血清CREG蛋白在急性心肌梗死早期的表达研究

目的：探讨血清中CREG蛋白在急性心肌梗死发作早期的表达情况,尝试为临床心肌缺血的极早期诊断提供一种新的血清标志分子。方法：在2010年6月至2010年11月期间,入选在沈阳军区总医院心内科住院治疗的急性ST段抬高型心肌梗死患者50例及非AMI对照50例,于AMI组胸痛发作后的不同时间点采血测定CK、CK—MB、LDH和cTnT,同时应用Westem blot技术测定血清中CREG蛋白的含量,并与对照组比较。结果：AMI组发病72小时内的血清中CREG蛋白表达均较对照组有不同程度的增高（P〈0．05）。胸痛开始2h内,AMI组血清中CREG的含量即明显增高,其在2h、4h及6h的含量显著高于对照组（P〈0．001）。在胸痛已经发作2小时内,两组间血清cTnT、CK、CK-MB及LDH水平比较无统计学意义（P〉0．05）。结论：CREG在AMI患者血清中的表达增高．其在血清中表达时间早于cTNT及CK-MB。     

血清CREG蛋白在急性心肌梗死早期的表达研究

目的:探讨血清中CREG蛋白在急性心肌梗死发作早期的表达情况,尝试为临床心肌缺血的极早期诊断提供一种新的血清标志分子。方法:在2010年6月至2010年11月期间,入选在沈阳军区总医院心内科住院治疗的急性ST段抬高型心肌梗死患者50例及非AMI对照50例,于AMI组胸痛发作后的不同时间点采血测定CK、CK-MB、LDH和cTnT,同时应用Western blot技术测定血清中CREG蛋白的含量,并与对照组比较。结果:AMI组发病72小时内的血清中CREG蛋白表达均较对照组有不同程度的增高(P<0.05)。胸痛开始2h内,AMI组血清中CREG的含量即明显增高,其在2h、4h及6h的含量显著高于对照组(P<0.001)。在胸痛已经发作2小时内,两组间血清cTnT、CK、CK-MB及LDH水平比较无统计学意义(P>0.05)。结论:CREG在AMI患者血清中的表达增高,其在血清中表达时间早于cTNT及CK-MB。     

CK-MBmass, hs-cTnT及CK-MB与急性心肌梗死的相关性及其联合诊断价值

摘要 目的：研究肌酸激酶同工酶质量（CK-MBmass)、肌酸激酶同工酶（CK-MB）和高敏心肌肌钙蛋白T（hs-cTnT）在急性心肌梗死患者（AMI）血清中的含量,并探讨三者联合对AMIDE诊断价值。方法：选择2018年1月到2021年10月我院收治的AMI患者90例作为研究组,并选择同期在我院体检健康志愿者40例作为对照组,比较两组AMI患者血清CK-MBmass,hs-cTnT和CK-MB。根据Killp分级法将不同心力衰竭将AMI患者分为II、III和IV级,并根据心肌梗死范围将AMI患者分为轻度、中度和重度心肌梗死组。比较不同AMI患者血清CK-MBmass,hs-cTnT和CK-MB。通过受试者工作曲线计算血清CK-MBmass,hs-cTnT和CK-MB联合诊断AMI的阳性预测值、阴性预测值、敏感度和特异度。结果：（1）AMI患者血清CK-MBmass,hs-cTnT和CK-MB均显著高于健康志愿者（P<0.05）;（2）AMI患者血清CK-MBmass,hs-cTnT和CK-MB随Killp分级或心肌梗死范围升高而升高（P<0.05）;（3）AMI患者血清CK-MBmass,hs-cTnT,CK-MB与急性心肌梗死患者左室射血分数（LVEF）呈负相关（P<0.05）,与左室舒张末期容积（LVEDd）和梗死范围呈正相关（P<0.05）;（4）血清CK-MBmass,hs-cTnT和CK-MB联合检测急性心肌梗死的阳性预测值、阴性预测值、敏感度和特异度均高于单独诊断。结论：血清CK-MBmass,hs-cTnT和CK-MB在AMI患者含量升高,并且与患者心功能和心肌梗死范围有关,适用于AMI的联合诊断。     

蛇毒清胶囊对眼镜蛇咬伤患者血清CK、LDH、AST活性的影响

目的观察眼镜蛇咬伤后血清CK、LDH、AST活性的变化和蛇毒清胶囊对其的影响. 方法眼镜蛇咬伤2h内的患者120例,随机分为2个组,均给予常规治疗,治疗组加服蛇毒清胶囊,均以7天为1个疗程.分别于就诊时、咬伤后24h测定其血清酶学三项指标:CK、LDH、AST的活性,比较2组酶学的变化和临床疗效.结果2组患者在就诊时(伤后2h内)的酶学三项指标尚未出现明显异常,伤后24h三项指标均明显升高,对照组显著高于治疗组,治疗组疗效优于对照组(P＜0.05).结论蛇毒清胶囊能抑制眼镜蛇咬伤患者血清CK、LDH、AST的升高,对眼镜蛇咬伤患者组织损伤有防治作用.     

心肌坏死标志物联合检测对急性心肌梗死早期诊断及鉴别的价值

目的:探讨心肌坏死标志物联合检测在急性心肌梗死早期诊断及鉴别中的意义。方法:选取2010年12月至2013年5月我院收治的90例患者,45例确诊急性心肌梗死患者为观察组,其余45例非急性心肌梗死患者为对照组。分别采集两组患者静脉血4 m L用于检验。采用免疫抑制法测定患者血清中肌酸激酶(CK)和肌酸激酶同工酶(CK-MB)含量,采用电化学发光法检测肌钙蛋白I(c Tn I)和肌红蛋白(MYO)含量。观察并比较不同时间点两组患者血清中CK、CK-MB、c TnⅠ及MYO含量的变化情况。结果:与对照组比较,观察组的血清CK、CK-MB、c TnⅠ及MYO的含量明显升高,其中CK及MYO升高最为显著,差异具有统计学意义(P0.05)。CK、CK-MB在发病3~6 h后快速升高,24 h达高峰;c TnⅠ前24 h与CK-MB同步,但维持时间较长;MYO在发病后1~2 h发生异常,12 h达峰值(P0.05)。结论:心肌坏死标志物联合检测可提高急性心肌梗死的检出率,有助于疾病的及时发现、诊断和治疗。     

心肌损害标志物的评价及应用策略

根据血清中有关酶（如：天门冬氨酸氨基转移酶(AST)、乳酸脱氢酶(LD)、肌酸激酶及其同工酶(CK-MB)）活性的变化来诊断急性心肌梗塞（AMI）已有多年的历史.近年来,一些蛋白质标志物,如：CK-MB质量,心肌肌红蛋白,心肌肌钙蛋白（cTn）也已逐渐应用于临床诊断.其中心肌肌红蛋白是一项良好的排除心肌梗塞的指标,而心肌肌钙蛋白则是很好的确证指标.CK-MB质量的分析性能高于其活性测定.蛋白质标志物分析还可用于冠心病的危险分级及监测治疗.血清酶分析由于价廉、方法成熟,也不失为有效的AMI辅助诊断指标.需特别注意标本采集时间对结果应用的影响.     

急诊超声心动图联合血清NT-proBNP、cTnI、CK-MB诊断急性心肌梗死的临床价值分析

摘要 目的：研究急诊超声心动图联合血清氨基末端脑钠肽前体（NT-proBNP）、肌钙蛋白（cTnI）和肌酸激酶同工酶（CK-MB）诊断急性心肌梗死（AMI）的临床价值。方法：将2019年12月至2020年6月期间我院收治的82例AMI患者纳入研究,记作病变组。另取同期于我院进行体检的健康者80例作为对照组。比较两组各项超声心动图指标水平,血清NT-proBNP、cTnI和CK-MB水平。分析超声心动图指标与血清NT-proBNP、cTnI和CK-MB的相关性。以受试者工作特征（ROC）曲线分析超声心动图联合血清NT-proBNP、cTnI和CK-MB水平诊断AMI的效能。结果：病变组左心室射血分数（LVEF）低于对照组,而左室舒张末期内径（LVEDD）高于对照组（P＜0.05）。病变组血清NT-proBNP、cTnI和CK-MB水平均高于对照组（P＜0.05）。Pearson检验显示LVEF与血清NT-proBNP、cTnI和CK-MB均呈负相关（r=-0.514、-0.578、-0.532,均P＜0.05）,LVEDD与血清NT-proBNP、cTnI和CK-MB均呈正相关（r=0.625、0.594、0.575,均P＜0.05）。超声心动图联合血清三项诊断AMI的曲线下面积、灵敏度以及特异度均高于超声心动图、血清三项单独诊断。结论：超声心动图联合血清NT-proBNP、cTnI和CK-MB诊断AMI的价值较高,具有一定的临床应用价值。     

双歧三联活菌片与小儿止泻安颗粒对急性腹泻患儿血清IL-7、心肌酶及同工酶水平的影响

目的:探讨双歧三联活菌片联合小儿止泻安颗粒对小儿急性腹泻患儿血清IL-7、心肌酶及同工酶水平的影响。方法:收集我院就诊的120例小儿急性腹泻患者,随机分为实验组和对照组,每组60例。对照组患者给予双歧三联活菌片口服治疗;实验组在对照组基础上给予小儿止泻安颗粒口服治疗。观察并比较两组患者治疗前后血清天门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、乳酸脱氢酶(LDH)、肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、白介素-7(IL-7)以及临床治疗有效率。结果:与治疗前相比,两组患者治疗后AST、ALT、LDH、CK、CK-MB水平均显著下降,IL-7水平明显升高,差异具有统计学意义(P0.05);与对照组相比,实验组患者的血清AST、ALT、LDH、CK、CK-MB水平较低,IL-7水平较高,差异具有统计学意义(P0.05);与对照组相比,实验组患者的临床治疗有效率较高,差异具有统计学意义(P0.05)。结论:双歧三联活菌片联合小儿止泻安颗粒能够降低小儿急性腹泻患者血清心肌酶、同工酶水平,升高IL-7水平,临床疗效较好。     

阻塞性睡眠呼吸暂停综合征对急性心肌梗死患者左心室功能、NT-proBNP、ET-1、GDF-15的影响

摘要 目的：探讨阻塞性睡眠呼吸暂停综合征（OSAHS）对急性心肌梗死（AMI）患者左心室功能、N末端B型利钠肽原（NT-proBNP）、内皮素1（ET-1）、生长分化因子-15（GDF-15）的影响。方法：选取2020年3月至2022年6月于上海交通大学附属第六人民医院行急诊PCI的AMI患者136例,根据呼吸暂停低通气指数（AHI）水平将患者分为非OSAHS组（48例）、轻度OSAHS组（31例）、中度OSAHS组（29例）和重度OSAHS组（28例）。均行心脏超声检查左心室功能指标[左室短轴缩短率（LVFS）、左室射血分数（LVEF）],检测血清NT-proBNP、ET-1、GDF-15、肌酸激酶（CK）、肌酸激酶同工酶MB（CK-MB）、乳酸脱氢酶（LDH）、α-羟丁酸脱氢酶（α-HBDH）水平。采用Pearson相关分析LVFS、LVEF、NT-proBNP、ET-1、GDF-15与AHI的相关性;采用多因素Logistic回归分析AMI合并OSAHS的影响因素。结果：（1）四组患者LVFS、LVEF比较,重度OSAHS组<中度OSAHS组<轻度OSAHS组<非OSAHS组（P<0.05）;（2）四组患者NT-proBNP、ET-1、GDF-15水平比较,重度OSAHS组>中度OSAHS组>轻度OSAHS组>非OSAHS组（P<0.05）;（3）四组患者CK、CK-MB、LDH、α-HBDH水平比较,重度OSAHS组>中度OSAHS组>轻度OSAHS组>非OSAHS组（P<0.05）。（4）Pearson相关性分析显示：AMI患者LVFS、LVEF与AHI均呈负相关（r=-0.632、-0.573,P<0.05）,NT-proBNP、ET-1、GDF-15水平与AHI均呈正相关（r=0.596、0.542、0.517,P<0.05）。（5）Logistic回归分析显示：LVFS（OR=6.379,95%CI：3.215~9.543）、LVEF（OR=3.016,95%CI：1.364~4.668）、NT-proBNP（OR=5.171,95%CI：2.316~8.025）、ET-1（OR=2.751,95%CI：1.334~4.168）、GDF-15（OR=2.447,95%CI：1.143~3.752）、CK（OR=4.108,95%CI：1.615~6.602）、CK-MB（OR=4.500,95%CI：1.860~7.139）、LDH（OR=3.435,95%CI：1.407~5.463）是影响AMI合并OSAHS的独立危险因素（P<0.05）。结论：随着OSAHS病情进展可能加重AMI患者心功能、血管内皮功能、心肌损伤程度,血清NT-proBNP、ET-1、GDF-15水平升高可能是影响AMI患者并发OSAHS的危险因素。     

急性心梗患者血清Fractalkine水平与临床检测指标相关性研究

目的:分析急性心肌梗死(AMI)患者血清Fractalkine水平,并探讨其与AMI相关临床指标包括白介素-6(IL-6)、C反应蛋白(CRP)、B型利钠肽(BNP)、肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)等的相关性,以期进一步了解Fractalkine在动脉粥样硬化性疾病中的作用。方法:选取AMI患者与健康对照患者各38例。采用ELISA方法检测研究对象血清中的Fractalkine水平,临床相关检测指标从检验科获取,并进行相关性分析。结果:与对照组相比,急性心梗患者组血清Fractalkine、IL-6、CRP、BNP、CK、CK-MB、TC、LDL-C、LDH表达水平均显著升高,而血清HDL-C水平明显降低,差异均具有统计学意义(P0.05)。AMI患者血清Fractalkine水平与血清CK、CK-MB、TC、LDL-C水平均存在显著正相关性(r=0.538、r=0.495、r=0.509、r=0.557,P0.05)。结论:急性心梗患者血清Fractalkine水平异常上调,且与血清CK、CK-MK、TC、LDL-C水平呈显著正相关,Fractalkine可能作为一个AMI的诊断和治疗参考指标。为进一步揭示心血管疾病的发病机制以及有效防治,提供新的思路。     

人心脏型脂肪酸结合蛋白快速检测试剂盒的临床验证性研究

目的评价H-FABP快速检测试剂盒对急性心肌梗死(AMI)的早期诊断效果。方法比较H-FABP、CK、CK-MB和cTnT四种心肌标志物在AMI发作后6 h内的敏感性、准确性和时效性;比较H-FABP快速检测试剂盒对AMI患者和非AMI患者诊断的特异性。结果 H-FABP快速检测试剂盒的检测结果与临床诊断结果符合率为100%;在AMI发作后6 h内,H-FABP的敏感性和准确性优于CK、CK-MB,与cTnT相当。8例肾衰竭患者100%显示阳性,心源性疾病中主动脉关闭不全有1例(2.44%),房间隔缺损有2例(4.88%)显示阳性。结论 AMI发作后6 h内,H-FABP快速检测试剂盒对其具有较好的诊断价值。     

Ascorbic Acid Ameliorates Cardiac and Hepatic Toxicity Induced by Azithromycin-Etoricoxib Drug Interaction

The complexity of prescribing safe and effective drug therapy is still challenging. Due to the increased number of medications taken by patients, the potential for drug-drug interactions has clinically important consequences. This study focuses on the potential drug-drug interaction between azithromycin and etoricoxib and the possibility of counteracting this adverse reaction by giving ascorbic acid intraperitoneally to male albino rats. Sixty adult male albino rats weighing 150–180 g were used. The rats were allocated into six equal groups. One group was a control, and the others were given azithromycin, etoricoxib, either alone or combination, with one group treated with ascorbic acid and the last group treated with the drug combination and ascorbic acid. Blood samples were collected for measuring AST, ALT, LDH, CK-MB, and troponin alongside antioxidant enzymes and histopathological examination for both liver and heart tissue. The results showed both hepatic and cardiac damage in azithromycin and etoricoxib groups represented by increasing levels of heaptoc enzymes (ALT, AST, LDH, CK-MB, and troponin) with declining antioxidant enzymes and elevation of malondialdehyde and the appearance of hepatic and cardiac toxicities. Upon administration, ascorbic acid ameliorated all the mentioned biochemical parameters. In conclusion, ascorbic acid has great antioxidant capacities and hepatic and cardiac ameliorative effects and can alleviate drug interaction toxicity.     

急性脑梗死患者血清心肌酶学变化的临床意义及相关危险因素分析

目的：探讨急性脑梗死患者血清心肌酶学变化与预后的关系及导致急性脑梗死患者心肌酶学变化的相关危险因素。方法：回顾性分析临床及影像资料齐全且确诊的140例急性脑梗死患者（发病14天内）,根据有无血清心肌酶学升高分为血清心肌酶学升高的急性脑梗死组A组（43例）,血清心肌酶学正常的急性脑梗死组B组（97例）,应用美国国立卫生研究院卒中量表评分（NIHSS）比较两组神经功能缺损情况,并对两组病人血清心肌酶学（包括天冬氨酸氨基转移酶（AST）、肌酸激酶（CK）、肌酸激酶同工酶（CK-MB）、乳酸脱氢酶（LDH）、血糖、血脂、纤维蛋白原和血压等结果进行分析。结果：A组（31%）患者血清心肌酶学均增高,与B组比较均有显著性差异（P〈0.01）;发病后1天A、B两组患者临床神经功能缺损程度评分无显著性差异,发病后4、8、10天A、B两组患者临床神经功能缺损程度评分有显著性差异（P〈0.01）;A组高血压、糖尿病与B组比较有显著性差异（P〈0.05）;而血脂及纤维蛋白原两组比较无显著性差异。结论：急性脑梗死患者血清心肌酶学升高者预后不良;高血压、糖尿病是急性脑梗死患者血清心肌酶学升高的相关危险因素。     

Juglone from Walnut Produces Cardioprotective Effects against Isoproterenol-Induced Myocardial Injury in SD Rats

Therapeutic and/or preventive interventions using phytochemical constituents for ischemic heart disease have gained considerable attention worldwide, mainly due to their antioxidant activity. This study investigated the cardioprotective effect and possible mechanism of juglone, a major constituent of the walnut tree, using an isoproterenol (ISO)-induced myocardial infarction (MI) model in rats. Rats were pretreated for five (5) days with juglone (1, 3 mg/kg, i.p) and atenolol (1 mg/kg, i.p) in separate experiments before inducing myocardial injury by administration of ISO (80 mg/kg, s.c) at an interval of 24 h for 2 consecutive days (4th and 5th day). The cardioprotective effect of juglone was confirmed through a lead II electrocardiograph (ECG), cardiac biomarkers (cTnI, CPK, CK-MB, LDH, ALT and AST) and histopathological study. The results of our present study suggest that prior administration of juglone (1 and 3 mg/kg) proved to be effective as a cardioprotective therapeutic agent in reducing the extent of myocardial damage (induced by ISO) by fortifying the myocardial cell membrane, preventing elevated T-waves, deep Q-waves in the ECG, heart to body weight ratio, infarction and also by normalizing cardiac marker enzymes (cTnI, CPK, CK-MB, LDH, ALT and AST) and histopathological changes, such as inflammation, edema and necrosis. In conclusion, this study has identified phytochemical constituents, in particular juglone, as a potential cardioprotective agent.     

Baseline serum levels of cardiac biomarkers in patients with stable coronary artery disease

Stable coronary artery disease (CAD) can cause repetitive reversible myocardial ischaemia, and it seems to be possible that reversibly injured myocardium releases small amounts of soluble cytoplasmic proteins. Hence, the aim was to evaluate the effect of stable CAD on baseline serum levels of cardiac biomarkers. We studied 68 consecutive outpatients referred for gated myocardial perfusion imaging. Before a treadmill exercise test, blood samples for measurement of creatine kinase (CK), CK-myocardial band (CK-MB) mass, myoglobin, aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) were collected. Normal perfusion patterns were detected in 29 (43%) patients (group 1) and perfusion defects were detected in 39 (57%) patients (group 2). Baseline serum levels of biomarkers except CK were significantly higher in group 2 (p=0.001). Stable CAD increases baseline levels of CK-MB mass, myoglobin, AST and LDH in the serum and this increase is related to the extent and severity of the perfusion defect and to some extent the ejection fraction of the left ventricle.     

Baseline serum levels of cardiac biomarkers in patients with stable coronary artery disease

Stable coronary artery disease (CAD) can cause repetitive reversible myocardial ischaemia, and it seems to be possible that reversibly injured myocardium releases small amounts of soluble cytoplasmic proteins. Hence, the aim was to evaluate the effect of stable CAD on baseline serum levels of cardiac biomarkers. We studied 68 consecutive outpatients referred for gated myocardial perfusion imaging. Before a treadmill exercise test, blood samples for measurement of creatine kinase (CK), CK-myocardial band (CK-MB) mass, myoglobin, aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) were collected. Normal perfusion patterns were detected in 29 (43%) patients (group 1) and perfusion defects were detected in 39 (57%) patients (group 2). Baseline serum levels of biomarkers except CK were significantly higher in group 2 (p=0.001). Stable CAD increases baseline levels of CK-MB mass, myoglobin, AST and LDH in the serum and this increase is related to the extent and severity of the perfusion defect and to some extent the ejection fraction of the left ventricle.     

Increased expression of calcium-sensing receptors in atherosclerosis confers hypersensitivity to acute myocardial infarction in rats

Acute myocardial infarction (AMI) is a leading cause of death worldwide. Most cases of AMI result from coronary atherosclerosis (AS). The pathogenic mechanisms underlying AS lesions and AMI are incompletely understood. Calcium-sensing receptors (CaSR) belong to a family of G-protein-coupled receptors. We previously discovered that CaSR was expressed in the heart tissue of adult rats. CaSR may contribute to AMI in AS. We initially established a rat model of AS by injection of vitamin D(3) and feeding with a high-fat diet. Isoproterenol (ISO) was used to induce AMI. The MB isoenzyme of creatine kinase (CK-MB), lactate dehydrogenase (LDH), cardiac troponin T (cTnT), tetrazolium chloride staining, and cardiac function parameters were selected as indicators of myocardial damage or necrosis. Cardiac apoptosis was analyzed by transferase dUTP nick-end labeling (TUNEL) assay. Expression of CaSR, Bcl-2, Bax, caspase-3, p-ERK1/2, p-JNK, and p-p38 were determined by Western blot analysis. Compared with the control group, levels of cTnT, CK-MB, and LDH; number of TUNEL-positive cells; and expression of CaSR, Bax, caspase-3, p-ERK1/2, p-JNK and p-p38, were significantly increased, whereas cardiac function and expression of Bcl-2 were decreased markedly in isoproterenol (ISO)-treated group (C/ISO) and AS groups. These changes were significant in the AS/ISO group than in the C/ISO group or AS group. The upregulation of CaSR during AS formation renders hypersensitivity to AMI. Activation of the pro-apoptotic mitochondria pathway and JNK-p38 MAPK pathway triggered by increased expression of CaSR may be one of molecular mechanisms underlying AMI in AS.     

急性心肌梗死患者血清外连素、MEG3、HSP-70水平与心肌损伤标志物及心血管不良事件的关系研究

目的:研究急性心肌梗死(AMI)患者血清外连素、母系表达基因3(MEG3)、热休克蛋白70(HSP-70)水平与心肌损伤标志物及心血管不良事件的关系。方法:选取2015年1月-2020年1月期间我院接受治疗的AMI患者200例作为AMI组,另选取同期在我院健康体检的人群100例作为对照组,对比对照组、AMI组心肌型肌酸激酶同工酶(CK-MB)、肌红蛋白(Myo)、心肌肌钙蛋白Ⅰ(cTnI)、外连素、MEG3 RNA、HSP-70。对比心血管不良事件与非心血管不良事件患者的CK-MB、Myo、cTnI、外连素、MEG3 RNA、HSP-70水平。采用Pearson相关性分析AMI患者血清外连素、MEG3 RNA、HSP-70水平与心肌损伤标志物的关系。结果:AMI组CK-MB、Myo、cTnI、外连素、MEG3 RNA、HSP-70均高于对照组(P<0.05)。随访过程中,有59例发生心血管不良事件纳为心血管不良事件组,剩余141例未发生心血管不良事件纳为非心血管不良事件组。心血管不良事件组患者的CK-MB、Myo、cTnI、外连素、MEG3 RNA、HSP-70均高于非心血管不良事件组(P<0.05)。AMI患者外连素、MEG3 RNA、HSP-70水平与CK-MB、Myo、cTnI均呈正相关(P<0.05)。结论:AMI患者中外连素、MEG3 RNA、HSP-70均呈现异常高表达,且与心肌损伤标志物密切相关,可考虑作为AMI患者早期确诊的新型标志物。