Non-thermal factors are important in the control of skin blood flow during exercise only under high physiological strain

Several authors have argued that skin blood flow (SkBF) during exercise is less than during rest at the same levels of body core and whole-body skin temperatures (Tc and Tsk). Since such an effect does not prevent SkBF during exercise from rising above pre-exercise levels, it is sometimes called a relative cutaneous vasoconstriction. Such a vasoconstriction is considered to be either part of a thermoregulatory adjustment during exercise (elevated thermoregulatory "set-point") or a compensatory response to allow adequate perfusion of exercising muscle. In this paper, some of the pertinent experimental evidence is reviewed, and the following conclusions are reached: the evidence does not support a change in thermoregulatory set-point during exercise; under conditions of high physiological strain (high Tsk and intense exercise), there is quite clearly a relative cutaneous vasoconstrictor effect of exercise; the evidence does not support such an effect under more moderate conditions; and it is likely that, under mild to moderate conditions, other compensatory cardiovascular responses are sufficient to allow adequate perfusion of exercising muscle and are invoked in preference to relative cutaneous vasoconstriction, which has been demonstrated only at higher levels of strain. The thermoregulatory SkBF required during sustained exercise is thus maintained as much as possible.     

Thermal adjustment to cold-water exposure in exercising men and women

Thermoregulatory responses were studied in 10 men and 8 women during 36-W exercise for 1 h in air and water at 20, 24, and 28 degrees C. Men were classified as high (27.6%; n = 2), average (16.8%; n = 4), and low (9.2%; n = 4) percent body fat, whereas women were classified as average (25.2%; n = 4) and low (18.5%; n = 4) fat. For both men and women, exercise of about 1.7 l O2 X min-1 was beneficial in either preventing or retarding the fall in rectal temperature (Tre) observed in a previous study for the same subjects at rest. The greatest thermal strain was noted for the leanest subjects. However, in no instance did exercise facilitate a drop in Tre compared with resting conditions. Despite a larger surface area-to-mass ratio (P less than 0.05) and less effective thermoregulation for women at rest compared with men, essentially similar thermoregulatory responses were observed for both sexes during exercise at each water temperature. For both the men and women, the thermoregulatory benefits of exercise were due largely to the added heat production from physical activity. For the female, an additional benefit of exercise may in part be derived from a more favorable distribution of subcutaneous fat over the active musculature.     

The effects of creatine loading on thermoregulation and intermittent sprint exercise performance in a hot humid environment

The purpose of this study was to determine the effects creatine (Cr) loading may have on thermoregulatory responses during intermittent sprint exercise in a hot/humid environment. Ten physically active, heat-acclimatized men performed 2 familiarization sessions of an exercise test consisting of a 30-minute low-intensity warm-up followed by 6 x 10 second maximal sprints on a cycle ergometer in the heat (35 degrees C, 60% relative humidity). Subjects then participated in 2 different weeks of supplementation. The first week, subjects ingested 5 g of a placebo (P, maltodextrin) in 4 flavored drinks (20 g total) per day for 6 days and were retested on day 7. The second week was similar to the first except a similar dose (4 x 5 g/day) of creatine monohydrate (Cr) replaced maltodextrin in the flavored drinks. Six days of Cr supplementation produced a significant increase in body weight (+1.30 +/- 0.63 kg), whereas the P did not (+0.11 +/- 0.52 kg). Compared to preexercise measures, the exercise test in the heat produced a significant increase in core temperature, a loss of body water determined by body weight change during exercise, and a relative change in plasma volume (%PVC); however, these were not significantly different between P and Cr. Sprint performance was enhanced by Cr loading. Peak power and mean power were significantly higher during the intermittent sprint exercise test following 6 days of Cr supplementation. It appears that ingestion of Cr for 6 days does not produce any different thermoregulatory responses to intermittent sprint exercise and may augment sprint exercise performance in the heat.     

Thermoregulatory responses of lower limb amputees during exercise in a hot environment

Lower limb amputees (LLAs) have less skin surface required for sweating; thus, the ability to dissipate heat from the body may decrease and the risk of heat illness may increase during exercise in a hot environment. However, no study has compared the thermoregulatory responses during exercise between LLAs and able-body (AB) individuals with different body surface areas. This study aimed to compare the thermoregulatory responses of LLAs with those of AB individuals during exercise in a hot environment. Seven LLAs (LLA group) and 7 able-body individuals (AB group) participated in the study. A 60% peak power output of arm crank upper-body exercise was performed for 60 min in a hot environment (32 °C, 50% relative humidity). There was no difference in the increase in rectal temperature (LLA: 0.8 ± 0.2 °C, AB: 0.8  ± 0.2 °C) and mean skin temperature between the groups during the 60-min exercise. In the LLA group, the accumulated local sweat rate of the thigh during exercise was significantly higher on the non-cut side than on the cut side (64.6 ± 43.0 mg/h vs. 37.0 ± 27.2 mg/h, p < 0.05). The total sweat rate was significantly higher in the LLA group than in the AB group (1.18 ± 0.37 kg/h vs. 0.84 ± 0.10 kg/h, p < 0.05). Thermal sensation and comfort were lower in the LLA group than in the AB group. Different heat loss responses were observed in the AB and LLA groups during exercise in the heat. The LLA group compensates for sweating on the cut side due to an increase in sweat loss on the intact limb, thereby preserving appropriate thermoregulation during exercise.     

Evaluation of two cold thermoregulatory models for prediction of core temperature during exercise in cold water.

Cold thermoregulatory models (CTM) have primarily been developed to predict core temperature (T(core)) responses during sedentary immersion. Few studies have examined their efficacy to predict T(core) during exercise cold exposure. The purpose of this study was to compare observed T(core) responses during exercise in cold water with the predicted T(core) from a three-cylinder (3-CTM) and a six-cylinder (6-CTM) model, adjusted to include heat production from exercise. A matrix of two metabolic rates (0.44 and 0.88 m/s walking), two water temperatures (10 and 15 degrees C), and two immersion depths (chest and waist) were used to elicit different rates of T(core) changes. Root mean square deviation (RMSD) and nonparametric Bland-Altman tests were used to test for acceptable model predictions. Using the RMSD criterion, the 3-CTM did not fit the observed data in any trial, whereas the 6-CTM fit the data (RMSD less than standard deviation) in four of eight trials. In general, the 3-CTM predicted a rapid decline in core temperature followed by a plateau. For the 6-CTM, the predicted T(core) appeared relatively tight during the early part of immersion, but was much lower during the latter portions of immersion, accounting for the nonagreement between RMSD and SD values. The 6-CTM was rerun with no adjustment for exercise metabolism, and core temperature and heat loss predictions were tighter. In summary, this study demonstrated that both thermoregulatory models designed for sedentary cold exposure, currently, cannot be extended for use during partial immersion exercise in cold water. Algorithms need to be developed to better predict heat loss during exercise in cold water.     

Thermoregulatory responses of middle-aged and young men during dry-heat acclimation

Thermoregulatory responses during heat acclimation were compared between nine young (mean age 21.2 yr) and nine middle-aged men (mean age 46.4 yr) who were matched (P greater than 0.05) for body weight, surface area, surface area-to-weight ratio, percent body fat, and maximal aerobic power. After evaluation in a comfortable environment (22 degrees C, 50% relative humidity), the men were heat acclimated by treadmill walking (1.56 m/s, 5% grade) for two 50-min exercise bouts separated by 10 min of rest for 10 consecutive days in a hot dry (49 degrees C ambient temperature, 20% relative humidity) environment. During the first day of heat exposure performance time was 27 min longer (P less than 0.05) for the middle-aged men, whereas final rectal and skin temperatures and heart rate were lower, and final total body sweat loss was higher (P less than 0.05) compared with the young men. These thermoregulatory advantages for the middle-aged men persisted for the first few days of exercise-heat acclimation (P less than 0.05). After acclimation no thermoregulatory or performance time differences were observed between groups (P greater than 0.05). Sweating sensitivity, esophageal temperature at sweating onset, and the sweating onset time did not differ (P greater than 0.05) between groups either pre- or postacclimatization. Plasma osmolality and sodium concentration were slightly lower for the young men both pre- and postacclimatization; however, both groups had a similar percent change in plasma volume from rest to exercise during these tests.(ABSTRACT TRUNCATED AT 250 WORDS)     

Effects of two cooling strategies on thermoregulatory responses of tetraplegic athletes during repeated intermittent exercise in the heat.

Athletes with spinal cord injury (SCI), and in particular tetraplegia, have an increased risk of heat strain and consequently heat illness relative to able-bodied individuals. Strategies that reduce the heat strain during exercise in a hot environment may reduce the risk of heat illness. To test the hypotheses that precooling or cooling during intermittent sprint exercise in a heated environment would attenuate the rise in core temperature in tetraplegic athletes, eight male subjects with SCI (lesions C(5)-C(7); 2 incomplete lesions) undertook four heat stress trials (32.0 +/- 0.1 degrees C, 50 +/- 0.1% relative humidity). After assessment of baseline thermoregulatory responses at rest for 80 min, subjects performed three intermittent sprint protocols for 28 min. All trials were undertaken on an arm crank ergometer and involved a no-cooling control (Con), 20 min of precooling (Pre), or cooling during exercise (Dur). Trials were administered in a randomized order. After the intermittent sprint protocols, mean core temperature was higher during Con (37.3 +/- 0.3 degrees C) compared with Pre and Dur (36.5 +/- 0.6 degrees C and 37.0 +/- 0.5 degrees C, respectively; P < 0.01). Moreover, perceived exertion was lower during Pre (13 +/- 2; P < 0.01) and Dur (12 +/- 1; P < 0.01) compared with Con (14 +/- 2). These results suggest that both precooling and cooling during intermittent sprint exercise in the heat reduces thermal strain in tetraplegic athletes. The cooling strategies also appear to show reduced perceived exertion at equivalent time points, which may translate into improved functional capacity.     

Thermoregulation during exercise in relation to sex and age

The thermoregulatory responses to 1 h exercise of 14 male (age range 18--65 year) and 7 female (age range 18--46 year) athletes and 4 (3 male and 1 female) non-athletic subjects have been investigated in a moderate environment (Tdb = 21 degrees C, Twb = 15 degrees C and rh less than 50%) and analysed in relation to age, sex, and maximum aerobic power output (VO2max). The maximal sweat loss (Msw max) under the given conditions was closely related (r = + 0.90) to VO2max and for a given relative work load (%VO2max), rectal (Tre) and mean skin (Tsk) temperatures was the same in all subjects. Sweat loss (Msw) was linearly related to total heat production (H) and to peripheral tissue heat conductance (K) and if expressed in relative terms (%Mswmax) was linearly related to Tre. For a given Tre relative sweat rate was identical in the groups studied. From these results it would seem that during exercise Tre rises to meet the requirements of heat dissipation by establishing a thermal gradient from core to skin and stimulating sweating in proportion to maximal capacity of the system. Thus provided the thermal responses to work were standardised using the appropriate physiological variables, there was no evidence to be found for differences in thermoregulatory function which could be ascribed to sex or age.     

Evidence for thermoregulatory behavior during self-paced exercise in the heat

The primary objective of this investigation was to test the hypothesis that voluntary reductions in exercise intensity in heat improve heat exchange between the body and the environment, and are thus thermoregulatory behaviors. This was accomplished by observing the conscious selection of exercise intensity and the accompanying thermal outcomes of eleven moderately active males when exposed to an uncompensably hot (UNCOMP) and a compensable (COMP) thermal environment. Evidence for thermoregulatory behavior was defined relative to the specific, pre-determined definition. Self-selected exercise intensity (power output) was unanimously reduced in UNCOMP over time and relative to COMP in all the subjects. These voluntary responses were found to modify metabolic heat production over time and therefore heat exchange between the body and the environment. Likewise, the observed reductions in power output were, at least in part, due to a conscious action, that was found to be inversely related to the total body heat storage and thermal discomfort. There was no evidence for thermoregulatory behavior in COMP. These data uniquely indicate that voluntary reductions in exercise intensity improves heat exchange over time, and therefore contributes to the regulation of body temperature. These findings suggest that reductions in exercise intensity in heat are, by definition, thermoregulatory behaviors.     

The endocrine response and substrate utilization during exercise in children and adolescents.

Adolescence is a time of rapid growth caused by significant changes in hormone levels. For many, it is also a time of increased physical activity and sport that places a large demand on energy reserves. Exercise is known to cause perturbations in endocrine and metabolic systems in children and adolescents, yet careful characterization of these responses is only now being conducted. It does not appear that prepubertal youth have a different muscle composition than adults. However, these youth do have a lower anaerobic capacity and a greater reliance on aerobic metabolism during activity. Prepubertal adolescents may have an immature glucose regulatory system that influences glycemic regulation at the onset of moderate exercise. During heavy exercise, muscle and blood lactate levels are lower in children than in adults and there is a greater reliance on fat as fuel. The exercise intensity that causes maximal fat oxidation rate and the relative rate of fat oxidation decreases as adolescents develop through puberty. The mechanism for the attenuated lipid utilization with the advancement of puberty, and the impact that this may have on body composition, are unknown. Surprisingly, prepubertal adolescents have relatively high rates of exogenous glucose oxidation, perhaps because of their smaller endogenous carbohydrate reserves. Further study is needed to determine the optimal exogenous carbohydrate feeding regimen for peak performance in adolescence. Studies are also needed to determine whether physical activity, at an intensity targeted to maximize fat oxidation, help to lower body adiposity in overweight youth.     

Exertion-induced fatigue and thermoregulation in the cold

Cold exposure facilitates body heat loss which can reduce body temperature, unless mitigated by enhanced heat conservation or increased heat production. When behavioral strategies inadequately defend body temperature, vasomotor and thermogenic responses are elicited, both of which are modulated if not mediated by sympathetic nervous activation. Both exercise and shivering increase metabolic heat production which helps offset body heat losses in the cold. However, exercise also increases peripheral blood flow, in turn facilitating heat loss, an effect that can persist for some time after exercise ceases. Whether exercise alleviates or exacerbates heat debt during cold exposure depends on the heat transfer coefficient of the environment, mode of activity and exercise intensity. Prolonged exhaustive exercise leading to energy substrate depletion could compromise maintenance of thermal balance in the cold simply by precluding continuation of further exercise and the associated thermogenesis. Hypoglycemia impairs shivering, but this appears to be centrally mediated, rather than a limitation to peripheral energy metabolism. Research is equivocal regarding the importance of muscle glycogen depletion in explaining shivering impairments. Recent research suggests that when acute exercise leads to fatigue without depleting energy stores, vasoconstrictor responses to cold are impaired, thus body heat conservation becomes degraded. Fatigue that was induced by chronic overexertion sustained over many weeks, appeared to delay the onset of shivering until body temperature fell lower than when subjects were rested, as well as impair vasoconstrictor responses. When heavy physical activity is coupled with underfeeding for prolonged periods, the resulting negative energy balance leads to loss of body mass, and the corresponding reduction in tissue insulation, in turn, compromises thermal balance by facilitating conductive transfer of body heat from core to shell. The possibility that impairments in thermoregulatory responses to cold associated with exertional fatigue are mediated by blunted sympathetic nervous responsiveness to cold is suggested by some experimental observations and merits further study.     

The importance of aerobic fitness in determining tolerance to uncompensable heat stress

When protective clothing is worn that restricts evaporative heat loss, it is not valid to assume that the higher sweat rates associated with improvements in aerobic fitness will increase heat tolerance. An initial study compared thermoregulatory and cardiovascular responses to both compensable and uncompensable heat stress before and after 8 weeks of endurance training in previously sedentary males. Despite a 15% improvement in VO2peak, and lower heart rates and rectal temperature (T(re)) responses while wearing combat clothing, no changes were noted when subjects wore a protective clothing ensemble. Tolerance times were unchanged at approximately 50 min. A subsequent short-term training model that used daily 1-h exercise sessions for 2 weeks also failed to show any benefit when the protective clothing was worn in the heat. Cross-sectional comparisons between groups of high and low aerobic fitness, however, have revealed that a high aerobic fitness is associated with extended tolerance time when the protective clothing is worn. The longer tolerance time is a function of both a lower starting T(re) and a higher T(re) tolerated at exhaustion. Improvements in cardiovascular function with long-term training may allow higher core temperatures to be reached prior to exhaustion. Conversely, elevations in core temperature that occur with normal training sessions may familiarize the more fit subjects to the discomforts of exercise in the heat. Other factors such as differences in body fatness may account for a faster increase in tissue temperature at a given metabolic rate for less fit individuals.     

Rehydration with glycerol: endocrine, cardiovascular, and thermoregulatory responses during exercise in the heat.

The impact of rehydration with glycerol on cardiovascular and thermoregulatory responses during exercise in the heat was studied in eight highly trained male cyclists. Each subject completed three dehydration-rehydration experimental trials that differed only in the rehydration treatment, each separated by 7 days. Before each experimental day, subjects dehydrated to -4% of their body weight by exercise and water restriction. The experimental treatments were as follows: no fluid (NF), glycerol bolus (1 g/kg body wt) followed by water (G), and water alone (W). Rehydration (3% body weight) was given over an 80-min period. After rehydration, subjects cycled (74% peak O2 uptake) to exhaustion in a hot and wet (37 degrees C and 48% relative humidity) environment. For G, plasma volume was expanded (P < 0.05) during rehydration and remained higher than W (P < 0.05) during exercise. Exercise time to exhaustion during G (33 +/- 4 min) was longer (P < 0.05) compared with both W (27 +/- 3 min) and NF (19 +/- 3 min). Cutaneous vascular conductance was significantly elevated (P < 0.05) during G, but G provided no other thermoregulatory or cardiovascular benefits compared with W and NF. Fluid-regulating hormones (vasopressin, aldosterone, atriopeptin, and plasma renin activity) decreased during rehydration and increased during exercise (except atriopeptin), but there were no differences between G and W. These data indicated that glycerol had little or no major effect on fluid-regulating factors during rehydration or exercise, and the improved exercise capacity in G was likely due to a greater plasma volume during exercise.     

Calorimetric study of the effect of salicylate in man during heat exposure and exercise (author's transl)]

1. The effect of sodium acetylo-salicylate (2 g per os) on the thermoregulatory responses of 10 male subjects was studied by direct and indirect calorimetry during two tests : heat exposure at 37 degrees C and exercise (50 W) at 25 degrees C. Both test were performed twice : with salicylate treatment and with a placebo. 2. During heat exposure at 37 degrees C for 75 min, the rise in tympanic temperature (Tty) and in mean skin temperature Ts, the time course of heat losses by radiation (R), convection (C) and evaporation (E), and the metabolic rate (M), measured by oxygen consumption, were not altered by salicylate treatment. 3. During exercise, salicylate treatment did not affect the time course of Tty and Ts, (R + C) and M. However, salicylate treatment decreased the delay for triggering the evaporative response (E) to the thermal load; similarly, the increase in cutaneous blood flow was triggered sooner in subjected receiving salicylate than in controls. 4. In conclusion, these results suggest that, during exercise, the thermal controller triggers thermoregulatory responses during passive hyperthermia by heat exposure.     

Thermoregulatory responses during exercise and a hot water immersion and the affective responses to peripheral thermal stimuli

Tympanic (Tty), mean skin (¯Tsk) and mean body (¯Tb) temperatures and heart rate (HR) increased more in low Vo₂ max group (LG) than in high Vo₂ max group (HG) during exercise. The regression coefficient of body temperatures (Tty and ¯Tb) on HR and the increased rate of heat storage were larger in LG than in HG during exercise. The local sweat rate (per min/cm²) during a hot water bath exhibited a considerable large quantity in comparison with the amount during exercise. Internal and skin temperatures during a hot water bath increased more immediately than those during exercise. The levels of comfort sensation during the preovulatory phase in women and pre-exercise period in men were higher at 40C than at 20C as peripheral thermal stimulus. The levels during the postovulatory and post-exercise phases in the same subjects were higher with the cool stimuli than with the warm stimuli. Above results suggest that thermoregulatory responses during submaximal exercise are different according to physical fitness and that these responses are different from those during hot water immersion. In addition, these suggest that the scores of thermal sensation with warm and cool stimuli are different during the pre- and post-ovulatory phases and the pre- and post-exercise periods.     

Enhanced glucose availability for working muscles reduces exercise hyperthermia in dogs

Body temperature and metabolic responses to 2 h treadmill exercise in dogs given glucose intravenously (25-30 mg.kg-1 X min-1 throughout the run) were compared with those measured in the same animals with elevated plasma FFA concentrations (soya bean oil ingestion + intravenous heparin) and in control experiments (24 h fasting). In comparison with control conditions enhanced glucose availability for the working muscles caused a reduction in the exercise-induced increases in both rectal (by 0.9 +/- 0.11 degree C) and muscle (by 0.9 +/- 0.16 degree C) temperatures, a lower rate of oxygen uptake (by 16%) and an elevated respiratory exchange ratio. A tendency towards enhanced body temperature responses to exercise, accompanied by increases in VO2 and cardiac frequency was noted in dogs with elevated plasma FFA concentrations as compared with the control animals. The estimated amount of heat effectively dissipated from the body, expressed as a fraction of heat load (thermoregulatory efficiency) was significantly higher in dogs infused with glucose (0.962 +/- 0.0035), than in the controls (0.947 +/- 0.0043) and those with elevated plasma FFA concentrations (0.931 +/- 0.0029). It is concluded that the increased contribution of carbohydrates to the energy yield during exercise results in a marked attenuation of hyperthermia, associated with a reduced metabolic rate and improved thermoregulatory efficiency.     

Thermoregulatory responses to upper body exercise

The purpose of this study was to compare thermoregulatory responses between upper body and lower body exercise. Nine male subjects performed 60 min of arm crank (AC) and cycle (CY) exercise at the same absolute intensity (oxygen uptake = 1.61 X min-1) and at the same relative intensity (60% of ergometer specific peak oxygen uptake) in a temperate (24 degrees C, 20% rh) environment. During the absolute intensity experiments, rectal temperature and sweating rate responses were essentially the same for both modes of exercise. In addition, no differences were found for chest, back, arm, or thigh skin temperatures, but calf skin temperature was significantly (P less than 0.05) lower during arm crank than cycle exercise. During the relative intensity experiments, thermoregulatory responses were lower during arm crank than cycle exercise. In addition, we found no difference between esophageal and rectal temperature values elicited by arm crank exercise. These results indicate that the examined thermoregulatory responses are independent of the skeletal muscle mass employed and dependent upon the absolute metabolic intensity.     

Effects of menstrual cycle and physical training on heat loss responses during dynamic exercise at moderate intensity in a temperate environment

We evaluated the effects of the menstrual cycle and physical training on heat loss (sweating and cutaneous vasodilation) responses during moderate exercise in a temperate environment. Ten untrained (group U) and seven endurance-trained (group T) women (maximal O2 uptake of 36.7+/-1.1 vs. 49.4+/-1.7 ml.kg-1.min-1, respectively; P<0.05) performed a cycling exercise at 50% maximal O2 uptake for 30 min during both the midfollicular and midluteal menstrual phase in a temperate environment (ambient temperature of 25 degrees C, relative humidity of 45%). In group U, plasma levels of estrone, estradiol, and progesterone at rest and esophageal temperature (Tes) during exercise were significantly higher during the midluteal than during the midfollicular phase (P<0.05). Sweating rate and cutaneous blood flow (measured via laser-Doppler flowmetry) on the chest, back, forearm, and thigh were lower during the midluteal than during the midfollicular phase during exercise. Tes threshold for heat loss responses was significantly higher and sensitivity of the heat loss responses was significantly lower in the midluteal than in the midfollicular phase, regardless of body site. These effects of the menstrual cycle in group U were not observed in group T. The sweating rate and cutaneous blood flow were significantly higher in group T than in group U, regardless of menstrual phase or body site. Tes threshold for heat loss responses was significantly lower and sensitivity of heat loss responses was significantly greater in group T than in group U in the midluteal phase; however, sensitivity of the sweating response was significantly greater in the midfollicular phase. These results suggest that heat loss responses in group U were inhibited in the midluteal phase compared with in the midfollicular phase. Menstrual cycle had no remarkable effects in group T. Physical training improved heat loss responses, which was more marked in the midluteal than in the midfollicular phase.     

Thermoregulation in the Aging Population and Practical Strategies to Overcome a Warmer Tomorrow

As global temperatures continue to rise, improving thermal tolerance in the aged population is crucial to counteract age‐associated impairments in thermoregulatory function. Impairments in reflex cutaneous vasodilation and sweating response can augment the vulnerability of older adults to heat‐related injuries following exposure to heat stress. Mechanisms underlying a compromised cutaneous vasodilation are suggested to include reduced sympathetic neural drive, diminished cholinergic co‐transmitter contribution, and altered second messenger signaling events. On the other hand, impairments in sweating response are ascribed to reduced sweat gland cholinergic sensitivity and altered cyclooxygenase and nitric oxide signaling. Several practical mitigation strategies such as exercise, passive heating, and behavioral adaptations are proposed as means to overcome heat stress and improve thermal tolerance in the aged. Aerobic exercise training is shown to be amongst the most effective ways to enhance thermoregulatory function. However, in elderly with limited exercise capability due to chronic diseases and mobility issues, passive heating can serve as a functional alternative as it has been shown to confer similar benefits to that of exercise training. Supplementary to exercise training and passive heating, behavioral adaptations can be applied to further enhance the heat‐preparedness of the aged.     

Rehydration with fluid of varying tonicities: effects on fluid regulatory hormones and exercise performance in the heat.

This study examined the effects of rehydration (Rehy) with fluids of varying tonicities and routes of administration after exercise-induced hypohydration on exercise performance, fluid regulatory hormone responses, and cardiovascular and thermoregulatory strain during subsequent exercise in the heat. On four occasions, eight men performed an exercise-dehydration protocol of approximately 185 min (33 degrees C) to establish a 4% reduction in body weight. Following dehydration, 2% of the fluid lost was replaced during the first 45 min of a 100-min rest period by one of three random Rehy treatments (0.9% saline intravenous; 0.45% saline intravenous; 0.45% saline oral) or no Rehy (no fluid) treatment. Subjects then stood for 20 min at 36 degrees C and then walked at 50% maximal oxygen consumption for 90 min. Subsequent to dehydration, plasma Na(+), osmolality, aldosterone, and arginine vasopressin concentrations were elevated (P < 0.05) in each trial, accompanied by a -4% hemoconcentration. Following Rehy, there were no differences (P > 0.05) in fluid volume restored, post-rehydration (Post-Rehy) body weight, or urine volume. Percent change in plasma volume was 5% above pre-Rehy values, and plasma Na(+), osmolality, and fluid regulatory hormones were lower compared with no fluid. During exercise, skin and core temperatures, heart rate, and exercise time were not different (P > 0.05) among the Rehy treatments. Plasma osmolality, Na(+), percent change in plasma volume, and fluid regulatory hormones responded similarly among all Rehy treatments. Neither a fluid of greater tonicity nor the route of administration resulted in a more rapid or greater fluid retention, nor did it enhance heat tolerance or diminish physiological strain during subsequent exercise in the heat.