共查询到20条相似文献,搜索用时 3 毫秒
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Wada H Abe M Ono K Morimoto T Kawamura T Takaya T Satoh N Fujita M Kita T Shimatsu A Hasegawa K 《Biochemical and biophysical research communications》2008,374(4):731-736
The beneficial effects of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) beyond cholesterol lowering involve their direct actions on vascular smooth muscle cells (VSMCs). However, the effects of statins on phenotypic modulation of VSMCs are unknown. We herein show that simvastatin (Sm) and atorvastatin (At) inhibited DNA synthesis in human aortic VSMCs dose-dependently, while cell toxicity was not observed below the concentration of 1 μM of Sm or 100 nM of At. Stimulating proliferative VSMCs with Sm or At induced the expression of SM-α-actin and SM-MHC, highly specific markers of differentiated phenotype. Sm up-regulated the binding activity of GATA-6 to SM-MHC GATA site and activated the transfected SM-MHC promoter in proliferative VSMCs, while mutating the GATA-6 binding site abolished this activation. Geranylgeranylpyrophosphate (10 μM), an inhibitor of Rho family proteins, abolished the statin-mediated induction of the differentiated phenotype in VSMCs. These findings suggest that statins activate GATA-6 and induce differentiated VSMCs. 相似文献
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Novel blocker of NFAT activation inhibits IL-6 production in human myometrial arteries and reduces vascular smooth muscle cell proliferation 总被引:1,自引:0,他引:1
Nilsson LM Sun ZW Nilsson J Nordström I Chen YW Molkentin JD Wide-Swensson D Hellstrand P Lydrup ML Gomez MF 《American journal of physiology. Cell physiology》2007,292(3):C1167-C1178
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