一年又一年

上了年纪的人都有相似的感觉,就是年纪越大,时间好像过得越快。小时候,过了元旦盼春节,过了春节盼五一、六一,过了六一盼国庆,过了国庆再盼元旦。时间总是那么漫长,盼望的假期似乎总是姗姗来迟。而如今,似乎一眨眼,一年就过去了。我给这个现象总结了一个理论,叫做相对     

螺蚌壳的启示——谈谈古生代无脊椎动物

古老生命的时代从六亿到两亿多年前,在地球史上叫做古生代。古生代就是“古老生命的时代”的意思。从化石发现来看,生命到这个时代才相当繁荣起来。当然,古生代的生物已经相当复杂而多样了,这说明生物界已经经历了一段漫长的发展道路。不过,在古生代以前的生物,大多是海生浮游生物,身体大多是柔软组织,不容易保存成为化石。到了古生代,大多数生物过海底底栖生活了,身体里坚韧组织多了,保存成为化石的也就多起来了。动物界,各个门类的动物都出现了。特别是无脊椎动物的各个门类,有了很大的发展。植物界,除了被子植物门以外,其他门类的植物也都出现了。     

中国动物学会无脊椎动物分类区系学术讨论会在杭州市召开

中国动物学会无脊椎动物分类区系学术讨论会,1979年10月22—28日在浙江省杭州市举行。出席代表来自20个省市56个单位共89人。会议期间,新老科学家欢聚一堂,发扬学术民主,认真进行了学术讨论和经验交流,检阅了科研成果,讨论了共同关心的科研问题,了解了国内外研究的动态,分析了和与世界先进水平的差距,增强了赶超先进水平的信心。达到了预期的目的。     

伊克昭盟项目区水土保持的生态效益

根据对伊克昭盟世行项目区的监测数据,分析了项目实施后水土保持的生态效益。结果表明,项目实施后,改善了土壤的理化性质,增加了土壤肥力;同时,提高了当地的林草植被覆盖度,改善了局地气候,促进了生物多样性的恢复和保护。     

陕西蓝田新生界现场会议于11月上旬在西安举行

地质部、有关的大专院校和中国科学院三方面的11个单位,在过去的工作基础上,今年又在蓝田地区进行了大量考察和研究工作,井由中国科学院古脊椎动物与古人类研究所负责筹备举行了这次现场会议。现场会议是和全国第四纪第二次学术会议联合举行的,在第四纪学术会议之后,举行了现场会议。现场会议从11月3日下午起到8日止,共举行了5天半。会议广泛地讨论了蓝田新生界的问题,交流了工作经验,肯定了成绩,指出了缺点。会议开得很好,收获很大,基本上完成了大会所规定的任务     

酷想大晒台

正九头怪蛇相柳凶神恶煞,但其独特的多头造型却让猴子十分心动。于是,它们请大圣孙悟空施展法术,"添加"了好几个脑袋。这下,猴子的生活可精彩了。孙悟空变出了10个头后,饭量也增加了10倍。很快,花果山就变成了一片荒地,许多猴子都饿死了。猪八戒看见后,决定劫富济贫,结果还没来得及行动就被10个头的孙悟空吃了。聊城薛宸轩(等等,不是说好的孙悟空帮猴子们变化吗?它是不是,耳背听错了?)     

生物化学教学与QQ交流平台(群)的姻缘

在生物化学教学过程中既要传授基本知识,又要注重学生综合能力的培养。文中针对当前生物化学教学中存在的主要问题,提出了利用QQ交流平台的优势和特点,在师生间搭建QQ交流平台辅助教学。实践证明,该平台扩展了有限的课堂教学,增强了师生互动交流,激发了学生的学习兴趣,提高了学生学习的积极性和主动性,培养了学生的科学精神和创新能力,提高了教学质量。     

越来越苍老的世界

中国全面推行计划生育政策,少生了3亿多人,节约了7万亿抚养费,也少了3亿可以负担养老的劳动力。由于老龄化加速,老年抚养比由1964年的6.4%上升为2002年的11.6%,离退休金平均实际递增18.9%。到2050年,中国的抚养比将可能达到70%。老龄化速度,法国用了115年,英国用了80年,美国用了60年,我国用了18年。     

远程教育培训给生物教学带来新的生机

远程教育培训给生物教学带来新的生机。夯实了专业知识,梳理了生物知识,使我认识到应该如何把握生物课堂教学,提高了课堂教学设计能力,凝聚了生物教师的力量,使老师们学到了很多知识和教学技能,解决了平时教学中的一些难题,提升了生物的教学水平。     

基于科研能力综合提升的《环境工程微生物学及实验》教学改革

《环境工程微生物学及实验》是环境相关专业中一门重要的必修专业基础课。针对该课程的特点,提出了一个为期较长的教学改革计划,借助科研资源将理论授课与实践以及研究性实(试)验相融合,系统训练学生的综合科研能力。通过这一教学改革,激发了学生的学习热情,提升了学生的专业技能,培养了学生的创新意识。多数参与的本科生获得了科研项目资助,部分学生获批了国家专利。总体上,这一教学改革取得了良好的教学效果,为科研型学生的培养提供了依据。     

人疱疹病毒8型KS330基因片段的检出与Kaposi肉瘤的关系

HHV-8 sequences were recently identified in 100% of the amplifiable samples from AIDS patients with Kaposi's sarcoma(KS)and in 15% of the non-KS tissue samples from AIDS patients, so there is a strong correlation of Kaposi's sarcoma with HHV-8. Serum and DNA samples from a clinically diagnosed Kaposi's sarcoma Chinese patient were tested. HHV-8 antibody was tested positive by IFA and HIV-I antibody was negative by Western blot. The KS330 PCR product was found both in peripheral blood mononuclear cells and in KS tumor cells from this Chinese patient. This supports the hypothesis that Kaposi's sarcoma results from infection of HHV-8.     

HIV-1进攻靶细胞的机制及相应环节抑制剂

HIV－1是导致获得性免疫缺陷综合症（AIDS）的流行最广、破坏力最强的病毒。HIV－1分两个步骤特异性地进攻CD4^ 细胞：一是利用表面糖蛋白gp120和靶细胞膜上的受体结合;二是通过跨膜糖蛋白gp41使病毒的包膜和靶细胞的质膜发生融合,经过上述步骤,病毒的核心蛋白和遗传物质得以进入人体,然其中进行复制,遇时,细胞膜的稳定性被破坏,细胞的内外环境失去平衡,最终导致细胞死亡。HIV－1进攻靶细胞的机制研究所取得的成就为研制安全有效的抗HIV／AIDS药物提供了新的思路和方向。     

FROM MEDICAL RATIONING TO RATIONALIZING THE USE OF HUMAN RESOURCES FOR AIDS CARE AND TREATMENT IN AFRICA: A CASE FOR TASK SHIFTING

With a global commitment to scaling up AIDS care and treatment in resource‐poor settings for some of the most HIV‐affected countries in Africa, availability of antiretroviral treatment is no longer the principal obstacle to expanding access to treatment. A shortage of trained healthcare personnel to initiate treatment and manage patients represents a more challenging barrier to offering life‐saving treatment to all patients in need. Physician‐centered treatment policies accentuate this challenge. Despite evidence that task shifting for nurse‐centered AIDS patient care is effective and can alleviate severe physician shortages that currently obstruct treatment scale‐up, political commitment and policy action to support task shifting models of care has been slow to absent. In this paper we review the evidence in support of task shifting for AIDS treatment in Africa and argue that continued policy inaction amounts to unwarranted healthcare rationing and as such is ethically untenable.     

Declining incidence of AIDS dementia complex after introduction of zidovudine treatment.

OBJECTIVE--To assess the incidence of the AIDS dementia complex and the presence of HIV I p24 antigen in cerebrospinal fluid in relation to zidovudine treatment. DESIGN--Retrospective study of a consecutive series of patients with AIDS from 1982 to 1988. SETTING--An academic centre for AIDS. PATIENTS--196 Patients with AIDS and neurological symptoms examined from 1982 to 1988. INTERVENTIONS--Zidovudine treatment, which was introduced to The Netherlands on 1 May 1987 for patients with severe symptoms of HIV infection (Centers for Disease Control groups IVA, B, C, and D). MAIN OUTCOME MEASURES--Diagnosis of AIDS dementia complex and presence of HIV I p24 antigen in cerebrospinal fluid. RESULTS--The AIDS dementia complex was diagnosed in 40 of the 196 (20%) patients with AIDS. Thirty eight of 107 patients with AIDS (36%) not taking zidovudine developed the AIDS dementia complex compared with two of the 89 (2%) taking the drug (p less than 0.00001). The incidence of the AIDS dementia complex increased to 53% in the first half of 1987, after the introduction of zidovudine in May 1987, decreasing to 10% in the second half of 1987 and to 3% in 1988. Dementia was diagnosed before definition of the AIDS dementia complex (1986) according to DSM-III criteria and there was good agreement between diagnosis before and after 1986. Sixteen of 61 samples of cerebrospinal fluid (26%) from patients with AIDS (10 with the AIDS dementia complex) not taking zidovudine were positive for HIV I p24 antigen, whereas none of 37 cerebrospinal fluid samples from patients with AIDS (two with the AIDS dementia complex) taking zidovudine were positive. CONCLUSIONS--The incidence of AIDS dementia complex in patients with AIDS declined after the introduction of systematic treatment with zidovudine; the AIDS dementia complex might be prevented by inhibiting viral replication in the central nervous system.     

United Nations system efforts to support the response to AIDS in China

In the last two years, we have seen a remarkable intensification in the response to AIDS in China. A number of organizations have joined and contributed to the efforts of the Chinese government in responding the AIDS epidemic in China. This article specifically describes the role of the United Nations in supporting and strengthening those responses.Achievements of the United Nations (UN) highlighted in the article include: strengthened leadership and political commitment to respond to AIDS; improved HIV/AIDS surveillance and information; expanded prevention efforts; improved treatment, care and support to people living with HIV and increased resources for AIDS programs. Additional roles of e., one national plan on AIDS; one national coordinating authority for AIDS; and one monitoring and evaluation system for AIDS. In addition, the UN system is expected to strengthen alignment and harmonization of activities of all international organizations and improved accountability and oversight. Remaining challenges identified include increasing awareness of AIDS and reducing stigma and discrimination; reducing vulnerability and risk behaviour among specific groups;providing improved treatment, care and support for people living with HIV; promoting stronger engagement by civil society, and; addressing the gender dimensions of AIDS.     

广西靖西县1997—2012年HIV/AIDS流行病学特征分析

目的了解广西靖西县1997—2012年HIV/AIDS流行病学状况,分析流行趋势,为制定艾滋病防治措施提供科学依据。方法采用描述流行病学分析方法,对靖西县1997—2012年艾滋病疫情监测资料进行分析。结果靖西县1997—2012年累计报告HIV/AIDS 147例,其中HIV感染者60例,AIDS病人47例,死亡40例;男性95例,女性52例,男女性别比为1.83∶1;以20~49岁青壮年为主,这些年龄组发病率为3.24/10万;传播途径以性接触传播为主,占90.48%;其次为静脉注射毒品传播,占6.80%。结论靖西县艾滋病流行近年呈明显上升趋势,艾滋病已经从高危人群向普通人群扩散传播,性接触传播已经成为艾滋病的主要传播途径,应加强对高危人群性行为的干预,遏制艾滋病传播蔓延。     

The chemical bases of the various AIDS epidemics: Recreational drugs,anti-viral chemotherapy and malnutrition

In 1981 a new epidemic of about two-dozen heterogeneous diseases began to strike non-randomly growing numbers of male homosexuals and mostly male intravenous drug users in the US and Europe. Assuming immunodeficiency as the common denominator the US Centers for Disease Control (CDC) termed the epidemic, AIDS, for acquired immunodeficiency syndrome. From 1981-1984 leading researchers including those from the CDC proposed that recreational drug use was the cause of AIDS, because of exact correlations and of drug-specific diseases. However, in 1984 US government researchers proposed that a virus, now termed human immunodeficiency virus (HIV), is the cause of the non-random epidemics of the US and Europe but also of a new, sexually random epidemic in Africa. The virus-AIDS hypothesis was instantly accepted, but it is burdened with numerous paradoxes, none of which could be resolved by 2003: Why is there no HIV in most AIDS patients, only antibodies against it? Why would HIV take 10 years from infection to AIDS? Why is AIDS not self-limiting via antiviral immunity? Why is there no vaccine against AIDS? Why is AIDS in the US and Europe not random like other viral epidemics? Why did AIDS not rise and then decline exponentially owing to antiviral immunity like all other viral epidemics? Why is AIDS not contagious? Why would only HIV carriers get AIDS who use either recreational or anti-HIV drugs or are subject to malnutrition? Why is the mortality of HIV-antibody-positives treated with anti-HIV drugs 7–9%, but that of all (mostly untreated) HIV-positives globally is only 1–4%? Here we propose that AIDS is a collection of chemical epidemics, caused by recreational drugs, anti-HIV drugs, and malnutrition. According to this hypothesis AIDS is not contagious, not immunogenic, not treatable by vaccines or antiviral drugs, and HIV is just a passenger virus. The hypothesis explains why AIDS epidemics strike non-randomly if caused by drugs and randomly if caused by malnutrition, why they manifest in drug- and malnutrition-specific diseases, and why they are not self-limiting via anti-viral immunity. The hypothesis predicts AIDS prevention by adequate nutrition and abstaining from drugs, and even cures by treating AIDS diseases with proven medications.     

Incidence of AIDS and excess of mortality associated with HIV in haemophiliacs in the United Kingdom: report on behalf of the directors of haemophilia centres in the United Kingdom.

OBJECTIVE--To estimate the cumulative incidence of AIDS by time since seroconversion in haemophiliacs positive for HIV and to examine the evidence for excess mortality associated with HIV in those who had not yet been diagnosed as having AIDS. DESIGN--Analysis of data from ongoing national surveys. SETTING--Haemophilia centres in the United Kingdom. PATIENTS--A total of 1201 men with haemophilia who had lived in the United Kingdom during 1980-7 and were positive for HIV. INTERVENTION--None. END POINTS--Diagnosis of AIDS; death in those not diagnosed as having AIDS. MEASUREMENTS AND MAIN RESULTS--Estimation of cumulative incidence of AIDS and number of excess deaths in seropositive patients not diagnosed with AIDS. Median follow up after seroconversion was 5 years 2 months. Eight five patients developed AIDS. Cumulative incidence of AIDS five years after seroconversion was 4% among patients aged less than 25 at first test positive for HIV, 6% among those aged 25-44, and 19% among those aged greater than or equal to 45. There was little evidence that type or severity of haemophilia or type of factor VIII or IX that had caused HIV infection affected the rate of progression to AIDS. Mortality was increased among those who had not been diagnosed as having AIDS, especially among those with "AIDS related complex." Thirteen deaths were observed among 36 patients diagnosed as having AIDS related complex against 0.65 expected, and 34 deaths in 1080 other patients against 22.77 expected; both calculations were based on mortality rates observed in haemophiliacs in the United Kingdom in the late 1970s. CONCLUSIONS--Rate of progression to AIDS depended strongly on age. There is a substantial burden of fatal disease among patients positive for HIV who have not been formally diagnosed as having AIDS.     

树突状细胞在AIDS灵长类动物模型疾病进程中的作用

非人灵长类动物模型在艾滋病(AIDS)发病机制、传播途径、疫苗和药物等方面的研究中具有重要作用。树突状细胞(DC)作为最重要连接先天免疫与获得性免疫的抗原递呈细胞,在AIDS发病进程中扮演着重要的角色。研究非人灵长类AIDS动物模型中DC亚群数量、表型以及功能的变化,对揭示AIDS发病机制具有十分重要的意义。该文将重点总结近些年来DC亚群在AIDS动物模型发病机制中的作用研究进展,为以后的研究提供思路。