共查询到20条相似文献,搜索用时 140 毫秒
1.
2.
Cloning and Characterization of Two Evolutionarily Conserved Subunits (TFIIIC102 and TFIIIC63) of Human TFIIIC and Their Involvement in Functional Interactions with TFIIIB and RNA Polymerase III 下载免费PDF全文
Yng-Ju Hsieh Zhengxin Wang Robert Kovelman Robert G. Roeder 《Molecular and cellular biology》1999,19(7):4944-4952
3.
4.
5.
6.
7.
8.
9.
10.
11.
12.
Wei Z Zhang P Zhou Z Cheng Z Wan M Gong W 《The Journal of biological chemistry》2004,279(33):34983-34990
eIF3k, the smallest subunit of eukaryotic initiation factor 3 (eIF3), interacts with several other subunits of eIF3 and the 40 S ribosomal subunit. eIF3k is conserved among high eukaryotes, including mammals, insects, and plants, and it is ubiquitously expressed in human tissues. Interestingly, eIF3k does not exist in some species of yeast. Thus, eIF3k may play a unique regulatory role in higher organisms. Here we report the crystal structure of human eIF3k, the first high-resolution structure of an eIF3 component. This novel structure contains two distinct domains, a HEAT (named for Huntington, elongation factor 3, A subunit of protein phosphatase 2A, target of rapamycin) repeat-like HAM (HEAT analogous motif) domain and a winged-helix-like WH domain. Through structural comparison and sequence conservation analysis, we show that eIF3k has three putative protein-binding surfaces and has potential RNA binding activity. The structure provides key information for understanding the structure and function of the eIF3 complex. 相似文献
13.
14.
15.
16.
17.
18.
19.
20.