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1.
The activity of microorganisms is a decisive factor in the transformation of the essential and, at the same time, toxic selenium (Se) in marine waters. This review provides an analysis of the literature data on the microbiological regulation of the state of Se in marine waters: the role of microorganisms in eliminating toxic Se from marine waters through precipitation of reduced Se forms and in the reverse process, transformation of Se into a form available to be taken up by organisms and involvement of this element in the biogeochemical cycle. The processes of transformation of the oxidized and reduced Se forms with the participation of microorganisms in marine waters are considered. It has been shown that in anaerobic conditions bacteria use the oxidized Se forms as electron acceptors (reduction). Bioavailable selenite and selenate ions are formed in the case of aerobic oxidation. Biotransformation of dissolved Se is a key mechanism for the formation of methylated gaseous Se forms in marine waters as one of the ways to remove this element from the aquatic environment.  相似文献   

2.
Current trends in biogeochemical research in the former USSR are exemplified for the trace element selenium (Se). Vast regions of the former USSR are low in Se, giving rise to selenium deficiency diseases in animals and to Kaschin-Beck disease in humans, whereas isolated high-Se regions are comparatively rare. The Se content of plants depends on geological soil-type and secondary processes such as weathering and leaching. In general, a direct correlation between the Se content of feedstock and of the blood in animals is observed, whereas corresponding data for humans remain to be accumulated.  相似文献   

3.
The marine coccolithophore Emiliania huxleyi (Haptophyta) requires selenium as an essential element for growth, and the active species absorbed is selenite, not selenate. This study characterized the selenite uptake mechanism using ??Se as a tracer. Kinetic analysis of selenite uptake showed the involvement of both active and passive transport processes. The active transport was suppressed by 0.5 mM vanadate, a membrane-permeable inhibitor of H?-ATPase, at pH 8.3. When the pH was lowered from 8.3 to 5.3, the selenite uptake activity greatly increased, even in the presence of vanadate, suggesting that the H? concentration gradient may be a motive force for selenite transport. [??Se]Selenite uptake at selenite-limiting concentrations was hardly affected by selenate, sulfate and sulfite, even at 100 μM. In contrast, 3 μM orthophosphate increased the K(m) 5-fold. These data showed that HSeO??, a dominant selenite species at acidic pH, is the active species for transport through the plasma membrane and transport is driven by ΔpH energized by H?-ATPase. Kinetic analysis showed that the selenite uptake activity was competitively inhibited by orthophosphate. Furthermore, the active selenite transport mechanism was shown to be induced de novo under Se-deficient conditions and induction was suppressed by the addition of either sufficient selenite or cycloheximide, an inhibitor of de novo protein synthesis. These results indicate that E. huxleyi cells developed an active selenite uptake mechanism to overcome the disadvantages of Se limitation in ecosystems, maintaining selenium metabolism and selenoproteins for high viability.  相似文献   

4.
人体硒代谢与硒营养研究进展   总被引:1,自引:0,他引:1  
硒是人体所必需的重要微量营养元素,综述了当前国内外人体硒代谢与硒营养的研究进展,包括硒源形式与吸收、人体的硒含量与分布、硒的代谢途径、硒的生物活化形式、硒与疾病、硒中毒和硒的安全摄入量。在此基础上,提出了针对我国硒资源分布、硒反应症分布和居民膳食结构硒摄入量的研究建议,为满足居民通过膳食和补充剂补硒预防和治疗疾病提供理论和实践指导。  相似文献   

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7.
Selenium (Se) is an essential trace element unevenly distributed on the Earth’s crust with low selenium regions predominating. To prevent selenium-deficiency diseases in livestock, additions of selenium to animal feed are required and were approved for all species, but the chemical form of the element to be added was not specified. Presently, sodium selenite is still widely employed, although it is not a natural nutritional form of selenium. Its use creates ecological problems and affects human selenium nutriture in as much as the meat, milk, and eggs from animals maintained on selenite contain less selenium than from animals receiving it as selenomethionine, the chief natural nutritional form of the element present in grain crops grown in selenium-adequate regions, or from high-selenium yeast added to feedstock.

Human dietary selenium intakes are sub-optimal in many countries but are considered to be adequate if they reach the currently adopted Recommended Dietary Allowances (RDAs). Their upward revision will be required if the health benefits of selenium are to be fully utilized.  相似文献   

8.
He Q  Yao K 《Bioresource technology》2011,102(3):3578-3580
The capability of Anaeromyxobacter dehalogenans to reduce Se(IV) to Se(0) as a detoxification mechanism suggests a potential role of these ecologically important microorganisms in the biogeochemical cycling of selenium and the control of selenium contamination. However, the reduction of Se(IV) by the energetically versatile A. dehalogenans could be hindered by its ability to use alternative electron acceptors, particularly Fe(III) and humic substances which are ubiquitous in the environment. Indeed, the presence of Fe(III) partially inhibited Se(IV)-reducing activity. Nonetheless, reduction of both Se(IV) and Fe(III) proceeded simultaneously, a characteristic desirable for bioremediation efforts in many environments abundant with Fe(III). The enhancement of Se(IV) reduction by anthraquinone-2,6-disulfonate, a humic substance analog, is advantageous for microbial selenium biotransformation given the broad distribution of humic substances in natural environments, which could be exploited for the design of improved control strategies for selenium pollution.  相似文献   

9.
细菌还原氧化态硒产生红色单质硒的研究进展   总被引:3,自引:0,他引:3  
硒是一种生命必需的微量元素,但高浓度时毒性较强且会造成环境污染。许多细菌可以将亚硒酸盐(SeO32-)或硒酸盐(SeO42-)等毒性较高的氧化态硒还原为毒性较小的红色单质硒(Se°),形成硒-蛋白复合物,它们对于获得最佳补硒方式和治理硒环境污染具有应用潜力。近年来,关于这一生物还原过程,人们进行了大量的研究,包括碳源、氧气、元素硫、谷胱甘肽以及一些氧化还原酶和膜转运蛋白等在内的多种物质都被发现可能影响或参与了细菌对硒的代谢。综述了细菌进行生物还原氧化态硒的影响因素及不同细菌产生红色单质硒机理的研究进展。  相似文献   

10.
Selenium is an essential trace element with antioxidative, antimutagenic, antiviral and anticarcinogenic properties. There is increasing evidence that the dietary selenium intakes are sub-optimal in the populations of many countries and that human cancer mortalities would significantly decline if additional selenium was made available either through supplementation or the fortification of certain foods. An important property of selenium is its interaction with other elements that may be present in foods, the water, the workplace and the environment, e.g. As, Cu, Ni, Co, Cr, Mn, Zn, Cd, Sn, Pb, Hg, Bi, Mo, Ag, Au, etc. The sequestration of elements by selenium represents an efficient natural detoxification mechanism for some of these elements but also results in the physiological inactivation of selenium. Animal experiments confirm that the chronic exposure to low levels of these elements abolishes the cancer-protective effect of selenium. Human cancer is likewise significantly determined by the interactions of selenium with other elements, as evidenced by epidemiological, ecological and case-control studies. Cadmium, for example, is a key risk-increasing element for prostate cancer; for breast cancer, Cd, Cr, Zn are mainly contributing; for bronchial cancer (in smelter workers), Cd, As, Cr, Sb, Co, La, all these elements are in a reciprocal relationship with Se. While selenium remains the key cancer-protective trace element, the interpretation of its mode of action necessitates consideration of the effects of selenium antagonistic elements.  相似文献   

11.
Selenium is present in plasma and tissues in specific and non-specific forms. The experiments reported here were carried out to clarify some factors that affect these forms of the element in plasma. A selenium-replete human subject was given 400 microg of selenium daily for 28 days as selenomethionine and, in a separate experiment, as selenate. The selenomethionine raised plasma and albumin selenium concentrations. Selenate did neither. The molar ratio of methionine to selenium in albumin was approximately 8000 under basal and selenate-supplemented conditions but 2800 after selenomethionine supplementation. This demonstrates that selenium from selenomethionine, but not selenium from selenate, can be incorporated into albumin, presumably as selenomethionine in the methionine pool. Selenocysteine incorporation into albumin was studied in rats using (75)Se-selenocysteine. No evidence was obtained for incorporation of (75)Se into albumin after exogenous administration or endogenous synthesis of (75)Se-selenocysteine. Thus, selenocysteine does not appear to be incorporated non-specifically into proteins as is selenomethionine. These findings are in support of selenomethionine being a non-specific form of selenium that is metabolized as a constituent of the methionine pool and is unaffected by specific selenium metabolic processes. No evidence was found for non-specific incorporation of selenium into plasma proteins when it was administered as selenate or as selenocysteine. These forms of the element appear to be metabolized by specific selenium metabolic processes.  相似文献   

12.
硒肥在地方特色生物资源中的应用研究进展   总被引:1,自引:0,他引:1  
硒是人类健康所必需的微量元素,现有硒肥利用的报道主要集中于对传统的粮食和经济作物开展人工施加硒肥。对地方特色水果、蔬菜、药食同源植物为代表的地方特色生物资源施用硒肥进行富硒化利用研究报道较少。为逐渐满足缺硒和低硒地区居民补硒的需求,科学开展优势特色生物资源利用,本文综述了这方面的研究进展,并展望了未来特色生物资源人工补硒的前景和发展方向。  相似文献   

13.
微生物硒代谢机制研究进展   总被引:9,自引:0,他引:9  
硒(Se)是人与动物生命必需的微量元素,在医学保健和工业制造方面有着广泛的应用。硒在环境中有四种价态,包括硒酸盐Se O42-(+6)、亚硒酸盐Se O32-(+4)、单质硒Se0(0)和硒化物Se2-(-2)。微生物在硒的形态转化中扮演了重要的角色,影响着环境中硒的生物地球化学循环。本文主要从自然界中硒的循环以及微生物与硒代谢机制两个方面阐述微生物对硒的生物地球化学循环的重要性。  相似文献   

14.
Selenium–Mercury Interactions in Man and Animals   总被引:4,自引:0,他引:4  
Selenium–mercury interactions were most extensively studied in relation to alleviation of Hg toxicity by added selenium. This presentation considers the influence of mercury on endogenous selenium, on its tissue and cellular “status” after lifelong or acute exposure to mercury vapor (Hgo). Discussed are data obtained from (1) humans living near or working in a mercury mine, and (2) rats experimentally exposed in the mine. Mercury vapor is unique—or similar to methylmercury—because of its ability to penetrate cell membranes and so invade all cells, where it is oxidized in the biologically active form (Hg++) by catalase. Such in situ-generated ions can react with endogenously generated highly reactive Se metabolites, like HSe−, and render a part of the selenium unavailable for selenoprotein synthesis. Data on human populations indicate that in moderate Hg exposure combined with an adequate selenium supply through diet, Se bioavailability can be preserved. On the other hand, the results of an acute exposure study emphasize the dual role of selenium in mercury detoxification. Besides the well-known Se coaccumulation through formation of nontoxic Hg–Se complexes, we observed noticeable Se (co)excretion, at least at the beginning of exposure. The higher Hg accumulation rate in the group of animals with lower basal selenium levels can also point to selenium involvement in mercury excretion. In such conditions there is a higher probability for decreased selenoprotein levels (synthesis) in some tissues or organs, depending on the synthesis hierarchy.  相似文献   

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16.
Cells cultivated under standard conditions were highly deficient in tocopherol, selenium, and glutathione peroxidase (GPx) activities. We investigated whether and to what extent the addition of different selenocompounds to growth media would alter biochemical, physiological, and pathophysiological parameters of cultured liver cells. Cellular uptake of selenium, GPx activities, and cytoprotection were measured and compared in human hepatoma cells (HepG2). Selenite and selenocystine were Se donors of high bioavailability (i.e., with these culture supplements, the increased Se uptake, induction of GPx isoenzymes, and protection of treated cells from lipid hydroperoxides were well correlated). In contrast, selenium from selenomethionine was incorporated into cellular proteins but had no effect on GPx activities or cytoprotection. The data show that not all selenium donors provide selenium, which is bioactivated to act as antioxidant. Thus, cellular selenium content, in general, did not correlate with cytoprotective activity of this trace element. However, cellular GPx activities at different times, with different concentrations, and with different Se donors always correlated with protection from lipid hydroperoxides and may, thus, represent a more reliable parameter to define adequate Se supply.  相似文献   

17.
18.
Brown TA  Shrift A 《Plant physiology》1981,67(5):1051-1053
Protein fractions from three selenium-tolerant and three selenium-sensitive Astragalus species, grown in the presence of [75Se]selenate, were analyzed for their selenium content. Though tolerant species are known to accumulate considerably more selenium than do sensitive plants, protein fractions from the three selenium accumulators were found to contain significantly less selenium (0.46 to 0.57 picomoles selenium per milligram protein) than did protein fractions from the three nonaccumulators (4.17 to 5.02 picomoles selenium per milligram protein). Under similar conditions, seedlings of Vigna radiata (L.) Wilczek had taken up selenium (6.31 picomoles selenium per milligram protein) at levels comparable to those observed in the proteins of the nonaccumulator Astragali. These results establish that the ability to tolerate and to circumvent the toxic effects of selenium, characteristic of the accumulator species of Astragalus, is associated with a reduced incorporation of this element into protein.  相似文献   

19.
Recently published biochemical data suggest the significant role of selenium compounds as the adjuvants combined with L: -thyroxine therapy, which can reduce antithyroid peroxidase antibodies' (TPOAb) levels in patients with Hashimoto disease. The study was undertaken to document in a more detailed way the changes in parameters expressing the thyroid and ovarian function brought about by selenium supplementation (50-100 microg/day) in a woman undergoing autoimmune thyroiditis (AIT) therapy. This prospective observational case study lasted for 14 months plus additional 5 months as a follow-up period. Parameters reflecting selenium status, thyroid metabolism, and sex hormones secretion were determined at the onset and end of the study period, as well as in some of its middle points. During the supplementation trial, serum selenium (Se) increased by 45% and plasma glutathione peroxidase (GPX3) by 21%. TPOAb decreased by 76%. All other parameters also fluctuated during the supplementation period, but all results were always within normal physiological ranges. After withdrawal of the supplementation, the sharp fall of Se and GPX3 promptly occurred, and this phenomenon was accompanied with a marked increase in TPOAb. This report stresses the importance of selenium supplementation in AIT treatment. However, the efficiency and durability of the effect of Se supplementation on the TPOAb titer remain an open question. The clarification of mechanism(s) underlying Se interaction with autoimmune processes should throw new light on this issue.  相似文献   

20.
纳米元素硒的生物合成及生物活性   总被引:11,自引:0,他引:11  
利用生物载体富集和转化硒是获取活性硒形式的合理途径。一定条件下,生物体对硒的代谢可产生红色纳米级胶体元素硒,传统认为,生物体内元素硒的合成是生物体解除硒毒性的有效机制。最近的一些研究发现,人工合成以蛋白质为分散剂的红色纳米元素硒具有抑制肿瘤细胞生长、抗氧化、免疫调节及延缓衰老等生物活性。提示生物来源的纳米元素硒可能具有潜在应用价值。对纳米元素硒及其生物活性的研究进展进行了综述。  相似文献   

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