共查询到20条相似文献,搜索用时 15 毫秒
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A Nakao T Imamura S Souchelnytskyi M Kawabata A Ishisaki E Oeda K Tamaki J Hanai C H Heldin K Miyazono P ten Dijke 《The EMBO journal》1997,16(17):5353-5362
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Rodriguez C Huang LJ Son JK McKee A Xiao Z Lodish HF 《The Journal of biological chemistry》2001,276(32):30224-30230
Using the plasminogen activator inhibitor (PAI) promoter to drive the expression of a reporter gene (mouse CD2), we devised a system to clone negative regulators of the transforming growth factor-beta (TGF-beta) signaling pathway. We infected a TGF-beta-responsive cell line (MvLu1) with a retroviral cDNA library, selecting by fluorescence-activated cell sorter single cells displaying low PAI promoter activity in response to TGF-beta. Using this strategy we cloned the proto-oncogene brain factor-1 (BF-1). BF-1 represses the PAI promoter in part by associating with both unphosphorylated Smad3 (in the cytoplasm) and phosphorylated Smad3 (in the nucleus), thus preventing its binding to DNA. BF-1 also associates with Smad1, -2, and -4; the Smad MH2 domain binds to BF-1, and the C-terminal segment of BF-1 is uniquely and solely required for binding to Smads. Further, BF-1 represses another TGF-beta-induced promoter (p15), it up-regulates a TGF-beta-repressed promoter (Cyclin A), and it reverses the growth arrest caused by TGF-beta. Our results suggest that BF-1 is a general inhibitor of TGF-beta signaling and as such may play a key role during brain development. 相似文献
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TGF-beta and the Smad signal transduction pathway. 总被引:31,自引:0,他引:31
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E1A inhibits transforming growth factor-beta signaling through binding to Smad proteins. 总被引:2,自引:0,他引:2
A Nishihara J Hanai T Imamura K Miyazono M Kawabata 《The Journal of biological chemistry》1999,274(40):28716-28723
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Nuclear factor YY1 inhibits transforming growth factor beta- and bone morphogenetic protein-induced cell differentiation 总被引:1,自引:0,他引:1
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Kurisaki K Kurisaki A Valcourt U Terentiev AA Pardali K Ten Dijke P Heldin CH Ericsson J Moustakas A 《Molecular and cellular biology》2003,23(13):4494-4510
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Regulation of Smad7 promoter by direct association with Smad3 and Smad4 总被引:26,自引:0,他引:26