共查询到20条相似文献,搜索用时 31 毫秒
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Sugars as signaling molecules. 总被引:7,自引:0,他引:7
Recent studies indicate that, in a manner similar to classical plant hormones, sugars can act as signaling molecules that control gene expression and developmental processes in plants. Crucial evidence includes uncoupling glucose signaling from its metabolism, identification of glucose sensors, and isolation and characterization of mutants and other regulatory components in plant sugar signal transduction pathways. The emerging scenario points to the existence of a complex signaling network that interconnects transduction pathways from sugars and other hormone and nutrient signals. 相似文献
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Jeong-Ho Kim Adhiraj Roy David Jouandot II Kyu Hong Cho 《Biochimica et Biophysica Acta (BBA)/General Subjects》2013
Background
Most cells possess a sophisticated mechanism for sensing glucose and responding to it appropriately. Glucose sensing and signaling in the budding yeast Saccharomyces cerevisiae represent an important paradigm for understanding how extracellular signals lead to changes in the gene expression program in eukaryotes.Scope of review
This review focuses on the yeast glucose sensing and signaling pathways that operate in a highly regulated and cooperative manner to bring about glucose-induction of HXT gene expression.Major conclusions
The yeast cells possess a family of glucose transporters (HXTs), with different kinetic properties. They employ three major glucose signaling pathways—Rgt2/Snf3, AMPK, and cAMP-PKA—to express only those transporters best suited for the amounts of glucose available. We discuss the current understanding of how these pathways are integrated into a regulatory network to ensure efficient uptake and utilization of glucose.General significance
Elucidating the role of multiple glucose signals and pathways involved in glucose uptake and metabolism in yeast may reveal the molecular basis of glucose homeostasis in humans, especially under pathological conditions, such as hyperglycemia in diabetics and the elevated rate of glycolysis observed in many solid tumors. 相似文献19.
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The roles of MAPKs in disease 总被引:2,自引:0,他引:2
Lawrence MC Jivan A Shao C Duan L Goad D Zaganjor E Osborne J McGlynn K Stippec S Earnest S Chen W Cobb MH 《Cell research》2008,18(4):436-442