The impact of genomics and related technologies on the search for new antibiotics

1. Summary,  7
2. Unmet medical need,  7
3. Addressing the real problems in antimicrobial drug  discovery,  7
4. Genomics and target selection,  8
5. Target to candidate drug,  10
6. Conclusions,  11
7. References,  11     

Reviews of Publications

book reviewed in this article:
Macroevolution. Pattern and Process , by S. M. Stanley.
A World List of Mammadian Species , by G. B. Corbet & J. E. Hill.
Indole and Biogenetically Related Alkaloids , edited by J. D. Phillipson & M. H. Zenk.
Comparative Ecology , by Y. Itô (edited and translated by J. Kikkawa).
The I.B.P. Survey of Conservation Sites: an Experimental Study , edited by A. R.
Man, the Promising Primate , by Peter J. Wilson.
The Pleistocene Mammals of North America , by Bjorn Kurten & Elaine Anderson.
British Gardeners , by Miles Hadfield, Robert Harling & Leonie Highton.
The Functioning of Freshwater Ecosystms , by E. D. LeCren & R. H. Lowe-McConnell.
I Fiori della Alpi by F. Rasetti.
The Oligocene Rodents of North America , by Albert E. Wood.
The Fossil Hunters in Search of Ancient Plants , by Henry N. Andrews.
Anatomy of the Dicotyledons, Vol. I , by C. R. Metcalfe & L. Chalk.     

Buchbesprechungen / Book Reviews

Book reviewed in this articles:
Sinclair, J. B. (Herausgeber) , Compendium of Soybean Diseases, 2nd edition.
Bach, W., J. Pankrath, S. H. Schneider (Herausgeber), Food-Climate Inter-actions.
Palti, J. , Cultural Practices and Infectious Crop Diseases.
Finck, A. , Fertilizers and Fertilization.
Turner, P. D. , Oil palm diseases and disorders.
Watkins, G. M. (ed.) , Compendium of cotton diseases.
Webster, H. S., Jr. , Plant Protection.
Robinson, D. G., and H. Quader (Ed.) , Cell Walls '81.
Progress in Botany (Fortschritte der Botanik) . Morphology — Physiology — Genetics — Taxonomy — Geobotany.
Maggenti, A. , General Nematology.
Chapeville, F., and A. L. Haenni (Ed.) , Chemical Recognition in Biology.
Rhodes-Roberts, M., und F. A. Skinner , Bacteria and Plants.
Michel, H,-G., und H. Umgelter , Pflanzenschutz im Garten.     

Book Reviews

Book Reviewed in this article:
DFG-ökotoxikologie von Pflanzenschutzmitteln-Mitteilungen I, 1994
Bennett, W. F. (ed) .
Arit, K. Enzian, S. and Pallut, B.
Ettl, H., G. Gärtner .
Blume, H.-P., Felix-Henningsen, P., Fischer, W. R., Frede, H.- G., Horn, R., Stahr, K.
Mielke, H.
Goodman, R.N., Novacky, A.J.
Karg, W., Freier, B.
Müller, R. et al .
Landsmann, J., Casper, R.
Shigo, A. L.
P etrini , O. and G. B. O uelletre (eds), Host Wall Alterations by Parasitic Fungi .     

Book Notes

Science in Alaska: Selected Papers of the Alaskan Science Conference of the National Academy of Sciences, National Research Council. Edited by Henry B. Collins.
The Indians of California in 1852. John Walton Caughey
Tupari; Unter Indios im Urwald Brasiliens. Franz Caspar.
Bloodstoppers and Bearwalkers. Richard M. Dorson.
La Familia Rural Haitiana. Remy Bastien.
Beilräge zur Völkerkunde Nordamerikas. Robert H. Lowie.
A Arte dos Indios Kadiuéu. Darcy Ribeiro.
Earliest Evidence of Banana Culture. Philip K. Reynolds.
Ancient South-east Asian Warfare. H. G. Quaritch Wales.
History of the Luapula. Ian Cunnison.
Marriage in a Changing Society. J. A. Barnes.
Recueil de Textes Falachas. A. Z. Aešcolv.
Time's Arrow and Evolution. Harold F. Blum.
The Idea of Conflict. Kurt Singer.
An Autobiographical Study. Sigmund Freud. Authorized Translation by James Strachey.
'Twixt the Cup and the Lip. Margaret Cussler and Mary L. De Give.     

REVIEWS

Review in this article:
Protoplasmatologia—Handbuch der Protoplasmaforschung . Band II, CI. The Viscosity of Protoplasm. By L. V. H eilbrunn .
Trace Element Problems in Nature . A Symposium in the Botany Department, University of Cape Town. Edited by D r . K. H. S chütte .
Cell, Organism and Milieu. (Seventeenth Growth Symposium). Edited by D orothea R udnick .
Subcellular Particles . Edited by T. H ayashi .
Plant Growth Substances . By L. J. A udus .
Uredineana. Receuil d': études systematiques et biologiques sur les Urédinées du Globe . Tome 5. By A. L. G uyot .
A Textbook of General Physiology . By H. D avson .
Protoplasmatologia . Vol. Ill AI. Le Chondriome de la Cellule Végétale: Morphologie du Chondriome; by P. D angeard .
Analytical Cytology . Edited by R obert C. M ellors .
Blakeslee: The Genus Datura . By A. G. A very , S. S atina and J. R ietsema .
The Royal Botanic Gardens, Kew, Past and Present . By W. B. T urrill .
Drawings of British Plants . Part XIII. Umbelliferae (2), Araliaceae, Cornaceae. By S tella R oss -C raig .
Physiology of Fungi. By V incent W. C ochrane .
Illustrated Moss Flora of Fennoscandia . Vol. II. Musci. Fasc. III. By E lsa N yholm .
An Outline of General Plant Geography . By W. S zafer .
Protoplasmatologia. Handbuch der Protoplasmaforschung . Ed. L. V. Heilbrunn and F. Weber. Vol. VIII; 9a. Polaritút und Inäquale Teilung des pflanzlichen Protoplasten . By Erwin Bünning, Tübingen.     

Book Reviews

Book reviews in this article:
Wetzel, Th. Integrierter Pflanzenschutz und Agroökosysteme.
The Indian Experience
Nagarajan, S. and K. Muralidharan Dynamics of Plant Diseases.
70. Geburtstages von Herrn Prof. Dr. J. Kranz Biochemie des Bodens.
McIntosh R. A., C. R. Welling, and R. F. Park . Wheat rusts—an Alias of Resistance Genes.
Haider, K. Biochemie des Bodens.
Kimber, D., McGregor, D. I., (eds) Brassica Oilseeds: Production and Utilization.
Oropeza, C, F. W. Howard, and G. R. Ashlninier (Eds); Lethal Yellowing: Research and Practical Aspects.
Kreuzer, J Kreuzers Gartenpflanzenlexikon 'Kurz und bũndig'.
Spatz, G. , Freiflächenpflege.
W. Eschiich , Rezension: Funktionelle Pflanzenanatomie .
Iecraemer, W. The family Trichodoridae: Stubby Root and Virus Vector Nematodes.     

REVIEWS

Book reviewed in this article:
Botanical Histochemistry: Principles and Practice . By W illiam A. J ensen .
The Biology of Cilia and Flagella . By M. A. S leigh .
Dünnschicht-Chromatographie . Edited by E gon S tahl .
Plant Embryology. A Symposium .
The Morphology of Pteridophytes . By K. R. S porne .
Introductory Mycology . By C. J. A lexopoulos .
Residue Reviews , Vol. 1. Edited by F. A. G unther .
Energy Exchange in the Biosphere . By D avid M. G ates .
Pathology of Trees and Shrubs with Special Reference to Britain . By T. R. P eace .
Modern Methods of Plant Analysis . Vol. V. Edited by H. F. L inskens and M. V. T racey .
The Growth of Plants . By G. E. F ogg .
An Introduction to Plant Physiology . By W. O. J ames .
Die Physiologische Uhr. Zeitmessung in Organismen mit ungefähr Tagesperiodischen Schwingungen . By E. B ünning .     

Reviews of Publications

Book reviewed in this article:
Flowers of the Himalaya , by Oleg Polunin and Adam Stainton.
A Guide to the Vegetation of Britain and Europe , by Oleg Polunin and Martin Walters.
The Experimental Biology of Bryophytes, edited by A. F. Dyer & J. G. Duckett.
A Birdwatcher's Miscellany, edited by Rob Hume.
The Moths and Butterjlies of Great Britain and Ireland, Volume 10, Noctuidae (Part II) and Agaristidae, edited by J. Heath.
Atlas of Butterjlies in Britain and Ireland, by J. Heath, E. Pollard & J. A. Thomas.
Colour Identification Guide to Butterjlies of the British Isles, revised edition by T. G. Howarth.
The World of Butterjlies, An Illustrated Encyclopaedia, by V. Sbordoni & S.Forestiero.
Colour Identijcation Guide to Moths of the British Isles, by Bernard Skinner.
The Biology of Buttegies, edited by R. I. Vane-Wright & P. R. Ackery.
Australian Grasses, by Nancy T. Burbidge, revised by Surrey W. L. Jacobs.
Collins Guide to Grasses, Sedges, Rushes and Ferns, by R. Fitter & A. Fitter. Collins.
Grasses of the Soviet Union, by N. N. Tsvelev, edited by A. A. Fedorov.
The European Garden Flora, Volume 2, Monocotyledons (Part ZZ), edited by S. M Walters et al.
Grasses, 3rd edition, by C. E. Hubbard, revised by J. C. E. Hubbard.     

Reviews

Book Reviewed in this article:
Phytochrome. Ed. by K. M itrakos and W. S hropshire J nr .
Progress in Phytochemistry. Vol. 3. Ed. by L. R einhold and Y. L iwscihtz .
Phytochemical Ecology. Ed. by J. B. H arborne .
Microbiology of the Atmosphere. By P. H. G regory .
Analysis of Leaf Development. By R. M aksymowych .
The Amphi-Atlantic Plants and their Phytogeographical Connections. By E ric H ultÉan .
Drawings of British Plants. Part XXIX. Iridaceae, Amaryllidaceae, Dioascoreaceae and Liliaceae. By Stella Ross Craig.
Les Cypéracées Forestières de Côte d'lvoire (Mémoire O.R.S.T.O.M. No. 58). By G. Lorougnon.     

Buchbesprechungen/Book Reviews

Book reviews in this article:
Bromfield, Kenneth R. , Soybean Rust.
„Diagnosemethoden” — Verantwortlich bearbeitet von T heo W etzel
Helgeson, J. P., and B. J. Deverall (Eds.) , Use of Tissue Culture and Protoplasts in Plant Pathology.
Moser, E. , Verfahrenstechnik in Intensivkulturen
Creasy, L. L., and H. Hrazdina , Cellular and Subcellular Localization in Plant Metabolism.
Gonick, L., und M. Wheelis , Genetik in Cartoons.
Johri, B. M. (Ed.) , Experimental embryology of vascular plants.
Böhmer, B. Ratgeber für Pflanzenschutz und Unkrautbekämpfung im Zierpflanzenbau.
Heitefuß, R., K. Konig, A. Obst und M. Reschke , Pflanzenkrankheiten und Schädlinge im Ackerbau.
Thurston, H. D. , Tropical Plant Diseases.     

Reviews

Book Reviewed in this article:
Botanical Microtechnique and Cytochemistry. By G. P. Berlyn and J. P. Miksche.
Annual Review of Plant Physiology. Ed. by W. R. Briggs.
Mechanical Design in Organisms. By S. A. Wainwright, W. D. Biggs, J. D. Currey & J. M. Gosline.
Uptake of Ions by Plant Roots. By D. J. F. Bowling.
Phytochrome and Photomorphogenesis. By Harry Smith.
Water and Plants. By Hans Meidner and D. W. Sheriff.
Physiological Aspects of Dryland Farming. Edited by U. S. Gupta.
Pollen: Biology, Biochemistry, Management. By R. G. Stanley and H. F. Linskens.
The Evolutionary Significance of the Exine. Ed. by I. K. Ferguson and J. Muller.
Cell Division in Higher Plants. Ed. by M. M. Yeoman.
Intercellular Communication in Plants: Studies on Plasmodesmata Ed. by B. E. S. Gunning & A. W. Robards.
Methods in Plant Ecology. Ed. by S. B. Chapman
Ökologie DER Pflazen By Walter Larcher.
Progress in Botany. Vol. 37. Ed. by H. Ellenberg, K. Esser, H. Merxmüller, E. Schnepf & H. Ziegler.
British Botanical and Horticultural Literature before 1800. By Blanche Henrey.     

Reviews of publications

Book reviewed in this article:
Marine fish larvae-morphology, ecology and relation to fisheries , edited by Reuben Lasker.
Environmental Physiology of Plants , by A. H. Fitter & R. K. M. Hay.
Plant Taxonomy and Biosystematics , by Clive A.
Dinosaurs , by L. B. Halstead &Jenny Halstead.
Large White Butterfly. The biology, biochemistry and physiolosy of Pieris brassicae ( Linnaeaus ), by John Feltwell.
Omnivorous primates: Gathering and hunting in human evolution , edited by Robert S. O. Harding and Geza Teleki.
Handbook of Zoo Medicine , by Heinz George Klös & Ernst Lang.
Cetacean behaviour: Mechanisms and functions , edited by L. M. Herman Wiley     

REVIEWS

Book reviewed in this article:
Plant Disease Handbook. By C ynthia W estcott .
'Untersuchungen über die Zusammenhänge zwischen Exposition, Relief, Mikroklima und Vegetation in der Fallätsche bei Zurich.' By J erzy F abijanowski .
Beitrdge zur geobotanischen Landesaufnahme der Schweiz
Studies in Late Qitaternary Deposits and Flora-History of Ireland . By K nud J essen .
Praktikum der Pflanzenanatomie . By R ichard B iebl and H ermann G erm .
Carotenoids. By P. K arrer and E. J ucker . Translated by E. C. B raude .
Elemente der Botanik. By E. H eitz .
The Actinomycetes. By S elman A. W aksman .
Wild Flowers of the Cape Peninsula. By M ary M aytham K idd .
Iodine and Plant Life. Bibliography, 1813–1949.
Pflanzen-Wuchsstoffe in ihrer Bedeutung für Gartenbau, Land- und Forstwirtschaft. By F. L aibach and O. F ischnich .
Plant Viruses and Virus Diseases. By F. C. B awden .     

REVIEWS

Books reviewed in this article:
Plant Anatomy: Experiment and Interpretation , Part II, Organs. By E lizabeth G. C utter .
Genetics. By D. J. C ove .
The Structure and Life of Bryophytes. By E. V. W atson .
Underwater Science. Ed. by J. D. W oods and J. J. L ythgoe .
8ème Symposium Européen sur les Maladies à Virus des Arbres Fruitiers.
Evolution and Plants of the Past. By H. P. B anks .
Project Aqua. A Source Book of Inland Waters Proposed for Conservation. IBP Handbook No. 21. By H. L uther and J. R zóska .
Variation and Adaptation in Plant Species. By D. A. J ones and D. A. W ilkins .
Flora of Lesotho (Basutoland). By A my J acot G uillarmod .
Introduction to Biogeography. By B rian S eddon .
Trees: Structure and Function. By M. H. Z immerman and C. L. B rown ;
Flora of New Zealand , Volume II. By L. B. M oore and E. E dgar .     

REVIEWS

Review in this article:
Outline of Palaeobotany. By W ładysław S zafer and M ikołaj K ostyniuk .
[ Zarys Palaeobotaniki. W ładysław S zafer i M ikołaj K ostyniuk .]
Annual Review of Plant Physiology , Vol. V. Edited by D. J. A rnon and L. M achlis .
Analytic Studies in Plant Respiration. By the late F. F. B lackman .
Cold Spring Harbor Symposia on Quantitative Biology. Vol. xviii. Viruses.
Plant Life in Malaya. By R. E. H olttum .
The Changing Flora of Britain. By J. E. L ousley .     

Reviews

Book Reviewed in this article:
Phloem Transport in Plants. By A. S. C rafts and C. H. C risp .
Introduction to the Fine Structure of Plant Cells. By M yron C. L edbetter and K eith R. P orter .
Symposia of the Society for Experimental Biology No. 25. Control Mechanisms of Growth and Differentiation. Ed. by D. D. D avies and M. B alls .
Plant Lipid Biochemistry. By C. H itchcock and B. W. N ichols .
Cell Respiration. By W. O. J ames .
Prediction and Measurement of Photosynthetic Productivity.
Fortschritte der Botanik , Vol. 32. Ed. by H. E llenberg , K. E sser , H. M erxmüller , P. S itte and H. Z iegler .
Stoffwechselphysiologie der Pflanzen. By G. R ichter .
Pflanzenphysiologie. By D. H ess .
Moleculare Grundlagen der Entwicklung. By H. M ohr and P. S itte .
The Diversity of Green Plants. By P eter B ell and C hristopher W oodcock .
Anatomy of the Monocotyledons. Ed. by C. R. M etcalfe . Vol. V. Cyperaceae. By C. R. M etcalfe .
Soil Micro-organisms. By T. R. G. G ray and S. T. W illiams .
Des Ovules aux Graines. By M. F avre -D uchartre .
Ecology of Leaf Surface Micro-organisms. Ed. by T. F. P reece and C. H. D ickinson .
Fungal Genetics. By J. R. S. F incham and P. R. D ay .
Étude du Mode de Reproduction: Apomixie Facultative du Point de Vue de la Génétique des Populations. (Study of Facultative Apomixis from the View-point of Population Genetics). By J. P erèns .
Drawings of British Plants ; Part XXVIII: Hydrocharitaceae, Orchidaceae. By S tella R oss -C raig .
Plants of Hong Kong. By S. L. T hrower .
An Atlas of Plant Structure , Vol. 1. By B rian B racegirdle and P atricia H. M iles .
Bioiléctricité, Quelques Problèmes. By S. M eylan .
Studying the Past by Pollen Analysis. By R. G. W est .
The Mysterious Origin of Flowering Plants. By K enneth R. S porne .     

Besprechungen

Book reviews in this article:
Fungicides . An advanced treatise.
Bibliographie der Pflanzensdiutzliteratur , bearbeitet von W. L aux und W. S ikker .
Miiller, E., und W. Loeffler , Mykologie.
Nultsdi, W., und A. Grahle , Mikroskopisch-Botanisches Praktikum für Anfänger.
Rapilly, F. , Les tediniques ide mycologie en pathologie végétale.     

REVIEWS

Book reviewed in this article:
Forest Flora of Northern Rhodesia . By F. W hite , assisted by A. A ngus .
Tools of Biological Research . Edited by H edley J. B. A tkins .
Eigenschaften und Wirkungen der Gibberelline . Symposium der Oberhessischen Gesell-schaft für Nature- und Heilkunde, Naturwissenschaftliche Abteilung zu Gieszen vom I bis 3 Dezember, 1960. Edited by R. K napp .
Regeneration . Edited by D orothea R udnick .
Marsilea . By K. M. G upta .
Diseases of Sorghum, Sudan Grass and Broom Corn. By S. A. J. T arr .
Proceedings of the IX International Botanical Congress. Vol. 3. Plenary Sessions; Nomenclature .
Mutations and Polyploidy in Plant Breeding . By A rne H agberg and E rik Å kerberg .
Nitrogen Metabolism in Plants . By H. S. M c K ee .