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1.
Effect of selenium on the immunocompetence of patients with head and neck cancer and on adoptive immunotherapy of early and established lesions 总被引:2,自引:0,他引:2
Supplementation with 200 microg/day of sodium selenite during therapy for squamous cell carcinoma (SQCC) of the head and neck, e.g., surgery, radiation, or surgery and radiation, resulted in a significantly enhanced cell-mediated immune responsiveness. The enhanced responsiveness was evident during therapy and following conclusion of therapy. In contrast, patients in the placebo arm of the study showed a decline in immune responsiveness during therapy. The results from studies on mice inoculated with SQCC cells expressing the receptor for interleukin-2 (IL-2) and supplemented with Se (2.00 ppm) indicated that Se significantly retards the clinical appearance of tumors; peritumoral injections of 2,000 IU of IL-2 resulted in 50% reduction in the size of established tumors and 72% of early tumors. The combined data suggested that local immunotherapy with IL-2 in hosts supplemented with Se may represent an effective modality of treatment for the prevention of recurrences at the site of conventionally treated primary tumors. 相似文献
2.
Alfthan G Xu GL Tan WH Aro A Wu J Yang YX Liang WS Xue WL Kong LH 《Biological trace element research》2000,73(2):113-125
Keshan disease is a cardiomyopathy restricted to the endemic areas of China and seen in residents having an extremely low
selenium (Se) status. Prophylactic administration of sodium selenite has been shown to decrease significantly the incidence
of acute and subacute cases. The aim of the study was to assess the relative bioavailability of selenite versus organic Se-yeast
in a Se-deficient area in China with a randomized double-blind double-dummy design.
Healthy children (n=30) between 14 and 16 yr of age were randomized into three equal groups receiving either 200 μg/d selenite Se or 200 μg/d
Se-yeast or placebo for 12 wk. Blood was drawn at baseline, 4, 8, and 12 wk and 4 wk postsupplementation. The plasma Se concentration
(mean ± SD) was 0.16±0.03 μmol/L at baseline. Selenite and Se-yeast supplementation increased plasma Se to plateau values,
1.0±0.2 and 1.3±0.2 μmol/L, respectively. In red cells, Se-yeast increased the selenium level sixfold and selenite threefold
compared to placebo. The relative bioavailability of Se-yeast versus selenite measured as glutathione peroxidase (GSHPx) activity
was similar in plasma, red blood cells, and platelets. GSHPx activity reached maximal levels in plasma and platelets of 300%
and 200%, respectively, after 8 wk compared to the placebo group, but continued to increase in red cells for 16 wk.
Our study showed that although both forms of Se were equally effective in raising GSHPx activity, Se-yeast provided a longer
lasting body pool of Se. Se-yeast may be a better alternative to selenite in the prophylaxis of Keshan disease with respect
to building up of body stores. 相似文献
3.
Zuo-Wen Zhang Shinichiro Shimbo Jiang-Bin Qu Takao Watanabe Haruo Nakatsuka Naoko Matsuda-Inoguchi Kae Higashikawa Masayuki Ikeda 《Biological trace element research》2001,80(2):125-138
To assess the levels of daily dietary intake of selenium (Se) among the general Chinese population, a series of field surveys
were conducted in the 1990s. Samples of 24-h duplicates of foods were collected from 500 participants (300 in 6 cites and
200 from 4 villages). Se levels were determined by microwave digestion followed by inductively coupled plasma-mass spectrometry
(ICP-MS), and the measurements were compared with FCT (Food Composition Tables)-based estimates. The average daily intake
of Se was 69.2 μg/d (79.9 and 53.1 μg/d in urban and rural areas, respectively) by instrumental determination and 35.1 μg/d
(36.7 and 32.7 μg/d) by FCT-based estimation. As the distribution of Se should be uneven within China, the FCT-based estimation
is of a limited value and the ICP-MS determination of Se is more accurate and reliable when evaluating the nutritional status
of local people. Taking ICP-MS-based values, Se intakes were lower in rural areas than in urban areas, and the intakes of
about half of the people in rural areas were less than the Recommended Daily Allowance (RDA) in China of 50 μg/d. The low
intake might be resulted from difference in the types of food consumed. Thus, the dietary intake of Se basically meets the
recommended RDA in most of urban areas, but insufficiency may be still a nutritional and public health problem in some rural
areas. 相似文献
4.
High-selenium yeast supplementation in free-living North American men: no effect on thyroid hormone metabolism or body composition. 总被引:1,自引:1,他引:0
Wayne Chris Hawkes Nancy L Keim B Diane Richter Mary B Gustafson Barbara Gale Bruce E Mackey Ellen L Bonnel 《Journal of trace elements in medicine and biology》2008,22(2):131-142
In a prior study, we observed decreased serum 3,3',5-triiodothyronine (T(3)), increased serum thyrotropin and increased body weight in five men fed 297 microg/d of selenium (Se) in foods naturally high in Se while confined in a metabolic research unit. In an attempt to replicate and confirm those observations, we conducted a randomized study of high-Se yeast supplements (300 microg/d) or placebo yeast administered to 42 healthy free-living men for 48 weeks. Serum thyroxine, T(3) and thyrotropin did not change in supplemented or control subjects. Body weight increased in both groups during the 48-week treatment period and remained elevated for the 48-week follow-up period. Body fat increased by 1.2 kg in both groups. Energy intake and voluntary activity levels were not different between the groups and remained unchanged during the treatment period. Dietary intakes of Se, macronutrients and micronutrients were not different between groups and remained unchanged during the treatment period. These results suggest that our previous observation of a hypothyroidal response to high-Se foods was confounded by some aspect of the particular foods used, or were merely chance observations. Because of the high dose and long administration period, the present study suggests that the effects of Se supplements on thyroid hormone metabolism and energy metabolism in healthy North American men with adequate Se status do not represent a significant risk for unhealthy weight gain. 相似文献
5.
Selenium in the treatment of autoimmune thyroiditis 总被引:2,自引:0,他引:2
We recently conducted a prospective, placebo-controlled clinical study, where we could demonstrate, that a substitution of 200 microg sodium selenite for three months in patients with autoimmune thyroiditis reduced thyroid peroxidase antibody (TPO-Ab) concentrations significantly. Forty-seven patients from the initially 70 patients agreed to participate in a follow-up cross-over study for further six months. One group (n = 13), which initially received selenium continued to take 200 microg sodium selenite (Se-Se), one group stopped taking selenium (Se-0) ( n = 9), another group which received placebo started to take 200 microg selenium (n = 14) (Plac-Se) and the last group was without selenium substitution (Plac-0) (n = 11). TPO-Ab concentrations were measured at beginning and the end of the study. In the Se-Se group, the TPO-Ab concentrations further significantly p = 0.004) decreased from 625 +/- 470 U/ml to 354 +/- 321 U/ml, in the Se-0 group the TPO-Ab concentrations increased significantly p = 0.017) from 450 +/- 335 to 708 +/- 313 U/ml. In the placebo group, the TPO-Ab concentrations in those patients who were followed without selenium substitution were unchanged (1351 +/- 940 vs. 1724 +/- 1112 U/ml, p = 0.555). In contrast, the patients who received 200 microg sodium selenite after placebo, the TPO-Ab concentrations decreased significantly (p = 0.029) from 1182 +/- 723 to 643 +/- 477 U/ml. 相似文献
6.
Janghorbani M Mooers CS Ting BT Smith M Lynch NE 《The Journal of nutritional biochemistry》1990,1(2):103-106
The time course of changes in whole body endogenous selenium (Se(end)) was investigated during a short-term (7-day) selenium restriction study in the adult rat. The method of continuous feeding with a stable isotope of selenium was used to permit normal intake of selenium while distinguishing between the dietary and endogenous components of body selenium. Additionally, the effect of short-term selenium restriction on the time course of the selenite-exchangeable metabolic pool (Se-EMP) was investigated. Two groups of adult male rats were intubated with the in vivo stable isotope (74)SeO(3)(2-), then fed a Torula yeast diet (selenium <0.02 microg/g) and either deionized water (-Se group) or deionized water containing selenium as (76)SeO(3)(2-) (0.1 microg selenium/ml) (+Se group). Three animals from each group were killed at 24-hour intervals. Whole body Se(end) and the estimated size of Se-EMP (W(Se-EMP)) were determined using hydride generation-inductively coupled plasma mass spectrometry for isotopic measurements. Whole body Se(end) decreased linearly in the +Se group (Se degrees (end): 54.4 microg; Se(end) at 3 days: 49.3 +/- 2.1; Se(end) at 7 days: 45.2 +/- 2.2). The decrease was exponential for the -Se group (Se degrees (end): 54.4 microg; Se(end) at 3 days: 42.9 +/- 0.3; Se(end) at 7 days: 42.2 +/- 0.7). The value of W(Se-EMP,pl) (microg) was 19.8 +/- 0.6 at 1 day and 19.7 +/- 1.0 at 7 days for the +Se group. The corresponding values for the -Se group were 15.7 +/- 1.5 and 18.8 +/- 0.4. All respective values of W(Se-EMP,pl) for the -Se group were significantly smaller than for the +Se group (P < 0.05), with the exception of values at days 6 and 7. The value of W(Se-EMP,urine) (microg) was 2.1 +/- 0.2 at 1 day, increasing rapidly to 23.5 +/- 1.5 at 7 days for the +Se group. The corresponding values for the -Se group were 3.0 and 23.1. 相似文献
7.
Wayne Chris Hawkes Amie Hwang Zeynep Alkan 《Journal of trace elements in medicine and biology》2009,23(4):272-280
The trace element selenium (Se) is essential for immune system development and function in animals. However, the exact functions of Se in the human immune system and the achievable health benefits from Se supplementation remain unclear. To test whether an increased intake of dietary Se affects immune function, we conducted a randomized, controlled trial of Se supplementation in healthy free-living men. Forty-two men were administered 300 μg of Se a day as high-Se Baker's yeast, or low-Se yeast for 48 weeks. Serum immunoglobulins, differential complete blood counts and lymphocyte sub-populations were measured every 6 weeks. Tests of delayed-type hypersensitivity (DTH) skin responses to mumps, candida, trychophyton, tuberculin-purified protein, and tetanus were performed at baseline and at the end of 48 weeks of treatment. Supplementation increased blood Se concentration by 50%. Surprisingly, consumption of the low-Se yeast induced anergy in DTH skin responses and increased counts of natural killer (NK) cells and T lymphocytes expressing both subunits of the high affinity interleukin-2 receptor (IL2R). DTH skin responses and IL2R+ cells did not change in the high-Se group, suggesting Se supplementation blocked induction of DTH anergy. There were no differences between groups in quality of life indicators, number of days sick, other leukocyte phenotypes, serum immunoglobulins, or complement factors. These results suggest that Se plays a role in immunotolerization, a cell-mediated process involved in many aspects of immune function. 相似文献
8.
Samples of healthy tissue were taken from each of six prostatectomy specimens (55–72 yr), digested with acids, and analyzed
for selenium by atomic fluorescence spectroscopy. The concentrations for five specimens were 1.32±0.09 μg Se/g dry wt (range
1.24–1.42) and 0.213±0.012 μg Se/g wet wt (range 0.200–0.229). The other specimen, from a 58-yr-old man who was the only one
within this study to take a 200-μg Se/d dietary supplement, contained 2.72 μg Se/g dry wt and 0.421 μg Se/g wet wt. 相似文献
9.
Eleven men were fed foods naturally high or low in selenium for 120 d. Selenium intake was stabilized at 47 μg/d for 21 d,
then changed to either 13 or 297 μg/d for 99 d, leading to significantly different blood selenium and glutathione peroxidase
concentrations. Serum immunoglobulins, complement components, and primary antibody responses to influenza vaccine were unchanged.
Antibody titers against diphtheria vaccine were 2.5-fold greater after reinoculation in the high selenium group. White blood
cell counts decreased in the high-selenium group and increased in the low-selenium group, resulting primarily from changes
in granulocytes. Apparent increases in cytotoxic T-lymphocytes and activated T-cells in the high-selenium group only approached
statistical significance. Lymphocyte counts increased on d 45 in the high-selenium group. In vitro proliferation of peripheral
lymphocytes in autologous serum in response to pokeweed mitogen was stimulated in the high-selenium group by d 45 and remained
elevated throughout the study, whereas proliferation in the low selenium group did not increase until d 100. This study indicates
that the immune-enhancing properties of selenium in humans are the result, at least in part, of improved activation and proliferation
of B-lymphocytes and perhaps enhanced T-cell function. 相似文献
10.
Djujić IS Jozanov-Stankov ON Milovac M Janković V Djermanović V 《Biological trace element research》2000,77(3):273-285
Bioavailability and possible benefits of wheat intake naturally enriched with selenium and its products was tested. Wheat
obtained by application of an original combination and procedure for foliar supplementation of plants with Se was characterized
on the average by five times higher content of Se, the main form being l-(+)-selenomethionine (SeMet). Substitution of Se-deficient wheat by wheat naturally enriched with Se and its products contributed
to the increase of daily intake on the average by 18 μg (12–35 μg) in volunteers, which is more than 50% of the average daily
intake.
Six weeks after the beginning of its application, increased daily intake of Se brought about the increase of its concentration
in the plasma of the examined persons by 53%, in their erythrocytes by 37%, in their hair by 44%, and in their urine by 54%.
This result was comparable to the effect obtained in the course of an 8-wk daily intake of supplements with 100 μg Se in the
form of enriched bakery yeast.
Analysis of glutathione peroxidase (GSH-Px) activity in blood, thiobarbituric acid reactive substances (TBARS) in plasma,
lipid parameters (total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerides),
and glucose in serum of volunteers showed that the increased Se intake induced increased GSH-Px activity in blood and decreased
concentrations of TBARS, lipid parameters, and glucose in blood.
Using only one crop (wheat enriched with Se), the existing deficiency of Se in our population can be alleviated. In this way,
one-fourth of our population with lower Se intake than 21 μg/d will satisfy basal requirements, whereas one-half will become
moderately deficient in Se instead of distinctly deficient in Se. 相似文献
11.
Xi Peng Yun Cui Wei Cui Junliang Deng Hengmin Cui 《Biological trace element research》2009,131(1):33-42
Selenium is an essential trace element possessing immune-stimulatory properties. The purpose of this 42-day study was to investigate
the effects of excess dietary sodium selenite on immune function by determining morphological changes and apoptosis of bursa
of Fabricius. Three hundred 1-day-old Avian broilers were fed on a basic diet (0.2 ppm selenium) or the same diet amended
to contain 1, 5, 10, and 15 ppm selenium supplied as sodium selenite (n = 60/group). Relative weight of bursa was significantly decreased in the 1, 5, 10, and 15 ppm groups at 28 days of age, when
compared with that of 0.2 ppm group. Pathological lesions were progressed with the dietary Se level increased. The gross lesions
of bursa involved obvious atrophy with decreased volume and pale color. Histopathologically, decreased number of lymphocytes
and loosely packed lymphocytes appeared in the medulla and cortex in the follicles. Ultrastructurally, mitochondria injury
and increased apoptotic cells with condensed nuclei were observed. In comparison to that of control group, excess Se (5, 10,
and 15 ppm) intake increased the percentage of Annexin V positive cells, as measured by flow cytometry. Terminal deoxynucleotidyl
transferase 2′-deoxyuridine 5′-triphosphate nick end-labeling assay showed that there were increased frequencies of apoptotic
cells in 10 and 15 ppm selenium groups. These data suggest that Se supplementation with sodium selenite should be carefully
evaluated as excess selenium (more than 5 ppm) intake could cause profound immunologic inhibition. 相似文献
12.
《Archives of animal nutrition》2013,67(1):48-61
Dietary selenium (Se) can be supplemented from organic or inorganic sources and this may affect Se metabolism and functional outcome such as antioxidative status and immune functions in dairy cows. A feeding trial was performed with 16 Holstein-Friesian dairy cows fed with a total mixed ration (0.18 mg Se/kg dry matter (DM)) either without Se supplement (Control, n = 5), or with Se from sodium selenite (Group SeS, n = 5) or Se yeast (Group SeY, n = 6). In Groups SeS and SeY, the Se supplementation amounted to an additional intake of 4 mg Se and 6 mg Se/d during gestation and lactation, respectively. The effect of both Se sources was characterised by milk Se and antioxidant levels, and the phenotyping and functional assessment of phagocytic activity of milk immune cells. Se yeast has been found to increase (p ≤ 0.001) the milk Se and antioxidant levels markedly compared to the control group. The experimental treatment did not affect the immune parameters of the cows. Lymphocyte subpopulations and phagocytosis activity of neutrophilic granulocytes were affected neither by the Se intake nor by the two different dietary supplements. It can be concluded that sodium selenite and Se yeast differ considerably in their effects on antioxidant status in dairy cows. However, the basal dietary Se concentration of 0.18 mg/kg DM seemed to be high enough for the measured immune variables. 相似文献
13.
The aim of this study was to assess the bioavailability of selenium (Se) in Se-enriched yeast and the possible impact of age, sex and area of residence on the Se concentration in plasma in 179 transplant recipients, as Se clinical effects in the prevention of cutaneous epithelial lesions in organ transplant recipients has been reported elsewhere. Subjects were randomized to receive either 200 μg Se/day (group 1:91 patients) or placebo (group 2: 88 patients) for 3 years. Plasma Se levels were measured at the beginning of the study and after 4, 12, 24 and 36 months of Se or placebo supplementation. Initial plasma Se levels were 90.9±26.1 μg/L for placebo and 94.0±25.3 μg/L for Se-supplemented groups. At baseline, the Se level was not linked to sex and age but to area of residence, although the number of subjects in each area was insufficient to draw any conclusions. Plasma Se levels were statistically lower in cases of liver transplant compared to kidney and heart transplant (p=0.03). Over the 3-year period of supplementation, plasma Se in the supplemented subjects was significantly higher than in the placebo group (p<0.01) and there was an interaction (p<0.01) between supplementation and time for plasma Se. Supplementation with Se-enriched yeast significantly increased the Se concentration in plasma of the patients to a plateau: the mean plasma Se of the Se-supplemented patients increased to 164.7±35.8 μg/L at 4 months and then remained similar at 12 (176.1±48.3 μg/L), 24 (176.1±54.2 μg/L) and 36 (182.2±46.4 μg/L) months. 相似文献
14.
Selenium and immune cell functions. I. Effect on lymphocyte proliferation and production of interleukin 1 and interleukin 2 总被引:2,自引:0,他引:2
L Kiremidjian-Schumacher M Roy H I Wishe M W Cohen G Stotzky 《Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)》1990,193(2):136-142
The dietary intake of selenium (Se) has been shown to influence the development and expression of various biologic processes. This study examined the immunologic competence of lymphocytes from C57BL/6J mice maintained for 8 weeks on Se-deficient (0.02 ppm Se), normal (0.20 ppm Se, as sodium selenite), or Se-supplemented (2.00 ppm Se) Torula yeast-based diets. The ability of the cells to recognize alloantigens, to proliferate in response to stimuli, and to produce interleukin 2 (IL-2) was determined. Se deficiency significantly inhibited the ability of the lymphocytes to proliferate in response to allogeneic stimulation in the mixed lymphocyte reaction or to mitogen stimulation by phytohemagglutinin, whereas Se supplementation significantly enhanced both responses. In contrast, the amounts of IL-2 and interleukin 1 (IL-1) produced by lymphocytes and macrophages, respectively, removed from Se-deficient or Se-supplemented animals did not differ significantly from the amounts of IL-2 and IL-1 produced by cells removed from animals maintained on the control diet. These results suggest that the mechanism(s) responsible for the observed effects of Se on lymphocyte proliferation are independent of the levels of IL-2 or IL-1. 相似文献
15.
16.
Zachara BA Koterska D Manitius J Sadowski L Dziedziczko A Salak A Wasowicz W 《Biological trace element research》2004,97(1):15-30
Patients with chronic renal failure (CRF) usually have a lower than healthy level of selenium (Se) in whole blood and plasma.
Plasma glutathione peroxidase (GSH-Px) is synthesized mostly in the kidney. In CRF patients, activity of this enzyme is significantly
reduced and its reduction increases with the progress of the disease. The aim of the study was to evaluate the effect of Se
supplementation to CRF patients at various stages of the disease on Se concentration in blood components and on plasma GSH-Px
activity.
The study group comprised 53 CRF patients at various stages of the disease supplemented with Se (200 μg/d for 3 mo as Se-enriched
yeast, containing about 70% l-selenomethionine [SeMet]). The control group consisted of 20 healthy subjects. The Se concentration in blood components was
measured spectrofluorometrically with 2,3-diaminonaphthalene as a complexing reagent. GSH-Px activity in red cell hemolysates
and plasma was assayed by the coupled method with tert-butyl hydroperoxide as a substrate.
The Se concentration in whole blood and plasma of CRF patients is significantly lower as compared with healthy subjects, but
similar at all stages of the disease. In the patients’ plasma, total protein and albumin levels are also significantly lower
than in healthy subjects. Plasma GSH-Px activity in patients is extremely low, and contrary to Se concentration, it decreases
linearly with the increasing stage of the illness. Se-supplied patients show an increased Se concentration in all blood components
and at all disease stages, whereas plasma GSH-Px activity is enhanced only at the incipient stage of the disease. Se supply
has no effect on plasma GSH-Px activity in uremic patients at the end stage of the disease. Total plasma protein and albumin
levels did not change after Se supplementation. Our data seem to show that in patients with CRF lower total protein and albumin
levels in plasma may be the chief cause of the low blood and plasma Se concentrations. GSH-Px activity decreases along with
the kidney impairment. At the end stage of the disease, Se supplementation in the form of Se-enriched yeast has no effect
on the increase in plasma GSH-Px activity. 相似文献
17.
Paola Borella Annalisa Bargellini Cristina Incerti Medici 《Biological trace element research》1996,51(1):43-54
In this work, possible interference with functional activities of human lymphocytes after in vitro treatment with selenium was examined. Sodium selenite and selenomethionine compounds were tested in parallel, and their capability to inhibit or to increase the antibody production by lymphocytes was investigated. Furthermore, after incubation for 7 d, total cell-associated Se was measured by a fluorimetric method. The in vitro doses of Se employed in this study mainly reflect those measured in blood of individuals with different Se intake. Low doses of Se (0.5–2.0μM) added either as sodium selenite or selenomethionine did not alter the secretion of antibodies. When Se was added at higher levels, instead, an inhibitory effect was found using selenite, whereas a progressive increase in immunoglobulin production was observed after exposure to selenomethionine. In both cases, modifications were detected at 5 μM (395 μg Se/L), and were significant at 10 μM (789 μg Se/L). A different trend between the two chemical forms was also observed with regard to Se uptake by cells. Interestingly, both Se uptake and cell sensitivity were influenced by the density of the cells in culture. Our data suggest that the biological effects of Se in mammalian systems are strongly influenced by its chemical form, and caution should be exerted to avoid toxic effects of selenium. 相似文献
18.
BackgroundA low intake of selenium has been shown to increase the risk of cardiovascular mortality, and supplementation of selenium and coenzyme Q10 influences this. The mechanism behind is unclear although effects on inflammation, oxidative stress and microRNA expression have been reported.Fructosamine, a marker of long-term glycaemic control, is also a marker of increased risk of heart disease and death, even in non-diabetics.ObjectiveTo analyse the impact of selenium and coenzyme Q10 supplementation on the concentration of fructosamine. Also, the relation between pre-intervention serum selenium concentration and the effect on fructosamine of the intervention was studied.MethodsFructosamine plasma concentration was determined in 219 participants after six and 42 months of intervention with selenium yeast (200 μg/day) and coenzyme Q10 (200 mg/ day) (n = 118 of which 20 had diabetes at inclusion), or placebo (n = 101 of which 18 had diabetes at inclusion). Pre-intervention, the serum selenium levels were 67 μg/L (active treatment group: 66.6 μg/L; placebo group: 67.4 μg/L), corresponding to an estimated intake of 35 μg/day. Changes in concentrations of fructosamine following intervention were assessed by the use of T-tests, repeated measures of variance, and ANCOVA analyses.ResultsPost-intervention selenium concentrations were 210 μg/L in the active group and 72 μg/L in the placebo group. A lower concentration of fructosamine could be seen as a result of the intervention in the total population (P = 0.001) in both the males (P = 0.04) and in the females (P = 0.01) in the non-diabetic population (P = 0.002), and in both the younger (<76 years) (P = 0.01) and the older (≥76 years) participants (P = 0.03). No difference could be demonstrated in fructosamine concentration in the diabetic patients, but the total sample was small (n = 38). In subjects with a low pre-intervention level of serum selenium the intervention gave a more pronounced decrease in fructosamine compared with those with a higher baseline selenium level.ConclusionA significantly lower concentration of fructosamine was observed in the elderly community-living participants supplemented with selenium and coenzyme Q10 for 42 months compared to those on the placebo. As oxidative mechanisms are involved in the glycation of proteins, less glycoxidation could be a result of the supplementation of selenium and coenzyme Q10, which could have contributed to lower cardiac mortality and less inflammation, as has earlier been reported.This study was registered at Clinicaltrials.gov, and has the identifier NCT01443780. 相似文献
19.
Recently published biochemical data suggest the significant role of selenium compounds as the adjuvants combined with L: -thyroxine therapy, which can reduce antithyroid peroxidase antibodies' (TPOAb) levels in patients with Hashimoto disease. The study was undertaken to document in a more detailed way the changes in parameters expressing the thyroid and ovarian function brought about by selenium supplementation (50-100 microg/day) in a woman undergoing autoimmune thyroiditis (AIT) therapy. This prospective observational case study lasted for 14 months plus additional 5 months as a follow-up period. Parameters reflecting selenium status, thyroid metabolism, and sex hormones secretion were determined at the onset and end of the study period, as well as in some of its middle points. During the supplementation trial, serum selenium (Se) increased by 45% and plasma glutathione peroxidase (GPX3) by 21%. TPOAb decreased by 76%. All other parameters also fluctuated during the supplementation period, but all results were always within normal physiological ranges. After withdrawal of the supplementation, the sharp fall of Se and GPX3 promptly occurred, and this phenomenon was accompanied with a marked increase in TPOAb. This report stresses the importance of selenium supplementation in AIT treatment. However, the efficiency and durability of the effect of Se supplementation on the TPOAb titer remain an open question. The clarification of mechanism(s) underlying Se interaction with autoimmune processes should throw new light on this issue. 相似文献
20.
Yukiko Miyazaki Hiroshi Koyama Masami Nojiri Shosuke Suzuki 《Journal of trace elements in medicine and biology》2002,16(2):83-90
Several studies have suggested that dietary selenium deficiency may be associated with an increased risk of coronary heart disease (CHD). In the present study, 55 men and 71 women were selected from participants in a health examination in a rural coastal community in Japan. The mean dietary selenium intake calculated from the simple food frequency questionnaire (SFFQ) was 127.5 micrograms/day. Fish was the major source of dietary selenium and it contributed to 68.7% of the daily total. HDL cholesterol was higher in the middle selenium intake group and in the high selenium intake group than in the low selenium intake group in all subjects and for males, and a significant difference was found between the middle selenium intake group and the low selenium intake group. The atherogenic index was significantly higher in the low selenium intake group than in the middle selenium intake group and in the high selenium intake group in males. GPx activity, total cholesterol and triacylglycerols did not show any significant differences among the three different selenium intake groups. Dietary intake of non-fish Se had a positive correlation with HDL cholesterol, and an inverse correlation with the atherogenic index in all subjects and for females. On the other hand, dietary intake of fish-Se had no relationship with any serum lipids. Non-fish Se is an important factor in selenium status for the prevention of CHD. 相似文献