共查询到20条相似文献,搜索用时 31 毫秒
1.
2.
J E Feagin 《The Journal of biological chemistry》1990,265(32):19373-19376
3.
4.
G S Groot N van Harten-Loosbroek G J van Ommen H L Pijst 《Nucleic acids research》1981,9(23):6369-6377
5.
RNA editing site recognition in higher plant mitochondria. 总被引:4,自引:0,他引:4
6.
7.
8.
9.
《Seminars in cell biology》1993,4(4):279-284
RNA editing in plant mitochondria alters nearly all mRNAs by C to U and U to C transitions. In some species more than 400 edited sites have been identified with significant effects on the encoded proteins. RNA editing occurs in higher and lower plants and presumably has evolved before the differentiation of land plants. Current research focuses on the elucidation of the biochemistry and the specificity determinants of RNA editing in plant mitochrondria. 相似文献
10.
11.
12.
Schneider A 《Trends in cell biology》1994,4(8):282-286
RNAs that function in mitochondria, in contrast to the majority of mitochondrial proteins, are generally encoded by the mitochondrial genome. However, evidence has been presented for transport of nucleus-encoded tRNAs into mitochondria in diverse organisms. While mitochondrial protein import has been characterized in great detail, virtually nothing is known about the pathway of RNA import into mitochondria. Only very recently have in vivo systems for RNA import been established, and these are now providing some insight into this intriguing process. 相似文献
13.
14.
15.
16.
17.
18.
19.
Accurate and efficient insertional RNA editing in isolated Physarum mitochondria. 总被引:2,自引:2,他引:0
下载免费PDF全文
![点击此处可从《RNA (New York, N.Y.)》网站下载免费的PDF全文](/ch/ext_images/free.gif)
RNA editing is a process whereby nucleotide insertion, deletion, or base substitution results in the production of an RNA whose sequence differs from that of its template. The mitochondrial RNAs of Physarum polycephalum are processed specifically at multiple sites by both mono- and dinucleotide insertions, as well as apparent cytidine (C) to uridine (U) changes. The precise mechanism and timing of these processing events are currently unknown. We describe here the development of an isolated mitochondrial system in which exogenously supplied nucleotides can be incorporated into RNAs under defined conditions. The results of S1 nuclease protection, nearest neighbor and RNase T1 fingerprint analyses indicate that the vast majority of these newly synthesized mitochondrial RNAs have been accurately and efficiently processed by both mono- and dinucleotide insertions. This work provides a direct demonstration of faithful nucleotide insertion in a mitochondrial editing system. In contrast, the newly synthesized RNAs are not processed by C to U changes in the isolated mitochondria, suggesting that the base changes observed in Physarum are unlikely to occur via a deletion/insertion mechanism. 相似文献
20.