encoded by a dispensable and growth-regulated gene in Bordetella pertussis 总被引:5,自引:1,他引:4
Vincenzo Scarlato Beatrice Aricó Sophie Goyard Stefano Ricci Riccardo Manetti Anna Prugnola Roberto Manetti Patrizia Polverino-De-Laureto Agnes Ullmann Rino Rappuoli 《Molecular microbiology》1995,15(5):871-881
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Improved gfp and inaZ broad-host-range promoter-probe vectors 总被引:1,自引:0,他引:1
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