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Klaus Stark Jozef Rovenský Stanislava Blažičková Hans Grosse-Wilde Stanislav Ferencik Christian Hengstenberg Rainer H Straub 《Arthritis research & therapy》2009,11(3):R70-10
Introduction
Both genetic and environmental factors contribute to rheumatoid arthritis (RA), a common and complex autoimmune disease. As well as the major susceptibility gene HLA-DRB1, recent genome-wide and candidate-gene studies reported additional evidence for association of single nucleotide polymorphism (SNP) markers in the PTPN22, STAT4, OLIG3/TNFAIP3 and TRAF1/C5 loci with RA. This study was initiated to investigate the association between defined genetic markers and RA in a Slovak population. In contrast to recent studies, we included intensively-characterized osteoarthritis (OA) patients as controls. 相似文献9.
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