Transcription Factor Binding to Replicated DNA

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Leveraging Cross-Species Transcription Factor Binding Site Patterns: From Diabetes Risk Loci to Disease Mechanisms

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拟南芥WRKY68转录调控因子的表达谱分析

WRKY基因家族是主要存在于植物中的转录因子,拟南芥中至少有74个成员。根据锌指结构特征和WRKY结构域的数目,可以将WRKY转录因子分为三大类。拟南芥WRKY68属于第Ⅱ类WRKY蛋白。通过GUS染色和qRT PCR分析各组织部位的表达情况,发现WRKY68在根中的表达量是最高的,其次是幼嫩的叶片和老的荚果中。各种处理条件下的表达水平显示,IAA和高温处理后,WRKY68的表达明显上调,PstDC3000、JA、SA、NAA轻微诱导WRKY68的表达,而Botrytis、NaCl、甘露醇、PEG、脱水、ACC、ABA抑制WRKY68的表达,根据以上实验结果,我们推测WRKY68可能参与生长素和温度调控的植物形态建成及发育过程。     

Molecular Modelling of the Antagonist Binding Site on the Adenosine A,Receptor

Abstract

With the aid of molecular modelling both adenosine and adenosine A, receptor antagonists belonging to various chemical classes were compared. A model for the antagonist binding site was developed. As a consequence 1H-imidazo[4, 5-c]-quinolin-4-amines were synthesized, constituting a novel class of potent non-xanthine adenosine receptor antagonists.