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1.
Highlights? CLV1 receptor kinase regulates stemness in Arabidopsis root and shoot meristems ? CLV1 and ACR4 form homo- and heteromeric complexes as shown by a novel FRET assay ? CLV1/ACR4 complexes differ in composition between plasma membrane and plasmodesmata ? CLV1/ACR4 complexes regulate distal root meristem maintenance  相似文献   

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Highlights? Overview of recent progress in the structural characterization of eukaryotic ribosomes and initiation complexes. ? Crystal structures, cryo-EM and biochemical data are combined to derive structural models of larger assemblies. ? Homology models of eukaryotic initiation complexes provide a starting point for future experiments.  相似文献   

3.
Highlights? Polypeptide fragment interaction patterns predict bound protein-peptide complexes ? Peptide structures can be refined or extended by polypeptide fragment alphabets ? Interacting polypeptide fragment pairs guide domain-domain interface identification ? Interacting polypeptide fragment scaffolds have potential to dock protein domains  相似文献   

4.
Highlights? FOXO forms redox-sensitive, disulfide-dependent complexes with several proteins ? Transportin-1 binds to FOXO via a disulfide and regulates its nuclear localization ? Redox and insulin signaling govern FOXO nuclear localization via distinct pathways ? Redox control of longevity protein FOXO/DAF-16 is evolutionarily conserved  相似文献   

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Highlights? The AvGluR1 LBD is a hybrid structure with iGluR prokaryotic and eukaryotic features ? AvGluR1 binds hydrophobic amino acids as well as glutamate ? Chloride ions acts as surrogate ligand atoms in the Ala, Ser, and Met complexes ? The AvGluR1 LBD assembles as a dimer but with very low affinity  相似文献   

7.
Highlights? Different Vps34 complexes are distinctly regulated upon energy stress ? AMPK activates the proautophagy Vps34 complex by phosphorylating Beclin1 ? AMPK inhibits the nonautophagic Vps34 complex by phosphorylating Vps34 ? ATG14L determines whether the Vps34 complex is activated or inhibited by AMPK  相似文献   

8.
Highlights? The crystal structure of the heterotetrameric CRL3-SPOP ubiquitin ligase is reported ? Substrate adaptor proteins are recruited to CRL complexes through a signature motif ? Tandem BTB and BACK domains potentiate assembly and activity of the CRL3-SPOP ligase ? The SPOPL negative regulator creates a molecular rheostat to fine-tune CRL3 activity  相似文献   

9.
Highlights? Escherichia coli: a highly versatile host to produce samples for structural biology. ? High-throughput technologies have increased single protein expression success rates. ? Co-expression eases production of complexes but still suffers from bottlenecks. ? Co-expression combined with high-throughput can tackle complex assemblies.  相似文献   

10.
Highlights? Piwi-piRNA complexes bind to numerous piRNA-complementary sequences in the genome ? piRNA is necessary and sufficient to recruit Piwi, HP1, and HMT to its target site ? Piwi deficiency drastically changes the epigenetic landscape in the genome ? The Piwi-piRNA mechanism is a major epigenetic programming mechanism in Drosophila  相似文献   

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Highlights? Smad-interacting protein 1 (SIP1) regulates hESC differentiation ? SIP1 upregulation promotes neuroectodermal differentiation ? SIP1 inhibits mesendodermal and endodermal differentiation ? SMAD2/3 and NANOG/OCT4/SOX2 cooperatively regulate SIP1 expression  相似文献   

14.
Highlights? AtBMI1A/B proteins prevent misexpression of embryonic traits in somatic cells ? PRC2 and AtBMI1A/B proteins maintain cells in their differentiated state ? AtBMI1A/B proteins mediate H2A monoubiquitination  相似文献   

15.
Highlights? Perivascular niche nitric oxide activates Notch in PDGF-induced gliomas ? Notch signaling drives tumor stem-like characteristics and reduces survival ? Loss of eNOS activity decreases tumor stem-like characteristics ? Suppressing eNOS activity prolongs survival in glioma-bearing mice  相似文献   

16.
Highlights? Genome-wide single-nucleotide resolution methylation maps in 86 silencing mutants ? Complex interplays between different DNA methylation pathways ? Identification of novel regulators of DNA methylation  相似文献   

17.
Highlights? Individual mutant phenotypes in a saturation library derived via deep sequencing ? Residue depth and active-site residue derivation from mutant phenotypes ? Mutant-phenotype-derived parameters used for protein model discrimination ? Derivation of sequence-structure-function relationships without protein isolation  相似文献   

18.
Highlights? Drosophila Matrix Metalloprotease (Mmp) inhibits FGF signaling ? An FGF – MMP feedback loop regulates branching morphogenesis ? Mmp2 spatially regulates FGF signaling in epithelia  相似文献   

19.
Highlights? Unflipped AP site stabilized by helix-hairpin-helix DNA glycosylase homolog Mag2 ? Nonenzymatic AP site recognition and DNA sculpting ? Sculpting of DNA conformation enhances substrate transfer between proteins  相似文献   

20.
Highlights? Missing domains in PFV intasome revealed by SAXS/SANS ? PFV IN undergoes dramatic changes in conformation and oligomerization upon binding DNA ? Strand transfer inhibitors do not alter quaternary structure of PFV intasome  相似文献   

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