共查询到20条相似文献,搜索用时 31 毫秒
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Regulation of angiotensin II-induced phosphorylation of STAT3 in vascular smooth muscle cells. 总被引:6,自引:0,他引:6
H Liang V J Venema X Wang H Ju R C Venema M B Marrero 《The Journal of biological chemistry》1999,274(28):19846-19851
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Src kinases mediate STAT growth pathways in squamous cell carcinoma of the head and neck 总被引:9,自引:0,他引:9
Xi S Zhang Q Dyer KF Lerner EC Smithgall TE Gooding WE Kamens J Grandis JR 《The Journal of biological chemistry》2003,278(34):31574-31583
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Schreiner SJ Schiavone AP Smithgall TE 《The Journal of biological chemistry》2002,277(47):45680-45687
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The collagen repeat sequence is a determinant of the degree of herpesvirus saimiri STP transforming activity 下载免费PDF全文
Herpesvirus saimiri (HVS) is divided into three subgroups, A, B, and C, based on sequence divergence at the left end of genomic DNA in which the saimiri transforming protein (STP) resides. Subgroup A and C strains transform primary common marmoset lymphocytes to interleukin-2-independent growth, whereas subgroup B strains do not. To investigate the nononcogenic phenotype of the subgroup B viruses, STP genes from seven subgroup B virus isolates were cloned and sequenced. Consistent with the lack of oncogenic activity of HVS subgroup B viruses, STP-B was deficient for transforming activity in rodent fibroblast cells. Sequence comparison reveals that STP-B lacks the signal-transducing modules found in STP proteins of the other subgroups, collagen repeats and an authentic SH2 binding motif. Substitution mutations demonstrated that the lack of collagen repeats but not an SH2 binding motif contributed to the nontransforming phenotype of STP-B. Introduction of the collagen repeat sequence induced oligomerization of STP-B, resulting in activation of NF-kappaB activity and deregulation of cell growth control. These results demonstrate that the collagen repeat sequence is a determinant of the degree of HVS STP transforming activity. 相似文献
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Fox EM Bernaciak TM Wen J Weaver AM Shupnik MA Silva CM 《Molecular endocrinology (Baltimore, Md.)》2008,22(8):1781-1796
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Role of the Jak/STAT pathway in the regulation of interleukin-8 transcription by oxidized phospholipids in vitro and in atherosclerosis in vivo 总被引:1,自引:0,他引:1
Gharavi NM Alva JA Mouillesseaux KP Lai C Yeh M Yeung W Johnson J Szeto WL Hong L Fishbein M Wei L Pfeffer LM Berliner JA 《The Journal of biological chemistry》2007,282(43):31460-31468
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Multilevel dysregulation of STAT3 activation in anaplastic lymphoma kinase-positive T/null-cell lymphoma. 总被引:20,自引:0,他引:20
Qian Zhang Puthryaveett N Raghunath Liquan Xue Miroslaw Majewski David F Carpentieri Niels Odum Stephan Morris Tomasz Skorski Mariusz A Wasik 《Journal of immunology (Baltimore, Md. : 1950)》2002,168(1):466-474
Accumulating evidence indicates that expression of anaplastic lymphoma kinase (ALK), typically due to t(2;5) translocation, defines a distinct type of T/null-cell lymphoma (TCL). The resulting nucleophosmin (NPM) /ALK chimeric kinase is constitutively active and oncogenic. Downstream effector molecules triggered by NPM/ALK remain, however, largely unidentified. Here we report that NPM/ALK induces continuous activation of STAT3. STAT3 displayed tyrosine phosphorylation and DNA binding in all (four of four) ALK+ TCL cell lines tested. The activation of STAT3 was selective because none of the other known STATs was consistently tyrosine phosphorylated in these cell lines. In addition, malignant cells in tissue sections from all (10 of 10) ALK+ TCL patients expressed tyrosine-phosphorylated STAT3. Transfection of BaF3 cells with NPM/ALK resulted in tyrosine phosphorylation of STAT3. Furthermore, STAT3 was constitutively associated with NPM/ALK in the ALK+ TCL cell lines. Additional studies into the mechanisms of STAT3 activation revealed that the ALK+ TCL cells expressed a positive regulator of STAT3 activation, protein phosphatase 2A (PP2A), which was constitutively associated with STAT3. Treatment with the PP2A inhibitor calyculin A abrogated tyrosine phosphorylation of STAT3. Finally, ALK+ T cells failed to express a negative regulator of activated STAT3, protein inhibitor of activated STAT3. These data indicate that NPM/ALK activates STAT3 and that PP2A and lack of protein inhibitor of activated STAT3 may be important in maintaining STAT3 in the activated state in the ALK+ TCL cells. These results also suggest that activated STAT3, which is known to display oncogenic properties, as well as its regulatory molecules may represent attractive targets for novel therapies in ALK+ TCL. 相似文献