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1.
Six alkaloids have been isolated from the leaves of Glycosmis bilocularis, 5 of which are known compounds viz. arborine, arborinine, glycorine, kokusaginine and skimmianine, all previously isolated from other species of Glycosmis. The sixth alkaloid was identified as 1,5-dihydroxy-2,3-dimethoxy-10-methyl-9-acridone (5-hydroxy-arborinine). 相似文献
2.
From the unripe seeds of Cassia torosa three new dimeric hydroanthracene derivatives were isolated along with stigmasterol, sitosterol, campesterol, physcion-9-anthrone, torosachyrsone and the phlegmacins A2 and B2. The structures of the new derivatives were established as physcion-10, 10′-bianthrone, anhydrophlegmacin B2 [2-(6′-methoxy-3′-methyl-3′, 8′, 9′-trihydroxy-1′-oxo-1′, 2′, 3′, 4′-tetrahydroanthracene-10′-yl)-1, 8-dihydroxy-3-methoxy-6-methyl-9-oxo-9, 10-dihydroanthracene] and torosanin [2-(6′-methoxy-3′-methyl-3′, 8′,9′-trihydroxy-1′-oxo-1′, 2′, 3′,4′-tetrahydroanthracene-5′-yl)-1, 8-dihydroxy-3-methoxy-6-methyl-9-oxo-9, 10-dihydroanthracene], respectively. 相似文献
3.
《Phytochemistry》1986,25(12):2889-2891
An investigation of Schizogyne glaberrima afforded in addition to known compounds 3-(acetoxy-methyl)-6-methyl-5-methoxy-benzofuran,10-acctoxy-8,9-epoxy-6-methoxy-thymol isobutyrate, 10-acetoxy-8-hydroxy-9-isobutyryloxy-6-methoxy-thymol,8-hydroxy-9,10-isobutyryloxy-thymol and 8,10-dihydroxy-9-isobutyryloxy-thymol, five new thymol derivatives, 8-ethoxy-9-isobutyryloxy-thymol, 10-acetoxy-8,9-dehydro-6-methoxy-thymol isobutyrate, 6-acetoxy-8,9-dehydro-9-carbomethoxy-10-hydroxy-thymol and 8,9-dihydroxy-10-isobutyryloxy-6-methoxy-thymol. 相似文献
4.
A sensitive fluorescent method is described for the detection of 4′-(9-acridinylamino)-methanesulfon-m-anisidide (AMSA) in serum. The assay is based on the alkaline hydrolysis of AMSA into 9(10H)-acridone. While AMSA has negligible fluorescence, 9(10H)-acridone fluoresces brilliantly (excitation 266 nm, emission 470 nm). The assay is shown to be linear from 0.01 to 1.0 μm. In addition, the assay is shown to be useful, in conjunction with an ethyl acetate extraction, in distinguishing serum levels of parent AMSA from metabolized or protein-bound AMSA. 相似文献
5.
Oxanthrone esters from the aerial parts of Cassia kleinii 总被引:1,自引:0,他引:1
From the aerial parts of Cassia kleinii two new oxanthrone esters, kleinioxanthrone-1 and kleinioxanthrone-2 have been isolated. Their structures were established as 1,8-dihydroxy-3-methyl-6-methoxy-9(10H)-anthracenone-10-oxydecanoate 1 and 1,8-dihydroxy-3-methyl-9(10H)-anthracenone-10-oxytetradecanoate 2 respectively based on degradative and spectroscopic evidence. 相似文献
6.
Rostand M. Ngoumfo Jean-Bosco Jouda Ferdinand T. Mouafo Justin Komguem Céline D. Mbazoa Tze Chieh Shiao Mohammed I. Choudhary Hartmut Laatsch Jean Legault André Pichette René Roy 《Bioorganic & medicinal chemistry》2010,18(10):3601-3605
Chemical investigation of the roots and fruits of Zanthoxylum leprieurii Guill. et Perr. led to the isolation of three new alkaloids including two acridone derivatives, 3-hydroxy-1,4-dimethoxy-10-methyl-9-acridone (2) and 3-hydroxy-1,2-dimethoxy-10-methyl-9-acridone (3) named helebelicine A and B, respectively, and one secobenzo[c]phenantridine, 10-O-demethyl-12-O-methylarnottianamide (10), together with thirteen other compounds. The structures of compounds 2, 3 and 10 as well as those of the known compounds were elucidated by using spectroscopic methods and by comparison with reported data. The brine-shrimp (artemia salina) lethality bioassay of the chloroform extract of the fruits showed modest cytotoxicity with LD50 at 13.1 μg/mL. Isolated compounds 1, 4–6 were found to be moderately active against lung carcinoma cells (A549), colorectal adenocarcinoma cells (DLD-1) and normal cells (WS1) with IC50 values ranging from 27 to 77 μM. In contrast to the positive control etoposide used, the cytotoxicity of the most active compound 4 was found to be selective against cancer cells in comparison to normal cells WS1 with IC50 of 51 ± 8 μM and 4.3 ± 0.4 μM, respectively. 相似文献
7.
《Biochemical Systematics and Ecology》2005,33(10):1049-1059
Five unusual C-methylflavonoids lacking B-ring oxygenation (2′,4′-dihydroxy-3′,5′-dimethyl-6′-methoxychalcone, 2′,4′-dihydroxy-3′-methyl-6′-methoxychalcone, 2′,6′-dihydroxy-3′-methyl-4′-methoxychalcone, 2′-hydroxy-3′-methyl-4′,6′-dimethoxychalcone and 5,7-dihydroxy-6,8-dimethylflavanone) were found for the first time in Metrosideros excelsa. The flavanone was the major constituent in leaves, whereas 2′,6′-dihydroxy-3′-methyl-4′-methoxychalcone dominated all other aerial plant parts studied. Other Metrosideros species were investigated for these five flavonoids. C19–C36 aldehydes and C22–C32 alcohols were also identified from the dried seed capsules of M. excelsa. 相似文献
8.
《Phytochemistry》1998,49(6):1585-1587
The C-1′ epimers of the sesquiterpenoids 2-(1′,2′-dihydroxy-1′-methylethyl)-6,10-dimethylspiro[4,5]dec-6,9-dien-8-one and 2-(1′,2′-dihydroxy-1′-methylethyl)-6,10-dimethyl-9-hydroxyspiro[4,5]dec-6-en-8-one were isolated from potato tubers infected with Phoma foveata and Fusarium spp., in addition to 4,4a,5,6,7-hexahydro-3-hydroxy-6-(1′,2′-dihydroxy-1′-methylethyl)-4-methyl-2(3H)-naphthalenone, N-trans-p-coumaroyl tyramine and N-trans-feruloyl tyramine. Three of the compounds are novel. 相似文献
9.
Chemical studies on the constituents of Eranthis cilicica led to isolation of ten chromone derivatives, two of which were previously known. Comprehensive spectroscopic analysis, including extensive 1D and 2D NMR data, and the results of enzymatic hydrolysis allowed the chemical structures of the compounds to be assigned as 8,11-dihydro-5-hydroxy-2,9-dihydroxymethyl-4H-pyrano[2,3-g][1]benzoxepin-4-one, 5,7-dihydroxy-8-[(2E)-4-hydroxy-3-methylbut-2-enyl]-2-methyl-4H-1-benzopyran-4-one, 5,7-dihydroxy-2-hydroxymethyl-8-[(2E)-4-hydroxy-3-methylbut-2-enyl]-4H-1-benzopyran-4-one, 7-[(β-d-glucopyranosyl)oxy]-5-hydroxy-8-[(2E)-4-hydroxy-3-methylbut-2-enyl]-2-methyl-4H-1-benzopyran-4-one, 7-[(β-d-glucopyranosyl)oxy]-5-hydroxy-2-hydroxymethyl-8-[(2E)-4-hydroxy-3-methylbut-2-enyl]-4H-1-benzopyran-4-one, 9-[(O-β-d-glucopyranosyl-(1→6)-β-d-glucopyranosyl)oxy]methyl-8,11-dihydro-5,9-dihydroxy-2-methyl-4H-pyrano[2,3-g][1]benzoxepin-4-one, 8,11-dihydro-5,9-dihydroxy-9-hydroxymethyl-2-methyl-4H-pyrano[2,3-g][1]benzoxepin-4-one, and 7-[(O-β-d-glucopyranosyl-(1→6)-β-d-glucopyranosyl)oxy]methyl-4-hydroxy-5H-furo[3,2-g][1]benzopyran-5-one, respectively. The isolated compounds were evaluated for their antioxidant activity. 相似文献
10.
Oxanthrone esters from the roots of Cassia kleinii 总被引:1,自引:0,他引:1
From the roots of Cassia kleinii two new oxanthrone esters, kleinioxanthrone-3 and kleinioxanthrone-4 have been isolated. Their structures were established as 1,8-dihydroxy-3-methyl-9(10H)-anthracenone-10-oxyhexadecanoate 3 and 2,6,7-trihydroxy-1,8-dimethoxy-3-methyl-9(10H)-anthracenone-10-oxydecanoate 4 respectively based on degradative and spectroscopic evidence. 相似文献
11.
Astréa M. Giesbrecht Nídia C. Franca Otto R. Gottlieb Arnaldo I. Da Rocha 《Phytochemistry》1974,13(10):2285-2293
The trunk wood of Licaria canella contains, besides dillapiol and elemicin, the neolignans canellin-A, -B and -C, for which the respective structures of 1-allyl-4,8-dihydroxy-3,5-dimethoxy-7-methyl-6-piperonylbicyclo-[3,2,1]octane; 3a-allyl-4,5-dimethoxy-3-methyl-2-piperonyl-2,3,3a,6,7,7a-hexahydro-6-oxobenzofuran and 1-allyl-4,8-dihydroxy-5-methoxy-7-methyl-6-piperonyl-3-oxobicyclo-[3,2,1] octane are proposed. 相似文献
12.
A new cadalane type sesquiterpenoid, 1, 6-dihydroxy-3-methyl-5-(1-methylethyl)-7-methoxy-8-carboxylic acid (8 → 1 lactone) has been isolated from a 50% aqueous methanolic extract of 6–9 months old cultivated roots of Salmalia malbarica (Bombax malbaricum). 相似文献
13.
Koshi Saito Hamako Obata-Sasamoto Shin-Ichi Hatanaka Hiroshi Noguchi Ushio Sankawa Atsushi Komamine 《Phytochemistry》1982,21(2):474-476
Isolation and identification of l-3-carboxy-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline and l-1-methyl-3-carboxy-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline from seeds and callus of S. hassjoo are described. Administration of [β-14C]-labelled DOPA to a callus culture of this legume resulted in the incorporation of radioactivity into l-3-carboxy-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, l-1-methyl-3-carboxy-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline and stizolobic acid, which was confirmed by constant specific radioactivity after co-crystallization with authentic samples of each compound. 相似文献
14.
From the extract of the fruits of Solanum xanthocarpum (Solanaceae), five new steroidal compounds were isolated and characterized: 4α-methyl-24ξ-ethyl-5α-cholest-7-en-3β,22ξ-diol (1), 3β,22ξ-dihydroxy-4α-methyl-24ξ-ethyl-5α-cholest-7-en-6-one (2), 3β-benzoxy-14β,22ξ-dihydroxy-4α-methyl-24ξ-ethyl-5α-cholest-7-en-6-one (3), 3β-benzoxy-14α,22ξ-dihydroxy-4α-methyl-24ξ-ethyl-5α-cholest-7-en-6-one (4) and 3β-(p-hydroxy)-benzoxy-22ξ-hydroxy-4α-methyl-24ξ-ethyl-5α-cholest-7-en-6-one (5). 相似文献
15.
The structure of canarione, a new naphthoquinone from the lichens Usnea canariensis and U. hookeri was elucidated by UV, 1H-NMR, 13C-NMR, mass spectrometry, and chemical degradation as 5,8-dihydroxy-2-methyl-4H-naphtho [2,3b]-pyran-4,6,9 (6H, 9H)- trione. 相似文献
16.
Manning K Petrunak E Lebo M González-Sarrías A Seeram NP Henry GE 《Phytochemistry》2011,72(7):662-667
An acylphloroglucinol, elliptophenone A, and two xanthones, elliptoxanthone A and elliptoxanthone B, were isolated from the aerial portions of Hypericum ellipticum together with three known xanthones, 1,3,7-trihydroxy-8-(3-methyl-2-butenyl)-9H-xanthen-9-one, 1,6-dihydroxy-4-methoxy-9H-xanthen-9-one, and 1,4,5-trihydroxy-9H-xanthen-9-one. Their structures were determined by spectroscopic analyses. The acylphloroglucinol and xanthones were evaluated for cytotoxicity using three human colon cancer cell lines cell lines (HT-29, HCT-116 and Caco-2) and a normal human colon cell line (CCD-18Co). 相似文献
17.
Two new anthraquinones have been isolated from the root bark of Cassia sophera and characterized as 1,8-dihydroxy-3,6-dimethoxy-2-methyl-7-vinylanthraquinone and 1,3-dihydroxy-5,7,8-trimethoxy-2-methylanthraquinone. 相似文献
18.
Five oxanthrone C-glycosides, namely rumejaposide A-E, and an epoxynaphthoquinol, together with eight known compounds, 2,6-dihydroxy benzoic acid, 4-hydroxy benzoic acid, epicatechin, 4-hydroxy-3-methoxy benzoic acid, 2,6-dimethoxy-4-hydroxyl benzoic acid, rutin, emodin and 2-acetyl-1,8-dihydroxy-3-methyl-6-methoxynaphthalene, were isolated from the roots of Rumex japonicus. The structures of the oxanthrone C-glycosides were elucidated by application of spectroscopic methods as (10R)10-C-beta-glucopyranosyl-1,8,10-trihydroxy-2-carboxyl-3-methyl-9(10H)-anthracenone, (10S)10-C-beta-glucopyranosyl-1,8,10-trihydroxy-2-carboxyl-3-methyl-9(10H)-anthracenone, (10R)10-C-beta-glucopyranosyl-1,6,8,10-tetrahydroxy-2-carboxyl-3-methyl-9(10H)-anthracenone, (10R)10-C-beta-glucopyranosyl-1,6,8,10-tetrahydroxy-3-hydroxymethyl-9(10H)-anthracenone, and (10R)10-C-beta-glucopyranosyl-1,6,8,10-tetrahydroxy-3-methyl-9(10H)-anthracenone. Absolute configurations for each compound were deduced by analyses of CD spectra and comparison with those known similar compounds. The structure of epoxynaphthoquinol was elucidated by spectroscopic methods as 3-acetyl-2-methyl-1,4,5-trihydroxy-2,3-epoxynaphthoquinol, and its relative configuration was determined by a 2D-ROESY experiment. 相似文献
19.
《Phytochemistry》1997,45(5):975-978
The methanol extract of dried stem barks of Tripterygium wilfordii Hook fil. var regelii afforded two new triterpenes: 22-hydroxy-3, 19,24-trinor-D:A-friedoolenane-1(10), 5, 7-triene-2-oic acid methyl ester, named regelone, and 3-methyl-23-ol-oxotingenol; a new diterpene—8β, 19-dihydroxy-3-oxopimar- 15-ene; and three known triterpenes-3-methyl-22-β, 23-diol-6-oxotingenol, tingenin B and cangoronin. Their structures were established on the basis of chemical and spectroscopic studies. ©1997 Elsevier Science Ltd. All rights reserved 相似文献
20.
The structure of atalaphylline, (1; 1,3,5-trihydroxy-4-(γ,γ-dimethylallyl)acridone an alkaloid of Atalantia monophylla, was confirmed by oxidative degradation and by total synthesis. The synthesis involved the preparation of 1,3,5-trihydroxy-9-acridone followed by direct prenylation to give atalaphylline and a monoprenylated product. 相似文献