共查询到20条相似文献，搜索用时 570 毫秒
1.
Background
Molecular maps have been developed for many species, and are of particular importance for varietal development and comparative genomics. However, despite the existence of multiple sets of linkage maps, databases of these data are lacking for many species, including peanut. 相似文献2.
Background
There exist many segmentation techniques for genomic sequences, and the segmentations can also be based on many different biological features. We show how to evaluate and compare the quality of segmentations obtained by different techniques and alternative biological features. 相似文献3.
Vance L Trudeau Gustavo M Somoza Guillermo S Natale Bruce Pauli Jacqui Wignall Paula Jackman Ken Doe Fredrick W Schueler 《Reproductive biology and endocrinology : RB&E》2010,8(1):36
Background
It is well known that many anurans do not reproduce easily in captivity. Some methods are based on administration of mammalian hormones such as human chorionic gonadotropin, which are not effective in many frogs. There is a need for simple, cost-effective alternative techniques to induce spawning. 相似文献4.
5.
Allisan Aquilina-Beck Kristine Ilagan Qin Liu Jennifer O Liang 《BMC developmental biology》2007,7(1):126
Background
Nodals are secreted signaling proteins with many roles in vertebrate development. Here, we identify a new role for Nodal signaling in regulating closure of the rostral neural tube of zebrafish. 相似文献6.
7.
Tiago Antao Ana Lopes Ricardo J Lopes Albano Beja-Pereira Gordon Luikart 《BMC bioinformatics》2008,9(1):323
Background
Testing for selection is becoming one of the most important steps in the analysis of multilocus population genetics data sets. Existing applications are difficult to use, leaving many non-trivial, error-prone tasks to the user. 相似文献8.
Background
Accurate classification of microarray data is critical for successful clinical diagnosis and treatment. The "curse of dimensionality" problem and noise in the data, however, undermines the performance of many algorithms. 相似文献9.
Background
The hypothesis of immunosurveillance suggests that new neoplasms arise very frequently, but most are destroyed almost at their inception by an immune response. Its correctness has been debated for many years. 相似文献10.
Luke S Tain Encarnación Lozano Alberto G Sáez Armand M Leroi 《BMC developmental biology》2008,8(1):28
Background
Dietary restriction (DR) results in increased longevity, reduced fecundity and reduced growth in many organisms. Though many studies have examined the effects of DR on longevity and fecundity, few have investigated the effects on growth. 相似文献11.
Panagiotis Agouridakis Despina Kyriakou Michael G Alexandrakis Athanasios Prekates Kostas Perisinakis Nikolaos Karkavitsas Demosthenes Bouros 《Respiratory research》2002,3(1):25
Background
The predictive role of many cytokines and adhesion molecules has not been studied systematically in acute respiratory distress syndrome (ARDS). 相似文献12.
Shaw-Wei D Tsen Chao-Yi Wu Avedis Meneshian Sara I Pai Chien-Fu Hung T-C Wu 《Journal of biomedical science》2009,16(1):36-7
Background
Gene therapy with plasmid DNA is emerging as a promising strategy for the treatment of many diseases. One of the major obstacles to such therapy is the poor transfection efficiency of DNA in vivo. 相似文献13.
Luke C Henry Sébastien Tremblay Suzanne Leclerc Abdesselam Khiat Yvan Boulanger Dave Ellemberg Maryse Lassonde 《BMC neurology》2011,11(1):105
Background
Despite negative neuroimaging findings many athletes display neurophysiological alterations and post-concussion symptoms that may be attributable to neurometabolic alterations. 相似文献14.
Background
Knowledge-based potentials have been widely used in the last 20 years for fold recognition, protein structure prediction from amino acid sequence, ligand binding, protein design, and many other purposes. However generally these are not readily accessible online. 相似文献15.
Background
Introducing point mutations into bacterial chromosomes is important for further progress in studies relying on functional genomics, systems- and synthetic biology, and for metabolic engineering. For many investigations, chromosomal systems are required rather than artificial plasmid based systems. 相似文献16.
Zhijun Wang Li Xiang Junjie Shao Alicja Węgrzyn Grzegorz Węgrzyn 《Microbial cell factories》2006,5(1):34-18
Background
Although understanding of physiological interactions between plasmid DNA and its host is important for vector design and host optimization in many biotechnological applications, to our knowledge, global studies on plasmid-host interactions have not been performed to date even for well-characterized plasmids. 相似文献17.
Background
Molecular recognition between enzymes and proteic inhibitors is crucial for normal functioning of many biological pathways. Mutations in either the enzyme or the inhibitor protein often lead to a modulation of the binding affinity with no major alterations in the 3D structure of the complex. 相似文献18.
Zasha Weinberg Joy X Wang Jarrod Bogue Jingying Yang Keith Corbino Ryan H Moy Ronald R Breaker 《Genome biology》2010,11(3):R31
Background
Structured noncoding RNAs perform many functions that are essential for protein synthesis, RNA processing, and gene regulation. Structured RNAs can be detected by comparative genomics, in which homologous sequences are identified and inspected for mutations that conserve RNA secondary structure. 相似文献19.
