共查询到20条相似文献,搜索用时 31 毫秒
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Identification of c-fos sequences involved in induction by insulin and phorbol esters 总被引:35,自引:0,他引:35
D J Stumpo T N Stewart M Z Gilman P J Blackshear 《The Journal of biological chemistry》1988,263(4):1611-1614
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Role of RNA structures in c-myc and c-fos gene regulations 总被引:1,自引:0,他引:1
M Piechaczyk J M Blanchard A Bonnieu P Fort N Mechti J Rech M Cuny L Marty F Ferré B Lebleu 《Gene》1988,72(1-2):287-295
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H J Rahmsdorf A Sch?nthal P Angel M Litfin U Rüther P Herrlich 《Nucleic acids research》1987,15(4):1643-1659
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Kim-Kaneyama Jr Shibanuma M Nose K 《Biochemical and biophysical research communications》2002,299(3):360-365
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O I Omoike B A Benson M A Chan S H Benedict 《Biochemical and biophysical research communications》1999,262(2):523-529
We previously described a 110-kDa tyrosine phosphoprotein, Sob 1, that regulates formation of the DNA binding complex Band A at the c-fos serum response element (SRE) during T cell activation. Using competition and mutant oligonucleotide analysis, we have determined that both the core CArG box of the c-fos SRE and the 3' sequences flanking the CArG box are necessary for stable Band A complex formation. Moreover, using transient transfection and reporter assays, we show that mutations affecting Band A complex formation in vitro also impaired serum induction of c-fos gene expression in vivo. Since mutation at this site has no effect on SRF binding, our results suggest that in combination with SRE/SRF, Sob 1-regulated factor(s) bind at the 3' side of SRE to form Band A, and this confers maximal serum induction of c-fos gene expression via the SRE. 相似文献