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Regulation of the bone-specific osteocalcin gene by p300 requires Runx2/Cbfa1 and the vitamin D3 receptor but not p300 intrinsic histone acetyltransferase activity
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Sierra J Villagra A Paredes R Cruzat F Gutierrez S Javed A Arriagada G Olate J Imschenetzky M Van Wijnen AJ Lian JB Stein GS Stein JL Montecino M 《Molecular and cellular biology》2003,23(9):3339-3351
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Role of Cbfa1 in osteoblast differentiation and function 总被引:13,自引:0,他引:13
Karsenty G 《Seminars in cell & developmental biology》2000,11(5):343-346
Among the multiple cell lineages whose differentiation is affected by a runt-related gene the osteoblast is a relative newcomer. Molecular biology, developmental biology and mouse and human genetic studies have demonstrated that Cbfa1 is a critical regulator of osteoblast differentiation in vertebrates. Cbfa1 is not only a differentiation factor but also a regulator of bone formation by differentiated osteoblasts beyond development. Thus, Cbfa1 controls osteogenesis at multiple stages. 相似文献
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p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene 总被引:5,自引:0,他引:5
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Cao W Daniel KW Robidoux J Puigserver P Medvedev AV Bai X Floering LM Spiegelman BM Collins S 《Molecular and cellular biology》2004,24(7):3057-3067
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runt homology domain transcription factors (Runx, Cbfa, and AML) mediate repression of the bone sialoprotein promoter: evidence for promoter context-dependent activity of Cbfa proteins 总被引:6,自引:0,他引:6
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Javed A Barnes GL Jasanya BO Stein JL Gerstenfeld L Lian JB Stein GS 《Molecular and cellular biology》2001,21(8):2891-2905
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