New antibiotics from Nature’s chemical inventory

The doom and gloom of antibiotic resistance dominates public perception of this drug class. Many believe the world has entered the post-antibiotic era. Classic and modern approaches to antibacterial drug discovery have delivered a plethora of lead molecules with a great majority being natural products of ancient microbial origin. The failure of antibiotics in the resistance era comes from an inability to develop new leads into clinical candidates, which is a costly and risky endeavor for any therapeutic area, especially when resistance is at play. The world needs new antibiotic molecules to replace the exhausted pipeline and the second ‘golden era’ is certain to come from Nature’s chemical inventory once again.     

On Nature’s Strategy for Assigning Genetic Code Multiplicity

Genetic code redundancy would yield, on the average, the assignment of three codons for each of the natural amino acids. The fact that this number is observed only for incorporating Ile and to stop RNA translation still waits for an overall explanation. Through a Structural Bioinformatics approach, the wealth of information stored in the Protein Data Bank has been used here to look for unambiguous clues to decipher the rationale of standard genetic code (SGC) in assigning from one to six different codons for amino acid translation. Leu and Arg, both protected from translational errors by six codons, offer the clearest clue by appearing as the most abundant amino acids in protein-protein and protein-nucleic acid interfaces. Other SGC hidden messages have been sought by analyzing, in a protein structure framework, the roles of over- and under-protected amino acids.     

A Rosetta Stone for Nature’s Benefits to People

After a long incubation period, the Intergovernmental Platform on Biodiversity and Ecosystem Services (IPBES) is now underway. Underpinning all its activities is the IPBES Conceptual Framework (CF), a simplified model of the interactions between nature and people. Drawing on the legacy of previous large-scale environmental assessments, the CF goes further in explicitly embracing different disciplines and knowledge systems (including indigenous and local knowledge) in the co-construction of assessments of the state of the world’s biodiversity and the benefits it provides to humans. The CF can be thought of as a kind of “Rosetta Stone” that highlights commonalities between diverse value sets and seeks to facilitate crossdisciplinary and crosscultural understanding. We argue that the CF will contribute to the increasing trend towards interdisciplinarity in understanding and managing the environment. Rather than displacing disciplinary science, however, we believe that the CF will provide new contexts of discovery and policy applications for it.     

Merleau-Ponty’s Concept of Nature and the Ontology of Flesh

The essay attempts to delineate how Maurice Merleau-Ponty’s phenomenology of perception can be applied to theories of sign processes, and how it reworks the framework of the phenomenalist conception of communication. His later philosophy involved a reformulation of subjectivity and a resolution of the subject/object dualism. My claim is that this non-reductionist theory of perception reveals a different view of nature as we experience it in an expressive and meaningful interaction. The perspective that another living being has and communicates entails a form of depth, the invisible dimension of the visible or audible. These two aspects of perception and dialogue are intertwined in a dialectic of presence and absence, so that sense arises in the perceptual field rather than in subjectivity. This, I argue, is the most fundamental result of his theory. The origination of meaning in the workings of the chiasm of visible and invisible in perception opens up an objective sense of intersubjective nature. The essay also deals with the role of the phenomenological reduction; a suspension of beliefs and existence claims in experience. The reduction enables us to take a step back and look more closely at our understanding of nature in light of the historical and cultural influence on our thinking.     

Spirits of Uncertainty: Eventologies of Nature on China’s Frontiers

ABSTRACT

Studies of the environmental spirit world have been pursuing two main lines of inquiry: (1) that indigenous claims on ecological thought, including beliefs in chthonic spirits and mountain deities, are the outcome of a global process of abstraction and the commoditisation of nature which acts as technology of governmentality for the production of discursive formations through which neoliberal environmental subjectivities can emerge and (2) that the pitfalls of the nature/culture dualism can be avoided by giving priority to nonhuman subjectivities and positing sociologies of nature as subordinate to ontologies of the self-other divide or action-orienting cosmologies of local ‘nature’. The contributors of this collection engage with the spirit worlds and other invisible agents that constitute the everyday landscape of a number of ethnic groups in western China. While declining to engage with the notion of animism or subscribing to totalising ‘cosmologies’, the authors prefer to extract the eventfulness of haphazard and radically uncertain interactions with spirits or wondrous signs apt to be transformed into marvels and rumours. The ethnographies presented in this collection reveal an eventology of spirit worlds and landscape on China’s borderlands, an inquiry that – unlike history – does not study ‘events’ as such but the relation between what is deemed to be an event, a surprise, or a manifestation of wonder and what is deemed to be the innate, natural, ordinary, everyday life.     

Developing Children’s Observation Skills Using a Fractal Pattern from Nature

Abstract

This study aimed to support the development of the scientific observation skills of children at an early age using a pattern selected from nearby nature. For this purpose, a simple, innovative and authentic observation activity was designed using thorny burnet (Sarcopoterium spinosum L.), a plant unique to the Mediterranean region. The activity was conducted in a preschool institution with six-year-old children in the class hours of a weekly science course in three different environments (in-class, out-of-class, and out-of-school), and seven stages. In this activity, which aimed to transform children’s natural/spontaneous observation skills into scientific observation skills, patterns were revealed through systematic and sequential observation and drawings. At the end of the activity, it was found that the children had developed skills related to breaking a whole into its parts and putting the parts together according to patterns, making detailed observations, and systematic data collection, and they successfully implemented these skills outside the classroom and school.     

Wild-ing the Ethnography of Conservation: Writing Nature’s Value and Agency In

When reading ethnographic literature on nature conservation, one may wonder: where has nature gone? Social anthropologists have written nuanced ethnographies of how the environmental projects of governments and transnational NGOs encounter, dispossess, clash culturally with, and try to govern native people across the world. Yet, these diverse ethnographies often say little about what motivates those encounters firstly: local and global nature, especially wildlife, plants, and the planet’s ecological crisis. Thus, this paper seeks ways how ethnographic writing on conservation practice could better reflect that the planet’s many self-willed, struggling, and valued non-humans, too, enter conservation’s encounters. To find paths toward such a ‘wild-ing’ of ethnography, the paper locates and reviews disparate materials from across the social-anthropological literature on biodiversity conservation. The review is structured through three questions: How does and could the ethnography of conservation represent nature’s value? How can it show that animals, plants, and other nature make and meet worlds? How can it incorporate natural science data about non-human worlds and ecological crisis? Altogether, we understand nature conservation clearer through the interdisciplinary and more-than-human ethnography of world-making encounters. Such wilder ethnography may also better connect people’s suffering and nature’s vanishing – as problems both for anthropology and conservation science.     

Nature’s Palette: Characterization of Shared Pigments in Colorful Avian and Mollusk Shells

Pigment-based coloration is a common trait found in a variety of organisms across the tree of life. For example, calcareous avian eggs are natural structures that vary greatly in color, yet just a handful of tetrapyrrole pigment compounds are responsible for generating this myriad of colors. To fully understand the diversity and constraints shaping nature’s palette, it is imperative to characterize the similarities and differences in the types of compounds involved in color production across diverse lineages. Pigment composition was investigated in eggshells of eleven paleognath bird taxa, covering several extinct and extant lineages, and shells of four extant species of mollusks. Birds and mollusks are two distantly related, calcareous shell-building groups, thus characterization of pigments in their calcareous structures would provide insights to whether similar compounds are found in different phyla (Chordata and Mollusca). An ethylenediaminetetraacetic acid (EDTA) extraction protocol was used to analyze the presence and concentration of biliverdin and protoporphyrin, two known and ubiquitous tetrapyrrole avian eggshell pigments, in all avian and molluscan samples. Biliverdin was solely detected in birds, including the colorful eggshells of four tinamou species. In contrast, protoporphyrin was detected in both the eggshells of several avian species and in the shells of all mollusks. These findings support previous hypotheses about the ubiquitous deposition of tetrapyrroles in the eggshells of various bird lineages and provide evidence for its presence also across distantly related animal taxa.     

Plant’s gypsum affinity shapes responses to specific edaphic constraints without limiting responses to other general constraints

Plant and Soil - The root endophyte Phomopsis liquidambaris B3 effectively protected peanut against root rot caused by Fusarium oxysporum. We investigated (i) the effects of preinoculation (before...     

Nature’s care: diarrhea, watershed protection, and biodiversity conservation in Flores, Indonesia

Part of the puzzle surrounding biodiversity loss lies in an incomplete understanding of how humans value the functions and services that flow from biodiversity conservation projects. This paper takes a closer look at the links between the conservation of biodiversity and the livelihoods of rural people who live on the fringes of the parks and protected areas. We revisit some of the key aspects of ecosystem valuation—purpose, methodology, and policy design and implementation—because the links between biodiversity conservation, ecosystem services, and human welfare are obscured by considerable smoke and mirrors. Using a biodiversity conservation project (Ruteng Park) on Flores Island in Indonesia as a case study, we build a concrete empirical example of ecosystem valuation. This conservation project has resulted in spatially patchy watershed protection that allows us to identify and estimate the impacts of watershed services on human health (diarrhea prevalence) in the buffer zone of the park. We conclude by offering a plan of research to improve the design of conservation interventions for protecting biodiversity and providing ecosystem services. These recommendations include developing more conceptual knowledge on the linkages between biodiversity and ecosystem services; scaling up valuation efforts of underappreciated services such as health; shifting focus from valuing services individually to valuing multiple benefits from the same area; and conducting conservation policy experiments to identify causal outcomes (including defensible estimates of ecosystem values).

Eye-tracking women’s preferences for men’s somatotypes

Judging physical attractiveness involves sight, touch, sound and smells. Where visual judgments are concerned, attentional processes may have evolved to prioritize sex-typical traits that reflect cues signaling direct or indirect (i.e. genetic) benefits. Behavioral techniques that measure response times or eye movements provide a powerful test of this assumption by directly assessing how attractiveness influences the deployment of attention. We used eye-tracking to characterize women’s visual attention to men’s back-posed bodies, which varied in overall fat and muscle distribution, while they judged the potential of each model for a short- or long-term relationship. We hypothesized that when judging male bodily attractiveness women would focus more on the upper body musculature of all somatotypes, as it is a signal of metabolic health, immunocompetence and underlying endocrine function. Results showed that mesomorphs (muscular men) received the highest attractiveness ratings, followed by ectomorphs (lean men) and endomorphs (heavily-set men). For eye movements, attention was evenly distributed to the upper and lower back of both ectomorphs and mesomorphs. In contrast, for endomorphs the lower back, including the waist, captured more attention over the viewing period. These patterns in visual attention were evident in the first second of viewing, suggesting that body composition is identified early in viewing and guides attention to body regions that provide salient biological information during judgments of men’s bodily attractiveness.     

Molecular pharming’s foot in the FDA’s door: Protalix’s trailblazing story

Objectives

This short commentary examines the factors that led to Food and Drug Administration’s approval of the first plant-derived biologic.

Results

In 2012, the first plant-derived protein pharmaceutical (biologic) was approved for commercial use in humans. The product, a recombinant form of human β-glucocerebrosidase marketed as ELELYSO, was developed by Protalix Biotherapeutics (Carmiel, Israel). The foresight to select this particular therapeutic product for development, flawless production pipeline, and serendipity seem to provide the key in explaining how ELELYSO became the first plant-derived biologic to achieve approval by Food and Drug Administration.

Conclusions

While the circumstances that enabled Protalix and its scientists to become the first to arrive at this historic milestone are perhaps unique, it is anticipated that more biologics will follow suit in winning regulatory endorsement.