共查询到20条相似文献,搜索用时 15 毫秒
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Yeh M Gharavi NM Choi J Hsieh X Reed E Mouillesseaux KP Cole AL Reddy ST Berliner JA 《The Journal of biological chemistry》2004,279(29):30175-30181
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Yanagisawa M Nakashima K Arakawa H Ikenaka K Yoshida K Kishimoto T Hisatsune T Taga T 《Journal of neurochemistry》2000,74(4):1498-1504
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Interleukin-15 prevents mouse mast cell apoptosis through STAT6-mediated Bcl-xL expression 总被引:5,自引:0,他引:5
Masuda A Matsuguchi T Yamaki K Hayakawa T Yoshikai Y 《The Journal of biological chemistry》2001,276(28):26107-26113
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cAMP-induced astrocytic differentiation of C6 glioma cells is mediated by autocrine interleukin-6 总被引:6,自引:0,他引:6
Takanaga H Yoshitake T Hara S Yamasaki C Kunimoto M 《The Journal of biological chemistry》2004,279(15):15441-15447
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Ly-6A/E induction by interleukin-6 and interleukin-9 in T cells 总被引:1,自引:0,他引:1
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Signal transducer and activator of transcription 3 is required for glycoprotein 130-mediated induction of vascular endothelial growth factor in cardiac myocytes 总被引:11,自引:0,他引:11
Funamoto M Fujio Y Kunisada K Negoro S Tone E Osugi T Hirota H Izumi M Yoshizaki K Walsh K Kishimoto T Yamauchi-Takihara K 《The Journal of biological chemistry》2000,275(14):10561-10566
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Akira Yamasaki Ali Saleh Latifa Koussih Shigeo Muro Andrew J. Halayko Abdelilah S. Gounni 《PloS one》2010,5(2)
Background
Previous findings support the concept that IL-9 may play a significant role in mediating both pro-inflammatory and changes in airway responsiveness that characterizes the atopic asthmatic state. We previously demonstrated that human airway smooth muscle (ASM) cells express a functional IL-9R that mediate CCL11 expression. However, the signaling pathway governing this effect is not well understood.Methodology/Principal Findings
In this study, we showed that IL-9 mediated CCL11 expression in ASM cells does not rely on STAT6 or STAT5 but on STAT3 pathway. IL-9 induced rapid STAT3 activation in primary ASM cells that was not observed in case of STAT6 or STAT5. STAT3 binding to CCL11 promoter was also observed in vivo upon IL-9 stimulation of ASM cells. Disruption of STAT3 activity with SH2 domain binding inhibitory peptide results in significant reduction of IL-9 mediated CCL11 promoter activity. DN STAT3β over-expression in ASM cells, but not Ser 727 STAT3 or STAT6 DN, abolishes IL-9 mediated CCL11 promoter activity. Finally, STAT3 but not STAT6 silenced ASM cells showed significant reduction in IL-9 mediated CCL11 promoter activity and mRNA expression.Conclusion/Significance
Taken together, our results indicate that IL-9 mediated CCL11 via STAT3 signalling pathway may play a crucial role in airway inflammatory responses. 相似文献18.
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