共查询到20条相似文献,搜索用时 10 毫秒
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类固醇受体激活物(steroid receptor activator, SRA)是一种 类固醇受体辅激活物.最初的研究认为,SRA只存在RNA形式,不存在蛋白质 形式.但是后来的研究发现,SRA是在RNA和蛋白质两个水平上发挥功能的分 子,其cDNA序列存在687 bp保守的核心区域,该核心区域对其发挥转录共激 活活性是必需的.SRA的RNA形式主要参与核受体的转录共激活作用,其表达 与乳腺癌的发生有很大关系,SRA的蛋白质形式(steroid receptor activator protein ,SRAP)也具有类似的功能.但是不同于RNA形式, SRAP可结合到特定基因的启动子区域,并起到阻遏物的作用.本文对SRA的 特点、表达及功能等方面的最新研究进展及其可能的作用机制与作用形式 进行概述. 相似文献
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Long Non-coding RNAs and Their Biological Roles in Plants 总被引:1,自引:0,他引:1
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Birgit Märtens Salim Manoharadas David Hasenöhrl Andrea Manica Udo Bläsi 《EMBO reports》2013,14(6):527-533
We report the first example of antisense RNA regulation in a hyperthermophilic archaeon. In Sulfolobus solfataricus, the transposon‐derived paralogous RNAs, RNA‐2571–4, show extended complementarity to the 3′ UTR of the 1183 mRNA, encoding a putative phosphate transporter. Phosphate limitation results in decreased RNA‐2571 and increased 1183 mRNA levels. Correspondingly, the 1183 mRNA is faster degraded in vitro upon duplex formation with RNA‐2571. Insertion of the 1183 3′ UTR downstream of the lacS gene results in strongly reduced lacS mRNA levels in transformed cells, indicating that antisense regulation can function in trans. 相似文献
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Irina V. Novikova Scott P. HennellyChang-Shung Tung Karissa Y. Sanbonmatsu 《Journal of molecular biology》2013
Novel, profound and unexpected roles of long non-coding RNAs (lncRNAs) are emerging in critical aspects of gene regulation. Thousands of lncRNAs have been recently discovered in a wide range of mammalian systems, related to development, epigenetics, cancer, brain function and hereditary disease. The structural biology of these lncRNAs presents a brave new RNA world, which may contain a diverse zoo of new architectures and mechanisms. While structural studies of lncRNAs are in their infancy, we describe existing structural data for lncRNAs, as well as crystallographic studies of other RNA machines and their implications for lncRNAs. We also discuss the importance of dynamics in RNA machine mechanism. Determining commonalities between lncRNA systems will help elucidate the evolution and mechanistic role of lncRNAs in disease, creating a structural framework necessary to pursue lncRNA-based therapeutics. 相似文献
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Selective termination of lncRNA transcription promotes heterochromatin silencing and cell differentiation 下载免费PDF全文
Leila Touat‐Todeschini Nicolas Thierry‐Mieg Benoit Gilquin Edwige Hiriart Ravi Sachidanandam Emeline Lambert Janine Brettschneider Michael Reuter Jan Kadlec Ramesh Pillai Akira Yamashita Masayuki Yamamoto André Verdel 《The EMBO journal》2017,36(17):2626-2641
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Concerted regulation of mitochondrial and nuclear non‐coding RNAs by a dual‐targeted RNase Z 下载免费PDF全文
Stefan J Siira Giulia Rossetti Tara R Richman Kara Perks Judith A Ermer Irina Kuznetsova Laetitia Hughes Anne‐Marie J Shearwood Helena M Viola Livia C Hool Oliver Rackham Aleksandra Filipovska 《EMBO reports》2018,19(10)