超薄前臂皮瓣在鼻部缺损的应用

目的：探讨超薄前臂皮瓣修复鼻部缺损的临床效果,为临床治疗提供依据。方法：回顾性分析我院于2007年1月~2010年12月收治鼻颌面部缺损患者16例,观察患者皮瓣的成活率和并发症发生等情况。结果：超薄前臂皮瓣移植组皮辫成活率为100％,住院天数为（21．5±6．5）d,无并发症发生。16例患者随访6个月~2年,无失访。皮瓣颜色与面部正常皮肤接近,厚度适中,鼻部外形满意。同时前臂切口瘢痕不明显,皮肤感觉无异常。结论：超薄前臂皮瓣在鼻部缺损修复中成活率更高,患者康复快,并发症较少,值得临床推广使用。     

鼻唇沟瘢痕皮瓣修复烧伤后鼻翼缺损的临床研究

目的:探讨鼻唇沟扩张瘢痕皮瓣或瘢痕皮瓣修复烧伤后鼻翼缺损的临床疗效。方法:回顾性分析我院于2006年6月至2012年6月收治的烧伤后鼻翼缺损患者18例。男性10例,女性8例,年龄6~64岁,平均35.3岁。其中面部深Ⅱ度烧伤12例,Ⅲ度烧伤6例;病程8个月~7年。应用鼻唇沟扩张瘢痕皮瓣修复11例,鼻唇沟瘢痕皮瓣修复7例。缺损面积最大者为1.8×2.5 cm2,最小者为0.7×1.3 cm2。结果:术后皮瓣全部成活,无并发症发生。18例鼻翼缺损患者外观均明显改善,皮瓣外形不臃肿,颜色、质地与周围皮肤相近。术后鼻部瘢痕不明显,供区鼻唇沟无明显瘢痕增生。结论:保留残存鼻翼的解剖结构,利用鼻唇沟扩张瘢痕皮瓣或瘢痕皮瓣重建鼻侧背部结构,是鼻翼缺损修复的良好方法。     

三种不同皮瓣修复口腔颌面组织缺损的临床效果

目的:探讨三种皮瓣在口腔面部组织缺损修复中的临床效果。方法:以2014年1月到2014年12月在我院皮瓣修复口腔面部组织缺损患者64例为研究对象。胸大肌皮瓣26例,前臂皮瓣22例,股前外侧皮瓣16例。术后3~12月对患者临床疗效进行观察评价。结果:患者均采用胸大肌皮瓣、股前外侧皮瓣和前臂皮瓣进行口腔面部组织缺损的修复,不同皮瓣来源数量组间比较差异均无统计学意义(P0.05)。患者术后均治愈,移植成功率100%,组间比较差异无统计学意义(P0.05)。少数患者发生积血、感染不良反应情况,总不良反应发生率为12.5%,不同组间的不良反应发生率比较差异无统计学意义(P0.05)。结论:三种不同的皮瓣修复口腔面部组织缺损临床效果均较好,皮瓣的选择较广泛,显著改善了患者口腔生理功能,提高了患者的生活质量,临床推广使用价值高。     

口腔颌面部肿瘤患者术后缺损的外侧皮瓣修复术与前臂皮瓣修复术对比研究

摘要 目的：探讨口腔颌面部肿瘤患者术后缺损的外侧皮瓣修复术与前臂皮瓣修复术对比。方法：选取遂宁市中心医院（我院）2015年8月到2020年8月共收治的120例口腔颌面部肿瘤患者,所有患者通过肿瘤切除术后均出现组织缺损现象,对所有组织缺损的患者依照不同的皮瓣修复方式分为两组,其中应用外侧皮瓣修复术的68例患者分为外侧皮瓣修复组,应用前臂皮瓣修复术的52例患者分为前臂皮瓣修复组,对比两组的皮瓣修复效果,治疗后的口腔功能恢复情况,瓣成活率、术后皮瓣危象率以及血管吻合时间,并发症情况。结果：外侧皮瓣修复组的总有效率为95.59 %,前臂皮瓣修复组的总有效率为84.62 %,外侧皮瓣修复组明显高于前臂皮瓣修复组（P＜0.05）;外侧皮瓣修复组患者的外形修复、语言功能、咀嚼功能、吞咽功能以及口腔闭合评分明显高于前臂皮瓣修复组（P＜0.05）;两组的皮瓣成功率均比较高对比无明显差异（P＞0.05）,两组的术后皮瓣危象率比较低,对比无明显差异（P＞0.05）,血管吻合时间对比无明显差异（P＞0.05）;对比两组并发症发生情况发现,外侧皮瓣修复组的总并发症发生率为2.94 %,前臂皮瓣修复组并发症发生率为17.31 %,外侧皮瓣修复组明显低于前臂皮瓣修复组（P＜0.05）。结论：对口腔颌面部肿瘤患者术后缺损患者应用外侧皮瓣修复术能够提升患者的皮瓣修复效果,提升患者的口腔功能恢复情况,减少并发症的发生,安全性好,值得临床应用推广。     

游离前臂皮瓣移植修复治疗口腔颌面部肿瘤术后缺损的效果

目的研究游离前臂皮瓣移植修复治疗口腔颌面部肿瘤术后缺损的价值。方法选取2014年1月～2018年12月我院收治的36例口腔颌面部肿瘤术后缺损患者,给予游离前臂皮瓣移植修复,观察治疗后2个月皮瓣成活率、并发症情况及吞咽功能,比较患者治疗前后白介素2(IL-2)及唾液酸水平。结果治疗后2个月,患者皮瓣成活率为94.44%(34/36)。并发瘙痒10例(27.78%),瘢痕6例(16.67%),色素沉着17例(47.22%),皮区感觉异常20例(55.56%)。吞咽功能2级7例(19.44%),3级29例(80.56%),无1级和4级患者。治疗后IL-2与唾液酸水平与治疗前比较,差异有统计学意义(P0.05)。结论游离前臂皮瓣移植修复治疗口腔颌面部肿瘤术后缺损效果较好,皮瓣成活率较高,能改善吞咽功能。     

游离股前外侧皮瓣修复眼镜蛇伤致小腿皮肤坏死缺损的临床分析

目的评价游离股前外侧皮瓣修复眼镜蛇咬伤后小腿皮肤坏死缺损的临床价值。方法按游离股前外侧皮瓣修复及其他皮瓣修复方法分组,游离股前外侧皮瓣修复(观察组)20例,其他皮瓣修复(对照组)16例,并对两组效果进行分析。结果完全成活率比较,观察组为95%,对照组为68.75%,差异具有统计学意义(χ2=4.036,P0.05);成活率比较,观察组为100%,对照组为93.75%,差异无统计学意义(χ2=0,P0.05);两组患者小腿软组织缺损面积比较无统计学差异(t=0.03,P0.05)。结论游离股前外侧皮瓣对修复眼镜蛇咬伤后小腿皮肤坏死缺损的效果较好,完全成活率较高。     

VSD用于足踝部皮肤软组织缺损行腓动脉穿支皮瓣修复的效果分析

目的探讨负压封闭引流(vacuum sealing drainage,VSD)用于足踝部皮肤软组织缺损行腓动脉穿支皮瓣修复的临床效果。方法将2014年1月~2016年2月我院收治的24例足踝部皮肤软组织缺损患者采用VSD联合腓动脉穿支皮瓣进行修复,观察治疗后皮瓣成活率、创面愈合效果及踝关节功能改善情况,并对治疗前后美国骨科足踝外科协会(AOFAS)踝-后足评分进行比较。结果治疗后皮瓣成活率为100%,创面、切口Ⅰ期愈合,踝关节功能优良率95.83%,治疗后AOFAS评分高于治疗前(P0.05)。结论 VSD能显著降低创面感染发生率,促进创面愈合和肉芽组织的生长,应用于足踝部皮肤软组织缺损行腓动脉穿支皮瓣修复的效果确切,值得临床推广应用。     

腓动脉穿支皮瓣术修复足踝部皮肤软组织缺损的效果观察

目的观察足踝部皮肤软组织缺损行腓动脉穿支皮瓣术的修复效果。方法对我院2014年3月~2016年4月收治的23例足踝部皮肤软组织缺损患者采用腓动脉穿支皮瓣术进行修复,观察记录踝关节功能、创面愈合效果及皮瓣成活率。结果术后创面Ⅰ期愈合,皮瓣成活率100%,踝关节功能优良率95.65%;治疗后采用美国足踝外科协会(AOFAS)足功能评分为(90.19±8.83)分,高于治疗前的(34.12±11.88)分,差异有统计学意义(P0.05)。结论腓动脉终末穿支皮瓣修复足踝部皮肤软组织缺损的临床效果良好,能显著改善踝关节功能,从而提高足部功能。     

马来酸桂哌齐特与腹部带蒂皮瓣对上肢烧伤组织缺损的修复效果

目的：探讨马来酸桂哌齐特联合腹部带蒂皮瓣治疗手及前臂皮肤软组织烧伤缺损的临床效果。方法：选取我院2011 年2 月 -2013 年2 月收治的68 例手及前臂皮肤软组织烧伤缺损患者作为观察组,行马来酸桂哌齐特结合腹部带蒂皮瓣治疗,另选择同 期接受股前外侧皮瓣修复治疗的50 例患者为对照组。观察并比较两组患者皮瓣修复效果以及神经功能烧伤缺损评分。结果：观 察组患者皮瓣存活率高于对照组,差异具有统计学意义(P<0.05);观察组皮瓣感染率低于对照组,差异具有统计学意义(P<0.05); 观察组皮瓣断蒂时间及神经功能烧伤缺损评分均低于对照组,差异具有统计学意义(P<0.05)。结论：马来酸桂哌齐特结合腹部带 蒂皮瓣治疗具有皮瓣存活率高、神经功能恢复良好,术后恢复快等特点,值得临床推广应用。     

股前外侧皮瓣游离修复头颈肿瘤术后缺损

目的分析游离股前外侧皮瓣修复头颈肿瘤术后缺损的应用效果。方法选择2011年11月~2016年11月在我院行手术治疗的头颈肿瘤患者12例,全部患者均行游离股前外侧皮瓣修复头颈肿瘤切除术后缺损,观察患者术后皮瓣存活和并发症发生情况。结果本组12例患者中,11例(91.7%)Ⅰ期愈合,无皮瓣坏死和伤口感染等并发症;1例(8.3%)皮瓣坏死,经再次手术行胸大肌肌皮瓣修复术后皮瓣成活。结论股前外侧皮瓣游离具有成功率高、供区部位隐蔽、技术可靠和术后并发症少等优势,是修复头颈肿瘤术后缺损较为理想的皮瓣。     

Recent advances in the study of Kaposi's sarcoma-associated herpesvirus replication and pathogenesis

It has now been over twenty years since a novel herpesviral genome was identified in Kaposi's sarcoma biopsies. Since then, the cumulative research effort by molecular biologists, virologists, clinicians, and epidemiologists alike has led to the extensive characterization of this tumor virus, Kaposi's sarcoma-associated herpesvirus(KSHV; also known as human herpesvirus 8(HHV-8)), and its associated diseases. Here we review the current knowledge of KSHV biology and pathogenesis, with a particular emphasis on new and exciting advances in the field of epigenetics. We also discuss the development and practicality of various cell culture and animal model systems to study KSHV replication and pathogenesis.     

The structure, reproduction and taxonomy of Vidalia and Osmundaria (Rhodophyta, Rhodomelaceae)

Comprises species occurring mostly in subtidal habitats in tropical, subtropical and warm-temperate areas of the world. An analysis of the type species, V. spiralis (Sonder) Lamouroux ex J. Agardh, a species from Australia, establishes basic characters for distinguishing species in the genus. These characters are (1) branching patterns of thalli, (2) flat blades that may be spiralled on their axis, (3) width of the blade, (4) primary or secondary derivation of sterile and fertile branchlets and (5) position of sterile and fertile branchlets on the thalli. Application of the latter two characters provides an important basic method for separation of species into three major groups. Osmundaria , a genus known only in southern Australia, was studied in relation to Vidalia , and its separation from the Vidalia assemblage is not accepted. Species of Vidalia therefore are transferred to the older genus name, Osmundaria. Two new species, Osmundaria papenfussii and Osmundaria oliveae are described from Natal. Confusion in the usage of the epithet, Vidalia fimbriala Brown ex Turner has been clarified, and Vidalia gregaria Falkenberg, described as an epiphyte on Osmundaria pro/ifera Lamouroux, is revealed to be young branches of the host, Osmundaria prolifera.     

New or rare chromosome counts in Artemisia L. (Asteraceae, Anthemideae) and related genera from Kazakhstan

Fifteen chromosome counts of six Artemisia taxa and one species of each of the genera Brachanthemum, Hippolytia, Kaschgaria, Lepidolopsis and Turaniphytum are reported from Kazakhstan. Three of them are new reports, two are not consistent with previous counts and the remainder are confirmations of very scarce (one to four) earlier records. All the populations studied have the same basic chromosome number, x = 9, with ploidy levels ranging from 2x to 6x. Some correlations between ploidy level, morphological characters and distribution are noted.     

肝癌中HBV和HCV基因和抗原的分布及意义

采用原位分子杂交方法检测HCV RNA及HBV X基因;采用免疫组织化学方法研究HCV核心抗原,非结构区C33c抗原及HBxAg在肝细胞肝癌中的定位及分布.结果表明(1)HCV RNA、HBV X基因在肝细胞肝癌组织检出率分别为40%(55/136)和82%(112/136).HCV RNA定位于癌细胞的胞浆内,阳性细胞呈散在、灶状及弥漫分布三种形式;HBV X基因在肝癌细胞中的分布呈胞浆型、核型及核浆型,阳性细胞也呈上述三种分布形式;(2)HCV C33c抗原、核心抗原在肝细胞肝癌中的阳性率为81%(133/164)及86%(141/164).C33c抗原定位于癌细胞及肝细胞的胞浆内;核心抗原既定位于癌细胞核中,又可定位于胞浆中.C33c抗原阳性细胞以灶状分布为主;而核心抗原阳性细     

Selection with two alleles and complete dominance

For a plant selection model with frequency-independent viabilities, fertilities and selfing rates, it is shown that apart from global fixation, for certain parameter combinations a protected polymorphism and facultative fixation (either allele may become fixed according to initial frequencies) may both occur. Facultative fixation requires different selling rates for the dominant and recessive type. Protection of the polymorphism requires resource allocation for male and female function. In this connection the problem of purely genetically caused population extinction is discussed.
For general frequency dependence and regular segregation, the chances for establishment of a completely recessive gene are compared to those of a completely dominant gene. It is proven that the process of establishment of the recessive gene, despite a fitness advantage, may be considerably endangered by drift effects if random mating prevails. The recessive gene may reach the same effectivity in establishment as a dominant gene, only if the recessive homozygote mates exclusively with its own type during the period of establishment.