共查询到20条相似文献,搜索用时 31 毫秒
1.
Navratna Vajpai André Strauss Gabriele Fendrich Sandra W. Cowan-Jacob Paul W. Manley Wolfgang Jahnke Stephan Grzesiek 《Biomolecular NMR assignments》2008,2(1):41-42
Imatinib (Glivec or Gleevec) potently inhibits the tyrosine kinase activity of BCR-ABL, a constitutively activated kinase,
which causes chronic myelogenous leukemia (CML). Here we report the first almost complete backbone assignment of c-ABL kinase
domain in complex with imatinib.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users. 相似文献
2.
We have obtained the first momentary photographs of sperms just as they are discharged from the antheridium of a liverwort,
Conocephalum conicum, and have succeeded in monitoring the airborne sperms of bryophytes under field conditions. Airborne sperm of liverworts
seems to be an effective strategy for raising the efficiency of fertilization between male and female plants separated in
a drought environment.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users. 相似文献
3.
Luis H. Gutiérrez-González Lucia Muresanu Luis del Pozo-Yauner Rosalba Sánchez Leopoldo Guereca Baltazar Becerril Christian Lücke 《Biomolecular NMR assignments》2007,1(2):159-161
An allotypic variation at position 25 influences the fibrillogenicity of λVI light chains, which are related to humoral immune
response and have been associated with AL amyloidosis. The full resonance assignment and a preliminary structural characterization
of 6aJL2(R25G) are reported.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users. 相似文献
4.
Stewart JJ 《Journal of molecular modeling》2004,10(1):6-12
A comparison is made of the relative accuracy of some NDDO semiempirical methods and the DFT functionals LYP and PW91 using both double and triple zeta basis sets. The comparison is between the calculated heat of formation and that reported in the NIST database.Electronic Supplementary Material Parameters for the tailored method are available in the supplementary material; these are suitable for use with MOPAC2002. All raw data (experimental heats of formation, geometries, total energies and heats of formation for the various methods, etc.) are also provided in CAChe format. Supplementary material is available for this article if you access the article at . A link in the frame on the left on that page takes you directly to the supplementary material. 相似文献
5.
Philippe S. Nadaud Jonathan J. Helmus Christopher P. Jaroniec 《Biomolecular NMR assignments》2007,1(1):117-120
Complete 13C and 15N assignments of the B3 IgG-binding domain of protein G (GB3) in the microcrystalline solid phase, obtained using 2D and 3D
MAS NMR, are presented. The chemical shifts are used to predict the protein backbone conformation and compared with solution-state
shifts.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users. 相似文献
6.
Prokaryotic lifestyles in deep sea habitats 总被引:1,自引:0,他引:1
Gradients of physicochemical factors influence the growth and survival of life in deep-sea environments. Insights into the
characteristics of deep marine prokaryotes has greatly benefited from recent progress in whole genome and metagenome sequence
analyses. Here we review the current state-of-the-art of deep-sea microbial genomics. Ongoing and future genome-enabled studies
will allow for a better understanding of deep-sea evolution, physiology, biochemistry, community structure and nutrient cycling.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users.
An erratum to this article can be found at 相似文献
7.
This paper presents a new Fiedler vector model for categorising amino acids, which is based on the Miyazawa-Jernigan matrix.
The model splits the amino acid residues into two hydrophobic groups (LFI) and (MVWCY) and two polar groups (HATGP) and (RQSNEDK).
In so doing, it independently confirms the findings of Wang and Wang and Cieplak et al. and demonstrates the validity of using
eigenvectors to partition amino acid groups.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users. 相似文献
8.
Tardigrada is a phylum closely allied with the arthropods. They are usually less than 0.5 mm in length, have four pairs of
lobe-like legs and are either carnivorous or feed on plant material. Most of the 900+ described tardigrade species are limnoterrestrial
and live in the thin film of water on the surface of moss, lichens, algae, and other plants and depend on water to remain
active and complete their life cycle. In this review of 910 tardigrade species, only 62 species representing13 genera are
truly aquatic and not found in limnoterrestrial habitats although many other genera contain limnoterrestrial species occasionally
found in freshwater.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users. 相似文献
9.
In this report we generated mice co-transgenic for a minimal promoter LacZ construct and a mouse BAC from the gene poor region
upstream of the Hoxd cluster. In addition to expression in the distal limb, genital bud, and spinal cord, we show that this BAC transgene also
reproducibly drives unique bilateral, dorsal posterior commissure expression. The ability of this BAC to direct posterior
commissure expression makes it worthy of further study as a valuable tool in transgenic/targeting experiments.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users. 相似文献
10.
Jan Marchant Kovilen Sawmynaden Savvas Saouros Peter Simpson Stephen Matthews 《Biomolecular NMR assignments》2008,2(2):119-121
Microneme protein 4 is involved in cell binding by the important parasite Toxoplasma gondii. We present here the backbone and side-chain assignments of the first two apple domains together with a new graphical aid
for their assignment using NMRView.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users. 相似文献
11.
Lipocalin2 plays an important role in the innate immune system. In this article we report the backbone and side-chain resonance
assignments of rat lipocalin2 (rLcn2). These assignments provide a basis for determining the structure and dynamics of rLcn2.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users. 相似文献
12.
Savvas Saouros Kovilen Sawmynaden Jan Marchant Peter Simpson Stephen Matthews 《Biomolecular NMR assignments》2008,2(2):175-177
Microneme protein complexes are important for invasion of host cells by Toxoplasma gondii. We report the resonance assignment of the galectin-like domain of microneme protein 1 in complexes with the second and third
EGF domains from microneme protein 6.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users. 相似文献
13.
Belén Fernández Natividad Gálvez Purificación Sánchez Rafael Cuesta Ruperto Bermejo José M. Domínguez-Vera 《Journal of biological inorganic chemistry》2008,13(3):349-355
We simultaneously labeled ferritin with two Alexa Fluor fluorophores (AF350 and AF430). When both fluorophores label the same
ferritin subunit, fluorescence resonance energy transfer (FRET) takes place from the excited AF350 to the acceptor AF430.
By varying the number and the ratio of labeling fluorophores, we can modulate FRET such that the ferritin particles can exhibit
multiple colors under UV illumination. Labeling of the ferritin shell does not affect the properties of the metallic core.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users. 相似文献
14.
Coordinated international action to accelerate genome-to-phenome with FAANG,the Functional Annotation of Animal Genomes project 总被引:1,自引:0,他引:1
《Genome biology》2015,16(1)
We describe the organization of a nascent international effort, the Functional Annotation of Animal Genomes (FAANG) project, whose aim is to produce comprehensive maps of functional elements in the genomes of domesticated animal species.
Electronic supplementary material
The online version of this article (doi:10.1186/s13059-015-0622-4) contains supplementary material, which is available to authorized users. 相似文献15.
High amino acid coverage labeling of the mammalian G protein coupled receptors (GPCR) rhodopsin was established with 15N and 15N/13C isotopes. Rhodopsin was expressed at preparative scale in HEK293S cells and studied in full-length by NMR spectroscopy in
detergent micelle solution. This resulted in the assignment and detailed study of the dynamic properties of the C-terminus
of rhodopsin. The rhodopsin C-terminus is immobilized until Ala333, after which it becomes unstructured.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users. 相似文献
16.
Many faces of drebrin: from building dendritic spines and stabilizing gap junctions to shaping neurite-like cell processes 总被引:2,自引:2,他引:0
In this review we consider the multiple functions of developmentally regulated brain protein (drebrin), an actin-binding protein,
in the formation of cellular polarity in different cell types. Drebrin has a well-established role in the morphogenesis, patterning
and maintenance of dendritic spines in neurons. We have recently shown that drebrin also stabilizes Connexin-43 containing
gap junctions at the plasma membrane. The latest literature and our own data suggest that drebrin may be broadly involved
in shaping cell processes and in the formation of stabilized plasma membrane domains, an effect that is likely to be of crucial
significance for formation of cell polarity in both neuronal and non-neuronal types.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users. 相似文献
17.
Sarah D Kocher Cai Li Wei Yang Hao Tan Soojin V Yi Xingyu Yang Hopi E Hoekstra Guojie Zhang Naomi E Pierce Douglas W Yu 《Genome biology》2015,16(1)
During the type-setting of the final version of the article [1] some of the additional files were swapped, and several were completely replaced. The correct files are republished in this Erratum.
Electronic supplementary material
The online version of this article (doi:10.1186/s13059-014-0574-0) contains supplementary material, which is available to authorized users. 相似文献18.
A small percentage of Orthoptera Acridomorpha is comprised species dependant on continental water ecosystems. However, as
phytophagous insects, they are important at the basis of the trophic chain, mainly in regions with large permanent biota resulting
from the pulses of the rivers. An assessment of the composition and origin of the populations from different biogeographical
regions is attempted, and the state of our current knowledge is given in Tables 1, 2 and 3.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users.
Guest editors: E. V. Balian, C. Lévêque, H. Segers & K. Martens
Freshwater Animal Diversity Assessment 相似文献
19.
Ludwig A Heimbucher T Gregor W Czerny T Schmetterer G 《Applied microbiology and biotechnology》2008,78(4):729-735
The unicellular cyanobacterium Synechocystis sp. PCC6714 can grow not only under photoautotrophic conditions, but also under chemoheterotrophic conditions if glucose
is added to the medium. This makes it useful for the study of many aspects of bioenergetic mechanisms. In contrast to its
closely related strain Synechocystis sp. PCC6803, which cannot grow chemoheterotrophically, Synechocystis PCC6714 is not naturally transformable. To enable gene transfer in this strain, we established a method for the introduction
of self-replicating IncQ plasmids and for gene replacement using electroporation.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users. 相似文献
20.
Springs are important freshwater habitats that provide refuge for many rare species. In this study, the fauna and abiotic
parameters of 20 perennial springs in north-western Switzerland were investigated. Correlation of abiotic and macrozoobenthos
data showed that physicochemical parameters had little impact on macrozoobenthic composition, whereas specific substrate parameters
strongly influenced the composition of the macrofauna. Surprisingly, nonmetric multidimensional scaling did not reveal a grouping
of springs with similar substrate composition or macrozoobenthic assemblages. However, discharge was identified as the factor
significantly determining substrate and the composition of macroinvertebrate assemblages. This justifies the hypothesis that,
variation in discharge is the disturbance factor governing the macrofaunal composition temporally and spatially within and
between patches.
Electronic supplementary material Electronic supplementary material is available for this article at
and accessible for authorised users. 相似文献