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1.
《Electronic Notes in Theoretical Computer Science》1989,74(6):417-424
Human transcallosal responses (TCRs) were elicited by focal magnetic oil (MC) stimulation of homologous sites in contralateral frontal cortex and compared with those to focal anodic stimulation. With MC stimulation, the TCR consisted of an initially positive wave with an onset latency of 8.8–12.2 msec, a duration of 7–15 msec, and an amplitude which reached up to 20 μV, sometimes followed by a broad low amplitude negative wave. With anodic stimulation, a similar response was obtained in which the positive wave was similar in latency and maximum amplitude, but had a greater duration. With anodic stimulation, not only was the TCR threshold below that for contralateral movement, but it reached substantial size at intensities below motor threshold. With MC stimulation, contralateral arm movement and scalp corticomotor potentials were observed when the MC was displaced posteriorly towards the central sulcus. Unlike with anodic stimulation, the MC evoked TCR was usually not preceded by a prominent EMG potential from temporalis muscle and was not associated with subject discomfort.The TCR provides unique information concerning the functional integrity of callosal projection neurons, their axons and transsynaptic processes in recipient cortex. This information may prove useful in the evaluation of intrinsic cerebral mechanisms and in establishing cortical viability. 相似文献
2.
S. I. Shumikhina 《Neurophysiology》1984,16(4):394-400
Recovery curves of evoked potentials in the association and visual cortex during paired stimulation of the pulvinar in chronic experiments on alert cats were shown to be similar in character. Depression of the test response was observed only if the interval between stimuli was of the order of 10 msec, but if it was 40 msec considerable (2–4 times) facilitation of the second response was observed, mainly on account of an increase in the negative component N1. Facilitation was less marked if the intervals were from 60 to 100 msec, and they decreased gradually to an interval of 200 msec. The recovery curve of cortical evoked potentials during paired stimulation of the lateral geniculate body differed considerably from the recovery curve during paired stimulation of the pulvinar and was characterized by a gradual increase in amplitude of the second response — from its almost total suppression with an interval of 10 msec to slight facilitation with an interval of 200 msec. If intervals of 10 to 80 msec were used, the test response was restored more slowly in the association cortex than in the visual cortex. The results are discussed from the standpoint of differences in the character of intracortical spread of excitation as a result of activation of geniculo-cortical and pulvinar-cortical pathways of conduction of information.Institute of Higher Nervous Activity and Neurophysiology, Academy of Sciences of the USSR, Moscow. Translated from Neirofiziologiya, Vol. 16, No. 4, pp. 497–505, July–August, 1984. 相似文献
3.
《Electronic Notes in Theoretical Computer Science》1993,88(1):20-27
In this study we have demonstrated an enhancement of cortically generated wave forms of the somatosensory evoked potential (SEP) following magnetic pulse stimulation of the human brain. Subcortically generated activity was unaltered. The enhancement of SEP amplitude was greatest when the median nerve was stimulated 30–70 msec following magnetic pulse stimulation over the contralateral parietal scalp. We posit that the enhancement of the SEP is the result of synchronization of pyramidal cells in the sensorimotor cortex resulting from the magnetic pulse. 相似文献
4.
Unit activity in the visual (area 17) and sensomotor (areas 4 and 6) cortex in response to an optical stimulus up to 1000 msec in duration was investigated by extracellular recording in acute experiments on cats anesthetized with chloralose (70 mg/kg body weight). Comparative analysis of the types of unitary responses and the durations of the intervals of functional changes showed that: 1) The number of neurons generating on-off responses was about 25% in the visual cortex and 100% in the sensomotor cortex; 2) the intervals of functional changes of the neurons were equal in length to the time intervals of on-off discharges; 3) together with a single time range (200–500 msec), for each area studied specific ranges also exist: from 0 to 200 msec for the visual cortex and from 500 msec and more for the sensomotor cortex; 4) the latent period of after-discharge is equal to the duration of the intervals of functional changes. The results were analyzed from the standpoint of reflection of temporal parameters of optical stimuli by neurons of the sensomotor cortex.A. A. Zhdanov Leningrad State University. Translated from Neirofiziologiya, Vol. 7, No. 4, pp. 365–371, July–August, 1975. 相似文献
5.
The dynamics of the intensity function of 32 neurons in area 17 of the visual cortex to photic stimuli of optimal size, shape, and orientation flashing in the center of the receptive field was studied by the time slices method, with a step of 10 or 20 msec, in unanesthetized, curarized cats. All neurons tested showed instability of their intensity function reflected in characteristics of successive fragments of the response: It changed both in preferred intensity and in width of the intensity range within which the neuron generated an above-threshold response. In 72% of cases the preferred intensity for the neuron changed successively during the 4–200 msec after the beginning of stimulation by 4–36 dB from greater toward lesser brightnesses, but later it changed more rapidly (in 20–60 msec), rising again apparently in a jump. In four cases the response optimum was shifted up the intensity scale from its initial value by 10–20 dB. Analysis showed that the observed effects are the simple result of the shape of the relationship between temporal characteristics of the response (latent period, time taken to reach the maximum, and time of ending of the burst) to photic stimulus intensity. The possible functional role of these effects for dynamic time coding of information on brightness of photic stimuli by visual cortical neurons is discussed. 相似文献
6.
S. B. Isabekova 《Neurophysiology》1974,6(2):97-103
Two types of evoked potentials are recorded in the tectum mesencephali in response to electrical stimulation of the forebrain surface of the turtleEmys orbicularis. The results of a layer-by-layer analysis show that evoked potentials of type I in response to stimulation of the hippocampal and piriform cortex are generated outside the tectum. Evoked potentials of type II, consisting of two surface-negative components, are recorded in the tectum in response to stimulation of the rostro-central surface of the forebrain. The first component appeared after a latent period of 20 msec and lasted 40–60 msec; the second component appeared after 80–100 msec and lasted 100–300 msec. Layer-by-layer and pharmacological analysis showed that the first component of the type II evoked potential is generated in the tegmental structures of the mesencephalon, whereas the second (long-latency) is generated in the tectum. The tectal origin of the second component is confirmed by its interaction with the tectal response to photic stimulation or to electrical stimulation of the optic nerve, evidence that these evoked potentials are generated by common structures. The efferent pathway from the dorsal cortex to the primary visual center is unilateral and has features of polysynaptic projections (long latent period, low lability). 相似文献
7.
A. N. Balashova 《Neurophysiology》1973,5(6):482-487
Unit responses of the sensomotor cortex to paired electrical stimulation and visual cortex, applied either simultaneously or after various delays (from 0 to 200 msec) depend on the order of application of the stimuli and on the interval between them. If stimulation of the sensomotor cortex was used in a conditioning role the response continued unchanged when the intervals between stimuli were increased to 200 msec. If, however, stimulation of the sensomotor cortex had a testing role interaction was observed between the stimuli so that responses to both first and second stimuli were blocked; this was exhibited most clearly for intervals of 40–80 msec between stimuli. The blocking effect persisted on some neurons with delays of up to 200 msec between stimuli, while the response of others to both the first and the second stimulus was restored.Institute of Higher Nervous Activity and Neurophysiology, Academy of Sciences of the USSR, Moscow. Translated from Neirofiziologiya, Vol. 5, No. 6, pp. 628–635, November–December, 1973. 相似文献
8.
Responses of 251 neurons in the anterior part of the middle suprasylvian gyrus to stimulation of primary sensory (auditory, visual, somatosensory) areas and also to acoustic, visual, and somatosensory stimuli were studied in acute experiments on cats anesthetized with chloralose (40 mg/kg) and pentobarbital (20 mg/kg). Three groups of neurons were distinguished by their responses to stimulation of the primary sensory areas: those responding by an increased firing rate (117) or by inhibition (35) and those not responding (99). Responses of 193 neurons to stimulation of the peripheral afferent systems were analyzed. Neurons of the parietal associative cortex responded more frequently to cortical stimulation than to peripheral. By the duration of the latent period of their response to cortical stimulation the neurons were divided into three groups: those with short (less than 20 msec), medium (20–30 msec), and long latent periods (over 30 msec). The first group was the largest.Kemerovo State Medical Institute. Translated from Neirofiziologiya, Vol. 4, No. 5, pp. 524–530, September–October, 1972. 相似文献
9.
Responses of 98 neurons of the reticular (R) and 72 neurons of the ventral anterior (VA) thalamic nuclei to stimulation of various zones of the orbitofrontal cortex were investigated in acute experiments on cats immobilized with D-tubocurarine. Not all zones of this cortex were found to be connected equally closely with R and VA. Most of the R (82.7%) and VA (66.7%) neurons responded to stimulation of the proreal gyrus, and fewest (37.3 and 48.9%, respectively) to stimulation of the posterior orbital gyrus. Among the responding neurons, 85.2–86.3% of R cells and 78.2–81.2% of VA cells were excited by cortical stimulation and the rest were inhibited. Excitation was expressed as the appearance of a single spike or of discharges of varied duration in response to each stimulus. The latent period of the spike responses varied from 0.5 to 55.0 msec and the minimal latent period of the discharges was 0.8 msec and its maximal value over 500 msec. The spike frequency in the discharge was 120–250/sec. Unit responses consisting of spikes with a latent period of under 1.3 msec and, it is assumed, some of the responses with a latent period of under 4.0 msec were antidromic. The axons of some R and VA neurons were shown to form branches terminating in different zones of the orbitofrontal cortex. 相似文献
10.
The evoked potential (EP) and the pulse activity of single auditory cortex neurons were recorded simultaneously in response to a click and to a tone for cats under nembutal and nembutal — chloralose anesthesia. Both extra- and intracellular taps were employed. The experiments showed that the reaction of auditory cortex neurons in response to a click lasts from 200 to 300 msec. It consists of pulse discharges from several groups of neurons. Out of 174 neurons observed 8 responded within 4 to 7 msec after a click (before the EP). One hundred and nine neurons reacted in the range from 7 to 25 msec which coincided with the initial electropositivity of the EP; 11 neurons were in the range from 40 to 100 msec and 4 were between 180 and 270 msec. Such a sequence of involvement of different neuron groups in the reaction is probably accounted for to a large extent by the time dispersion of the afferent volley. With an intracellular tap slow alterations of membrane potential were observed in the form of an EPSP with pulses together with subsequent hyperpolarization lasting 50 to 70 msec and slowly increasing depolarization that reached a maximum after 170 to 200 msec.A. A. Bogomolets Institute of Physiology, Academy of Sciences of the Ukrainian SSR, Kiev. Translated from Neirofiziologiya, Vol. 1, No. 2, pp. 147–157, September–October, 1969. 相似文献
11.
Newly weaned rats which had been kept in the darl from birth were injected intraventricularly with (6-14C) orotic acid. Experimental rats were exposed to light for 2 h and dark controls were returned to the dark environment for 2 h. It was found that after this period the relative specific activity of the RNA in the visual cortex of the former was significantly (p<0.001) higher than that of the RNA in the visual cortex of the latter. There was no significant difference in the labelling of the frontal cortex.In a second group of experiments light deprived newly weaned rats were exposed to light for periods ranging from 0–15 h prior to being given a 1 h pulse of (6-14C) orotic acid. After 1–2 h after first exposure to light the labelling of the RNA in the visual cortex was significantly increased (p<0.001) but after 3 h the labelling was not significantly different from the dark control value. This transient increase in RNA labelling after first exposure to light was not found in the frontal cortex. 相似文献
12.
A group of functional characteristics of 103 neurons in visual cortical area 17 was investigated in acute experiments on curarized, light-adapted cats during a change in various parameters of the local photic stimuli. The average threshold sensitivity of the neuron population was 32 dB (0.052 nit), the sharpness of orientation tuning was 37°, the critical summation time was 57 msec, and the reactivity recovery time 190 msec. Photic sensitivity was lower during light adaptation than during dark adaptation, orientation selectivity of the neurons was increased, temporal summation was lengthened, and the time required by the neuron to recovery from after-inhibition was shortened. Several properties of the cortical neurons depended on the accentricity of their receptive fields: Cells with centrally localized receptive fields on average had lower thresholds and shorter summation time and they recovered their reactivity more quickly; their activity was of a higher frequency and they more often generated short phasic discharges than neurons with receptive fields in the peripheral part of the visual field. The mechanisms responsible for changes in the properties of neurons in the central and peripheral visual channels during dark and light adaptation are discussed. The presence of several inhibitory subsystems in the cortex regulating unit activity in the primary visual projection area is postulated. 相似文献
13.
《Electronic Notes in Theoretical Computer Science》1987,68(2):153-156
Determination of clinically significant temporal changes in P100 latency requires knowledge of the degree of normal intraindividual variability. Checkerboard visual evoked potentials using 3 check sizes (17′, 35′ and 70′) were performed serially on 20 healthy volunteers. Each subject was tested at least twice an average of 6 months apart. The P100 latency was measured at Oz with a forehead reference (Pz, O1 and O2 channels were also recorded). The overall average P100 latency change between studies for all check sizes and both eyes was 2.9 msec. However, the maximum absolute latency change was 11 msec. There was no significant difference between the average latency change for the 3 check sizes. The P100 interocular difference changed a mean of 2.5 msec (maximum 9 msec). Amplitude was more variable, with a mean change of about 1.5 μV or 25% (maximum was a 60% decrease in amplitude). A P100 latency change of up to at least 11 msec needs to be acknowledged as normal when assessing the clinical significance of changes in P100 latencies in patients. Also, P100 latency changes greater than 11 or 12 msec are very suggestive of an abnormality in the visual pathway. 相似文献
14.
《Electronic Notes in Theoretical Computer Science》1990,77(3):225-232
Wave VI (8.4 msec) of the brain-stem auditory evoked potential (BAEP) was maximal in a discrete region of primary auditory cortex (AI) of the anesthetized cat. Wave VI underwent rapid amplitude decreas over millimeter distances in the AI region and followed high stimulation rates. Wave VI did not show intracortical polarity inversion nor was it abolished by epicortical or intracortical GABA administration. The data are compatible with a wave VI source in the terminal axons of the thalamo-cortical radiations.Middle latency auditory responses (MAEPs) generated 10–40 msec after auditory stimulation were also recorded in a circumscribed area of AI. In contrast to wave VI, these primary auditory cortex potentials (Pa 18.3 msec; Nb 31.9 msec) underwent transcortical polarity inversion, correlated with intracortical multi-unit activity in the AI region and were reversibly altered or abolished by epicortical or intracortical GABA adminstration to the AI region. The data suggest that the Pa and Nb components of the cat MAEP are intracortically generated by neuronal elements in the AI region. 相似文献
15.
《Electronic Notes in Theoretical Computer Science》1994,92(5):373-391
The dipole source localization method was used to determine which of the brain areas known to be involved in somatosensation are the best candidate generators of the somatosensory evoked potential evoked by sural nerve stimulation. The ipsilateral central negativity and contralateral frontal positivity which occurred between 58 and 90 msec post stimulus (stable period 1) were best represented by a single source located in the primary somatosensory cortex (SI). The symmetrical central negativity and bilateral frontal positivity which occurred between 92 and 120 msec post stimulus (stable period 2) was best represented by 3 sources. One of these sources was located in SI and the other 2 were located bilaterally in either the frontal operculum or near the second somatosensory cortex (SII). The widespread negativity whose minimum was located in the contralateral fronto-temporal region and which occurred between 135 and 157 msec post stimulus (stable period 3) was also best represented by 3 sources. Two of these sources may be located bilaterally in the hippocampus. We cannot, however, eliminate the possibility that multiple sources in the cortex overlying the hippocampus (e.g., SII and frontal cortex) are responsible for these potentials. At innocuous stimulus levels the third source for stable period 3 was located near the vertex, possibly involving the supplementary motor cortex, whereas at noxious levels this source appears to be located in the cingulate cortex. We were unable to achieve any convincing source localization for the widespread positivity which occurred between 178 and 339 msec post stimulus (stable periods 4–6). Available evidence suggests that more sources were active during this interval than the three we could reliably test under these conditions. 相似文献
16.
《Electronic Notes in Theoretical Computer Science》1988,71(2):89-99
Flash and pattern reversal visual evoked potentials were recorded in awake patients undergoing stereotactic procedures for severe dyskinetic disorders resistant to medical treatment. The nucleus ventralis lateralis thalami was reached via an occipital approach. VEPs were recorded on the scalp at the entracce of the intracerebral electrode, and serially from sites at different depths. A polarity reversal of the surface recorded wave form took place as the intracerebral electrode was advanced beneath the surface cortical layers. As concerns F-VEPs, most of the scalp activity mirrored the potentials recorded down to the depth of 70-65 mm from the thalamus. The largest amplitude of intracerebral F-VEPs was obtained from recording sites at 50–70 mm from the thalamus, i.e., in the depth of the calcarine fissure. A negative wave, peaking around 47–50 msec, became evident in recording sites at 30–40 mm from the thalamus but vanished as the electrode was advanced farther. In only one patient could we record a small negative wave, peaking at 33 msec, in the vicinity of the corpus geniculatum externum. Furthermore, the oscillatory activity recorded from the scalp appeared to be generated in the cortical layers. PR-VEPs also underwent polarity reversal as the electrode traversed the cortex. PR-VEPs disappeared more superficially than F-VEPs. No PR-evoked activity could be recorded in the vicinity of the corpus geniculatum externum.We conclude that slow and fast components of VEPs recorded from the scalp are entirely generated in cortical layers. 相似文献
17.
《Electronic Notes in Theoretical Computer Science》1990,77(1):6-18
We recorded middle-latency (20–70 msec) auditory evoked potentials (MLAEPs) to monaural and binaural clicks in 30 normal adults (ages 20–49 years) at 32 scalp locations all referred to a balanced non-cephalic reference. Our goal was to define the MLAEP components that were present at comparable latencies and comparable locations across the subject population. Group and individual data were evaluated both as topographic maps and as MLAEPs at selected electrode locations.Three major components occurred between 20 and 70 msec, two well-known peaks centered at the vertex, and one previously undefined peak focused over the posterior temporal area. Pa is a 29 msec positive peak centered at the vertex and present with both monaural and binaural stimulation, Pb is a 53 msec positive peak also centered at the vertex but seen consistently only with binaural and right ear stimulation. TP41 is a 41 msec positive peak focused over both temporal areas. TP41 has not been identified in previous MLAEP studies that concentrated on central scalp locations and/or used active reference electrode sites such as ears or mastoids.Available topographic, intracranial, pharmacologic, and lesion studies indicate that Pa, Pb and TP41 are of neural origin. Whether Pa and/or Pb are produced in Heschl's gyrus, primary auditory cortex, remains unclear. TP41 is probably produced by auditory cortex on the posterior lateral surface of the temporal lobe. It should prove of considerable value in experimental and clinical evaluation of higher level auditory function in particular and of cortical function in general. 相似文献
18.
A nine-day acoustic and visual survey was conducted off the West Indies in March 1994 to study the pulse trains that were detected on SOSUS arrays throughout winter in deep water between the West Indies and Bermuda. During the survey, pulse train sounds were consistently recorded in an area 190–350 km northeast of Puerto Rico. Vocalizing animals were never visually observed, but visual sighting conditions were often poor and observation height was low. Pulse trains occurred in two basic forms. The "speed-up" pulse train was characterized by an accelerating series of pulses with energy in the 200–400 Hz band, with individual pulses lasting 40-60 msec. Speedup pulse trains started with average pulse rates of 1.5 pulses/sec, lasted 43.7 ± 6.0 sec, and ended with average pulse rates of 2.8 pulses/sec. The less common "slow-down" pulse train was characterized by a decelerating series of pulses with energy in the 250-350 Hz band. Slow-down pulse trains started at pulse rates averaging 4.5 pulses/sec, lasted 60.9 ± 5.8 sec, and ended with average pulse rates of 2.9 pulses/sec. We believe the recorded pulse trains are from minke whales based on careful reanalysis of, and comparison to, minke whale pulse-train sounds recorded in the Caribbean by Winn and Perkins (1976). 相似文献
19.
A. V. Nemtsov 《Neurophysiology》1979,11(4):226-233
Spontaneous unit activity in the visual cortex and its changes during stimulation by continuous light or flashes were investigated in waking rabbits. The study of distributions of adjacent intervals showed that the neurons differ in the ratio of burst (fast, with intervals of up to 15–40 msec) and nonburst (slow) activity and in the character of changes from one type of activity to the other. Of the total number of spikes 63% were outside bursts; the ratio of their number to the number of spikes within bursts consisting of two or of three or more spikes was 27:3:1. The relative stability of the burst structure of spontaneous activity and the limited number of spikes in them (on average 2.4) were demonstrated. Bursts of three or more spikes (mean 3.6) were irregular, and in 79% of them a longer interval (18.6±2.4 msec) was observed before the shortest interval (7.9±0.9 msec). Bursts of spikes of most neurons during photic stimulation contain more spikes with shorter intervals; they also began more frequently with the shortest interval, possibly signifying an increase in the steepness and amplitude of the EPSPs lying at their basis. However, in 20% of neurons spontaneous bursts included more spikes and with shorter intervals than bursts evoked by flash stimulation.Research Institute of Psychiatry, Ministry of Health of the RSFSR, Moscow. Translated from Neirofiziologiya, Vol. 11, No. 4, pp. 311–320, July–August, 1979. 相似文献
20.
In cats anesthetized with chloralose and pentobarbital and immobilized with D-tubocurarine activity of 423 pericruciate cortical neurons was recorded (342 extra- and 81 intracellularly); 78 neurons had spontaneous activity. Stimulation of the pyramidal tract evoked antidromic action potentials in the pyramidal neurons with a latent period of 0.5–16.0 msec. Recurrent and lateral PSPs also developed both in pyramidal and in unidentified neurons in all layers of the cortex; IPSPs were recorded in 46.7% of neurons, EPSPs in 21.0%, mixed reponses in 26.0%, and no visible changes were found in 6.3%. The latent period of the IPSPs was 1.5–14.0 msec, their amplitude 1.3–17.0 mV, their rise time from 4 to 18 msec, and their duration 18–120 msec (sometimes up to 250–500 msec). In 30% of cases in which IPSPs appeared, their course was divided into two phases: fast (duration 10–20 msec) and slow. EPSPs developed after a latent period of 2.6–29.0 msec; their amplitude was 1.0–7.8 mV and their duration from 10.0 to 50.0 msec. In 51.2% of spontaneously active neurons the antidromic volley inhibited their activity in the course of 200–400 msec, in 19.5% it stimulated their activity, in 7.4% it had a mixed effect, and in 21.9% no visible change took place in their activity. The role and participation of axon collaterals of pyramidal neurons and of the interneuronal system in the formation of these processes are discussed. 相似文献