Is your software usable?

‘Ease-of-use…comes from conducting systematic usability engineering activities throughout the project lifecycle.’     

Is your initiator really necessary?

There is little hard evidence for the involvement of specific genotoxic initiators in the pathogenesis of the common carcinoma. Recent findings suggest that sporadic carcinogenesis is a dynamic and probabilistic process which requires a critical mass of abnormal cells for its expression, and that this requirement may distinguish the evolution of carcinomas from that of paediatric or haematologic malignancies. The proposal that specific carcinogens are neither necessary nor sufficient for tumourigenesis is consistent with the growing realization that aberrant expression of specific oncogenes is neither necessary nor sufficient for cellular transformation. These new perspectives have major implications for basic research strategy and public health policy.     

Cell cycling? Check your brakes

If there was any pervasive theme at the Cold Spring Harbor Cell Cycle Meeting (May 15 19, 2002), it was negativity. This is clearly the age of the negative cell cycle regulator, as a large percentage of the talks focused on the critical roles of cell cycle inhibitory networks.     

Not too excited? Thank your endocannabinoids

Endocannabinoids can mediate neuroprotection, but it is not known how. In this issue of Neuron, Monory et al. use mutant mice and localized viral targeting to produce conditional knockouts of the cannabinoid CB1 receptor. They show that protection against kainic acid-induced seizures and cell death is conferred by CB1Rs on hippocampal glutamatergic nerve terminals.     

So what do your sugars do?

Up to about fifteen years ago the above question was quite often asked of glycoconjugates enthusiasts. It was always a silly question, the answer being ‘How many doings do you want to hear about?’ Since then our understanding of the structures, biosynthesis and varied functions of the glycoconjugates has developed incredibly and come to have a major impact on much of present-day biological and medical research.