共查询到20条相似文献,搜索用时 31 毫秒
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J B Natvig 《The Biochemical journal》1970,117(2):2P-3P
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Canine immunoglobulins. IV. Copro-immunoglobulins 总被引:1,自引:0,他引:1
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Long-acting thyroid stimulator (LATS) and LATS protector (LATS-P) were assayed at or near delivery in serum from 18 pregnant women with a history of past or present thyrotoxicosis. The results suggested that neonatal thyrotoxicosis may be predicted prenatally if maternal serum LATS and LATS-P concentrations near delivery are above certain levels. 相似文献
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C Milstein 《The Biochemical journal》1968,110(3):26P-27P
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Duck immunoglobulins. II. Biologic and immunochemical studies 总被引:1,自引:0,他引:1
H M Grey 《Journal of immunology (Baltimore, Md. : 1950)》1967,98(4):820-826
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Experimental murine amyloid. IV. Amyloidosis and immunoglobulins 总被引:7,自引:0,他引:7
J T Willerson R Asofsky W F Barth 《Journal of immunology (Baltimore, Md. : 1950)》1969,103(4):741-749
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Macrophage-cytophilic antibodies and the functions of macrophage-bound immunoglobulins. 总被引:5,自引:0,他引:5
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I R Tizard 《Microbiological reviews》1971,35(4):365-378
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H Krotkiewski 《Acta biochimica Polonica》1999,46(2):341-350
Most of glycoproteins described so far, including immunoglobulins, are glycosylated during post-translational modifications of protein molecules. Current knowledge of the structure of sugar chains in immunoglobulin molecules and their biological role in health and pathology is reviewed. 相似文献
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Evaluation of immunoglobulins from plant cells. 总被引:3,自引:0,他引:3
Expression of cDNA constructs encoding full-length mouse immunoglobulin chains with their native leader sequences or fusion constructs substituting the native leader with a pre-pro sequence derived from Saccharomyces cerevisiae yielded blocked N-termini on the gamma chain or the correct amino terminal sequence on the mature kappa chain. Lectin binding assays revealed that assembled immunoglobulin complexes contained a glycosylated heavy chain. The attached glycan was resistant to digestion by endoglycosidase H and its lectin binding pattern was distinguishable from that of the mammalian glycan. The results indicated processing of the immunoglobulin carbohydrate in the tobacco Golgi to yield a complex oligosaccharide. Secretion of antibody by protoplasts isolated from regenerated transgenic plants or from suspension callus cells was demonstrated by pulse-chase labeling experiments. When purified, the tobacco-produced antibody was found to possess the antigen binding and catalytic properties of the murine monoclonal antibody. Kinetic parameters (Km, Ki, Vmax, and kcat) of the tobacco-derived antibody were comparable to those of the mouse-derived antibody. The results in general show that the endomembrane system of tobacco cells possesses cognate mechanisms for the recognition of diverse leader sequences. These signals can be used to initiate the assembly, processing, and secretion by plant cells of complex foreign proteins. 相似文献