Intento de Aislamiento del Paracoccidioides brasiliensis del suelo

Resumen Cuarenta y cinco muestras de tierra, preferentemente de cafetales a más de 500 m de altitud sobre el nivel del mar, de varias regiones de Venezuela fueron inoculadas por vía endovenosa en ratones.No pudo aislarse elParacoccidioides brasiliensis.Se discuten brevemente las posibles causas de los resultados negativos y se proponen otras téchnicas para seguir intentando la determinación del habitat deParacoccidioides brasiliensis.

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Summary Forty five soil samples, most of them from coffee plantations at more than 500 m altitude, from several parts from Venezuela were inoculated intravenously into mice. Paracoccidioides brasilicnsis was not isolated.The authors discuss the possible reasons of the negative results and propose other techniques to apply in the future in order to isolateParacoccidioides brasilicnsis from nature.

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Résumé Quarante cinq échantillons de terre furent inoculés par voie intravéneuse — des souris. Les échantillons provenaient principalement de plantations de café — plus de 500 m d'altitude de plusieurs régions du Venezuela.LeParacoccidioides brasiliensis n'a pu etre isolé.Les auteurs discutent les causes éventuelles de cet échec et proposent des méthodes différentes pour reprendre la recherche duParacoccidioides brasiliensis dans la nature.

     

La medición de la dependencia a partir del tiempo de cuidado y del baremo de valoración de dependencia

AimsTo assign care time to the activities collected in the Dependency Assessment Scale (BVD) and to analyse the relationship between care time and the score received on the BVD.MethodsA cross-sectional observational study of 148 dependent persons was carried out. Socioeconomic and clinical data, the BVD, the 6-dimensional dependency indicator (DEP-6D), as well as data from a diary with the time of care received, were collected. The median time needed to carry out the activities included in the BVD was estimated from the diary. Following the BVD methodology, those who had their mental functions affected were separated. Each person was assigned two scores, one based on BVD and the other based on the time that the caregivers spent to care for them. The correlation between the two was estimated, and a regression was performed to identify the main explanatory factors for the disparity between the two indicators.ResultsBVD and hours of care show a moderate positive correlation. The mental impairment of the dependent person increased the time of care in most activities. The regression analysis suggests that while mental impairment is the main explanatory factor of obtaining a higher assessment with care time than with BVD, being bedridden is the main predictor of having a higher sore with the BVD.ConclusionsThe construct that underlies BVD is moderately related to care time. Future research must contrast the robustness of these results and address whether the normative criteria that underlie the BVD is aligned with the weights that characterise it.     

Enfermedad de Alzheimer y calidad de vida del cuidador informal

Background

Along with an ageing population, a higher incidence of chronic diseases leads to increasingly complex health profiles. The relationship between survival, dependence, and social and demographic trends affecting caregiving, has led to an increase in the negative consequences associated with care provision. In this context, an assessment needs to be made on the impact that caregiving has on the well-being of the caregivers. The main aim of this article is to study the factors that determine the Quality of Life (QoL) of those who provide informal care to people suffering from Alzheimer's disease (AD).

Examen de personas histoplasmino-positivas del radio de actividad del hospital amazónico „Albert Schweitzer” en el curso medio del rio Ucayali

Resumen 1) Se analizan las historias clínicas de 100 personas histoplasmino-positivas. 61% de ellas son histoplasmino-positivas y tuberculinonegativas, 39% histoplasmino y tuberculino-positivas.2) Se habían sacado radiografías de los pulmones a 38 de los 100 pacientes, encontrándose calcificaciones en 22, sea en un 58% de ellos.3) Se describen 4 casos: 3 de ellos con una historia y con signos radiológicos que hacen evidente que han tenido una histoplasmosis; un caso es consideredo como una histoplasmosis en evolución.4) En todos los casos se trata de formas benignas de histoplasmosis.

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Summary 1) Analysis of the clinical histories of 100 histoplasmin-positive reactors: 61% are histoplasmin-positive and tuberculin-negative, 39% histoplasmin- and tuberculin-positive.2) Lung X-rays have been taken of 38 of the 100 patients. In 22 X-rays (58%) calcifications are present.3) 4 cases are described: 3 of them with a history and with radiological symptoms, that make it evident, that they have had a histoplasmosis; one case is considered as a histoplasmosis in evolution.4) All cases are benign forms of histoplasmosis.

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Zusammenfassung 1) Die Krankengeschichten von 100 histoplasmin-positiven Patienten werden analysiert. 61% davon sind histoplasmin-positiv und tuberkulin-negativ, 39% histoplasmin- und tuberkulin-positiv.2) Von 38 der 100 Patienten wurden Lungenroentgenbilder aufgenommen. In 22 Aufnahmen (58%) fanden sich Verkalkungen.3) 4 Fälle werden beschrieben: bei dreien machen es Krankengeschichte und Roentgenbefund evident, dass sie eine Histoplasmose durchgemacht haben; ein Fall wird als akute Histoplasmose angesehen.4) Bei allen Fällen handelt es sich um eine gutartige Form der Histoplasmose.

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Read in the meeting of the First Congress of the International Society for Tropical Dermatology, Naples, June 8–13, 1964.     

Significado del dimorfismo de ciertos hongos parasitos

Author thinks that dimorphism of certain pathogenic fungi (e.g.,Coccidioides immitis, Blastomyces dermatitidis, Histoplasma capsulatum, Paracoccidioides brasiliensis, Sporotrichum schenckii), as it is currently known, is a biological nonsense. He postulates the existance, in the extra-human life of these species, of unknown circumstances under which dimorphism would be a useful and (perhaps) necessary mechanism for surviving and thriving.     

Abordaje del anciano en el servicio de urgencias de un hospital de agudos

Elderly people use often and in an appropriate way the Emergency Department (ED). However, we don’t dispose of evidences that demonstrate utility of a specific model of geriatric assessment (GA) applied in ED. Nowadays; GA in ED should be used being adapted to the environment and with some clear objectives that allow to carry out a multidimensional diagnosis and to establish therapeutic priorities. GA contributes benefits in the continuity of care on the part of the Primary Attention when elderly people are discharged from an ED.     

Actividad del sistema neuronal LHRH en un modelo animal de retraso del crecimiento

ObjectiveMild and chronic energy restriction results in growth retardation with puberal delay, a nutritional disease known as nutritional dwarfing (ND). The aim of the present study was to assess the profile of hypothalamic luteinizing hormone-releasing hormone (LHRH) release, at baseline and under glutamate stimulation, in ND rats to elucidate gonadotrophic dysfunction. Reproductive ability during refeeding was also studied.Material and methodsAt weaning, 60 male rats were assigned to two groups of 30 animals each: a control and an experimental group. Control rats were fed ad libitum with a balanced rodent diet. The experimental group received 80% of the diet consumed by the control group for 4 weeks. After 4 weeks of food restriction, the ND group was fed freely for 8 weeks. Ten rats from each group were sacrificed every 4 weeks for assays.ResultsAt week 4, body weight and length were significantly diminished in the experimental group vs. the control group (p<0.001). No changes were observed in LHRH baseline release, pulse frequency or amplitude in the experimental group compared with the control group at any time. However, under glutamate stimulation, LHRH release was significantly higher in ND rats than in control rats at week 4 (p<0.05). Refeeding the ND group allowed the rats to reach overall growth and reproductive ability.ConclusionsThe results of the present study suggest that the response to the facilitatory effect of glutamate on LHRH release in post-restricted ND rats is probably related to a lesser central nervous system maturation in relation to their chronological age. The adequate somatic growth and normal reproductive ability attained with refeeding suggest the reversibility of the two energetically costly processes compromised by global, mild and chronic food restriction.     

Aislamiento de keratinomyces ajelloi y microsporum gypseum del suelo de la ciudad de buenos aires

Summary Keratinomyces ajelloi andMicrosporum gypseum have been isolated from soil samples from public gardens and from a breeding-place with rabbits and fowls in the urban zone of the Buenos Aires city, usingVanbreuseghem's technique with hair bait.On the Petri dishes with soil and hair the characteristic cleistotecia of the sexual form were observed.     

Pronóstico del paciente tratado de síndrome de Cushing

Cushing syndrome (CS), due to an ACTH-secreting pituitary adenoma, adrenal tumors, or ectopic ACTH secretion, causes hypercortisolism. CS is associated with major morbidity, especially metabolic and cardiovascular complications, osteoporosis, psychiatric changes, and cognitive impairment. Despite biochemical “cure” of hypercortisolism and clinical improvement after effective treatment, these complications are only partially reversible. Exacerbation of prior autoimmune diseases is also seen. All of these lead to quality of life impairment and increased mortality. This review addresses the main comorbidities and long-term consequences of CS despite clinical and biochemical “cure”.     

Produccion de esferulas endosporuladas por inoculacion de hongos artroconidiosporados aislados del suelo

With several fungi isolated from samples of soils obtained in the province of San Luis and in the province of Mendoza (Argentina), we employed a simple technique for the inoculation in the mice's foot in order to provoke the formation of endosporulated spherules.As a conclusion, it could be proved that all these strains classificated as Gimnoascaceae, genus Malbranchea sp. and Auxarthron zuffianum, produce what appear to be endosporulating spherules. The viability of the endospores was not demonstrated nor was disseminating infection produced.