共查询到20条相似文献,搜索用时 7 毫秒
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Critical loss of CBP/p300 histone acetylase activity by caspase-6 during neurodegeneration 总被引:12,自引:0,他引:12
Rouaux C Jokic N Mbebi C Boutillier S Loeffler JP Boutillier AL 《The EMBO journal》2003,22(24):6537-6549
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Structure and chemistry of the p300/CBP and Rtt109 histone acetyltransferases: implications for histone acetyltransferase evolution and function 总被引:1,自引:0,他引:1
The recent structure and associated biochemical studies of the metazoan-specific p300/CBP and fungal-specific Rtt109 histone acetyltransferases (HATs) have provided new insights into the ancestral relationship between HATs and their functions. These studies point to a common HAT ancester that has evolved around a common structural framework to form HATs with divergent catalytic and substrate-binding properties. These studies also point to the importance of regulatory loops within HATs and autoacetylation in HAT function. Implications for future studies are discussed. 相似文献
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Gusterson RJ Jazrawi E Adcock IM Latchman DS 《The Journal of biological chemistry》2003,278(9):6838-6847
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