Optogenetic stimulation of serotonin nuclei retrieve the lost memory in Alzheimer's disease

How are memories stored and retrieved? It was one of the most discussed questions in the past century by neuroscientists. Leading studies of the period brought two different explanations to this question: The first statement considers memory as a physiological change in the brain and suggest that the retrieval of memory is only occurred by the same physiologic changes observed during the memory formation, while the second suggests that memory is a psychic mood stored in mind and the retrieval of memory is occurred by mystical energy fluctuations. Although the exact reason and the pathogenesis of Alzheimer's disease have not yet been fully understood, the approaches that centered the retrieval strategy of lost memory constitutes the basis of the treatment strategies in Alzheimer's disease today. The majority of treatment studies has based on the manipulation of the cholinergic system; however, although serotonin has mnemonic effects, its role in the pathogenesis of Alzheimer's disease has not been investigated as much as the cholinergic system. Here we show how serotonin affects the pathogenesis of Alzheimer's disease in a comprehensive perspective and we suggest that the optogenetics manipulation of serotonin nuclei retrieve the lost memory by closing the inward-rectifier potassium channel Kir2 on the memory engram cells. Also, we raise the possible effects of serotonin on the memory engram cells and the interactions between the amyloid-centric hypothesis of Alzheimer's disease and the memory engram hypothesis to explain the pathophysiology of memory loss in Alzheimer's disease.     

Rendering the absent visible: victimhood and the irreconcilability of violence

Contemporary justice-making processes often focus on reconciliation or legal retribution, but not on the complexity of victimhood beyond individual subjectivity or refusals of state propositions for social repair. In Colombia, where drug cartels and state-sponsored violence had terrorized the population for over fifty years, it was not forgiveness and acceptance that punctuated the turn of the twenty-first century, but the refusal to reconcile with the state's duplicity regarding the disappearance and death of thousands. This essay illustrates how irreconciliation as an affective sentiment is taking shape in Colombia through forms of reattribution that take the form of victim visibilizations. In analysing the strategic use of victim visibilizations as a refusal of state accountability, their expansion of the notion of victimhood, and their politics of irreconciliation, I show how even with the state's remorse-driven discourses, the public's understanding that political, judicial, and social accountability was not possible and pushed them to chart new strategies for disclosure and healing.     

‘A genealogist's paradise’: France,Québec and the genealogics of race

Genealogy, or the study of one's ancestral patri-lineage, has a long and esteemed pedigree in French Canadian and Québécois history. From Cyprien Tanguay's late-nineteenth-century encyclopedias to René Jetté's updated versions more than a century later, genealogy has been an important component of French Canadian nationalisms. Tracing one's ancestry back to the early St. Lawrence settlement in the seventeenth century has provided Québécois subjects with opportune political and social capital with which to make territorial and national claims legitimate. Through a case study approach, I explain how genealogy provides the grounds upon which Québécois and French subjects remember a shared past. Specifically, I examine a variety of sites of memory in the French countryside, including a museum that relies on ‘genealogics’ to call the French Canadian Québécois back to its roots. As such, I demonstrate how the biological, read as a contemporary articulation of Balibar's notion of the racial supplément necessary to nation building, travels across the Atlantic.     

Senegalese immigrant families’ ‘regroupement’ in France and the im/possibility of reconstituting family across multiple temporalities and spatialities

This paper interrogates the structural conditions, macropolitics and governmentality of family ‘regroupement’ in France in an era of shifting immigration policies in Europe and the imaginative possibilities that Senegalese immigrants exercise to maintain family and kinship ties with those left behind. It argues that while the need to maintain ties from diasporic locations is mediated by policies, material and emotive transnational practices, the materiality of displacement as well as the state's politics of immigration render more elusive possibilities of maintaining family in situ. What tensions and creative strategies emerge? How is ‘home’, the primordial site of family structure, reimagined and reconstituted? Taking into account state's politics and immigrants’ entrapment within multiple spheres of power and their active agency as determinants, this paper uncovers how displacement gives rise to multiple ruptures while simultaneously motivating a search for active agency to reconstruct and reimagine kinship, family and conjugality across multiple temporalities and spatialities.     

Some characteristics of spatial associative memory in the pigeon, Columba livia

Willson and Wilkie (1993) developed a novel procedure to assess pigeons' memory for the spatial location of food. Only one of four locations provided food each daily session. Each location consisted of an illuminated pecking key and grain feeder. Over different days different locations, randomly selected, provided food during a 16-min session. The pigeons tended to revisit the location at which food was found on the previous day thereby demonstrating memory for food-spatial location associations over 24 h. Three experiments were conducted to further investigate this phenomenon. In Experiment 1 the session duration was varied between 4 and 32 min. Longer sessions had no detectable effect on their ability to remember the rewarded location 24 h later, a result that suggests that only brief encounters with food at a particular location are necessary for recall. In Experiment 2 the necessity of an active search for the day's rewarded location was removed; a 5-min period in which only the rewarded key was lit preceded the regular 16-min session. Pecks to the lit key in this 5-min period produced grain on the standard schedule. This manipulation facilitated the pigeons' discovery of food but did not affect their ability to remember the rewarded location, suggesting that the process of search and discovery is not essential to the associative memory process. In Experiment 3, food was available during the complete session (non-depleting condition) or was available only during the first half of the session (depleting condition). No detectable differences in the birds' memory of yesterday's profitable location were found. This suggests that non-depletion of food is not a necessary condition for day-to-day recall of food location. Taken together these findings enlarge our understanding of the spatial associative memory process.     

Social context hinders humans but not ravens in a short-term memory task

Using resources shared within a social group—either in a cooperative or a competitive way—requires keeping track of own and others’ actions, which, in turn, requires well-developed short-term memory. Although short-term memory has been tested in social mammal species, little is known about this capacity in highly social birds, such as ravens. We compared ravens (Corvus corax) with humans in spatial tasks based on caching, which required short-term memory of one's own and of others’ actions. Human short-term memory has been most extensively tested of all social mammal species, hence providing an informative benchmark for the ravens. A recent study on another corvid species (Corvus corone) suggests their capacity to be similar to the humans’, but short-term memory skills have, to date, not been compared in a social setting. We used spatial setups based on caches of foods or objects, divided into individual and social conditions with two different spatial arrangements of caches (in a row or a 3 × 3 matrix). In each trial, a set of three up to nine caches was presented to an individual that was thereafter allowed to retrieve all items. Humans performed better on average across trials, but their performance dropped, when they had to keep track of partner's actions. This differed in ravens, as keeping track of such actions did not impair their performance. However, both humans and ravens demonstrated more memory-related mistakes in the social than in the individual conditions. Therefore, whereas both the ravens’ and the humans’ memory suffered in the social conditions, the ravens seemed to deal better with the demands of these conditions. The social conditions had a competitive element, and one might speculate that ravens’ memory strategies are more attuned to such situations, in particular in caching contexts, than is the case for humans.     

Being from the Land: Memory,Self and the Power of Place in Indigenous Southern Chile

Connection with ancestral land is a central tenet of indigenous identity claims. In a departure from constructivist approaches to the role ancestral land in identity politics, this article focuses on the discursive and experiential manifestations of Mapuche theories of emplacement, according to which land is actively involved in the making of selves. By drawing upon the notion of tuwün, a term roughly translatable as place of origin, I argue that ancestral land acts as a potentiality of selfhood through the articulation of sameness and otherness within Mapuche society and with canonical others (winka). The ethnographic analysis of the relation between landscape and memory will illustrate how ancestral land works to situate the present between two poles of alterity, namely past dwellers and winka. Such a focus allows us to acknowledge the significance of ancestral land without resorting to genealogical and essentialist interpretations of indigenous subjectivity.     

Elements of episodic-like memory in animal models

Representations of unique events from one’s past constitute the content of episodic memories. A number of studies with non-human animals have revealed that animals remember specific episodes from their past (referred to as episodic-like memory). The development of animal models of memory holds enormous potential for gaining insight into the biological bases of human memory. Specifically, given the extensive knowledge of the rodent brain, the development of rodent models of episodic memory would open new opportunities to explore the neuroanatomical, neurochemical, neurophysiological, and molecular mechanisms of memory. Development of such animal models holds enormous potential for studying functional changes in episodic memory in animal models of Alzheimer’s disease, amnesia, and other human memory pathologies. This article reviews several approaches that have been used to assess episodic-like memory in animals. The approaches reviewed include the discrimination of what, where, and when in a radial arm maze, dissociation of recollection and familiarity, object recognition, binding, unexpected questions, and anticipation of a reproductive state. The diversity of approaches may promote the development of converging lines of evidence on the difficult problem of assessing episodic-like memory in animals.     

Universalizing the Law of the Sea in the South China Sea Dispute

This article argues that a resolution of the maritime disputes in the South China Sea must be based upon a universalist framework where the maritime interests of the world are upheld. The article discusses the universalist framework of the 1982 United Nations Convention on the Law of the Sea (UNCLOS) and the universalist approach taken by the Tribunal on 12 July 2016 in the South China Sea Arbitration regarding the extinguishment of a state's “exceptionalist” maritime claims and the adoption of strict criteria for the characterization of features at sea.     

Contemporary Chinese TV Serials: Configuring Collective Memory of Socialist Nostalgia via the Cultural Revolution

Using China's Cultural Revolution as a representative historical event, this article examines how the collective memory and popular history revolving around it are manufactured and interpreted in televisual media narratives. The collective memory of the Cultural Revolution, as I will show, is constructed and not preserved, and the collective framework of memory, as the predominant thoughts and the governing ideological rhetoric of society, configures people's memories of past events. A textual analysis of the TV drama, The Place Where Dreams Start [Meng kaishi de difang, 1998], a typical revolutionary nostalgia text, will expose the process of collective memory concerning the Cultural Revolution for what it is—cultural amnesia that is misleading and regressive.     

Chromatographic enantioseparation by poly(biphenylylacetylene) derivatives with memory of both axial chirality and macromolecular helicity

Novel poly(biphenylylacetylene) derivatives bearing two acetyloxy groups at the 2‐ and 2′‐positions and an alkoxycarbonyl group at the 4′‐position of the biphenyl pendants (poly‐ Ac 's) were synthesized by the polymerization of the corresponding biphenylylacetylenes using a rhodium catalyst. The obtained stereoregular (cis ‐transoidal ) poly‐ Ac 's folded into a predominantly one‐handed helical conformation accompanied by a preferred‐handed axially twisted conformation of the biphenyl pendants through noncovalent interactions with a chiral alcohol and both the induced main‐chain helicity and the pendant axial chirality were maintained, that is, memorized, after complete removal of the chiral alcohol. The stability of the helicity memory of the poly‐ Ac 's in a solution was lower than that of the analogous poly(biphenylylacetylene)s bearing two methoxymethoxy groups at the 2‐ and 2′‐positions of the biphenyl pendants (poly‐ MOM 's). In the solid state, however, the helicity memory of the poly‐ Ac 's was much more stable and showed a better chiral recognition ability toward several racemates than that of the previously reported poly‐ MOM when used as a chiral stationary phase for high‐performance liquid chromatography. In particular, the poly‐ Ac ‐based CSP with a helicity memory efficiently separated racemic benzoin derivatives into enantiomers.     

Contesting Patrimony: Cusco's Mystical Tourist Industry and the Politics of Incanismo

The Peruvian state's neoliberal policies include its mission to modernize Peru through international tourism and foreign investment, and tourism promoters and politicians increasingly invoke Andean mysticism and Inca patrimony (or incanismo) as a marketing strategy. This paper argues that Cusqueño citizens invoke the same representations, with competing claims of authenticity and authority, as they construct their own versions of Incanist identification in populist movements against the state and its enforcement of the global neoliberal order, as well as in their attempts to survive in the tourist economy. In Peru, criticism of the tourist industry is often grounded in incanismo and seems to take aim at the neoliberal order. However, closer analysis reveals a more complicated set of relationships between resistance and liberalism. Friction emerges not because cultural identity is being commodified or inequalities persist, but because local desires for access to the market are frustrated by state and municipal agencies.     

TIP39 modulates effects of novelty‐induced arousal on memory

Tuberoinfundibular peptide of 39 residues (TIP39) is a neuropeptide localized to neural circuits subserving emotional processing. Recent work showed that mice with null mutation for the gene coding TIP39 (TIP39‐KO mice) display increased susceptibility to environmental provocation. Based on this stressor‐dependent phenotype, the neuroanatomical distribution of TIP39, and knowledge that novelty‐induced arousal modulates memory functions via noradrenergic activation, we hypothesized that exposure to a novel environment differently affects memory performance of mice with or without TIP39 signaling, potentially by differences in sensitivity of the noradrenergic system. We tested TIP39‐KO mice and mice with null mutation of its receptor, the parathyroid hormone 2 receptor (PTH2‐R), in tasks of short‐term declarative and social memory (object recognition and social recognition tests, respectively), and of working memory (Y‐maze test) under conditions of novelty‐induced arousal or acclimation to the test conditions. Mice lacking TIP39 signaling showed memory impairment selectively under conditions of novelty‐induced arousal. Acute administration of a PTH2‐R antagonist in wild‐type mice had a similar effect. The restoration of memory functions in TIP39‐KO mice after injection of a β‐adrenoreceptor‐blocker, propranolol, suggested involvement of the noradrenergic system. Collectively, these results suggest that the TIP39/PTH2‐R system modulates the effects of novelty exposure on memory performance, potentially by acting on noradrenergic signaling.     

Sympathy and suspicion: torture,asylum, and humanity

This article examines the assessment of claims about torture in the British asylum process. It is compassion in the face of suffering that underlies much of the ethical objection to torture. Yet, at the same time, torture survivors, as with asylum seekers more broadly, are subjected to widespread suspicions about the genuineness of their claims. This article argues that the very process of imagined identification found in compassion can lie behind suspicion. Anthropology has largely treated otherness as a cause of fear and suspicion. However, the denial of another's suffering is not always about a failure to recognize mutual humanity. It can also be a product of a sense of fundamental similarity, based on assumptions about the mutual capacity to dissimulate. Ultimately, though, scepticism is on just as shaky ground as belief, as it is filtered through the lens of imagined identification. Denial is just as vicarious as acknowledgement.     

Good‐for‐nothing haya names: Powers of recollection in northwest Tanzania

This article explores names and naming practices in Haya communities of Northwest Tanzania. Certain Haya names evoke past experiences and circumstances that surround the birth of a child, as well as the social reputation of the child's parents, I argue that this act of recollection embedded in such names can best be understood as an effort to displace past reputations, and overcome the disparaging views of one's consociates. From this perspective, Haya names can be understood as modes of remembering designed to both recall and undermine past memories; as well as forms of social agency through which people actively attempt to engage in and transform their social conditions.     

The Middle East's majority problems: minoritarian regimes and the threat of democracy

This article examines the phenomenon of minoritarian regimes in the Middle East, focusing on Bahrain, Syria and Israel/Palestine. It considers, in each, how minority rule was established, the mechanisms through which it is maintained, and the means through which it is legitimated. Although these regimes are not typically analyzed as a category, they have important features in common. In all three, the state's political and security institutions are controlled by members of an ethnic/religious group that is a numerical minority in the country, at the expense of a majority group with a competing claim to indigeneity. While the legal and political mechanisms that these regimes use to restrict access to power vary, they employ similar strategies for legitimating minority rule, presenting democracy as a threat not only to the regime's survival, but also to the security of the group whose interests it claims to represent.     

Public History,Private Memory: Notes from the Ethnography of Colonial Williamsburg,Virginia, USA

Colonial Williamsburg, and U.S. history museums generally, claim to transform public history into collective memory. That is, they convey an objective documented history to the public who, absorbing that history, acquires an appropriate collective or national memory. We argue that the emphasis on consumer (visitor) experience at such museums collapses the distance between the reconstructed past (the museum's history lesson) and the visitor's touristic or familial experience at the site. Visitors indeed remember their visits to Colonial Williamsburg, but their specific memories would seem to have little to contribute to any 'collective memory' of a 'national history.'     

Melatonin and its metabolite N(1)‐acetyl‐N(1)‐formyl‐5‐methoxykynuramine improve learning and memory impairment related to Alzheimer's disease in rats

The aim of this study was to investigate the effect of melatonin (MT) and its metabolite N(1)‐acetyl‐N(2)‐formyl‐5‐methoxykynuramine (AFMK) on Alzheimer‐like learning and memory impairment in rats intracerebroventricularly injected with streptozotocin (STZ). The results showed that the escape latency of the STZ group was longer than that of the control (CON), MT, and AFMK groups. Increased levels of hyperphosphorylated tau, neurofilament proteins, and malondialdehyde and decreased superoxide dismutase levels were observed in the brains of the rats from the STZ group compared with the brains of the rats from the CON, MT, AFMK high and low group. These results suggest that exogenous MT and AFMK can improve memory impairment and downregulate AD‐like hyperphosphorylation induced by STZ, most likely through their antioxidation function. Meanwhile, we found that an equal dose of AFMK had a stronger effect than that of MT. Our results indicate that MT and its metabolite AFMK represent novel treatment strategies for Alzheimer's disease.     

Shifting perspectives on transnationalism: analysing Dutch political discourse on Moroccan migrants' transnational ties, 1960–2010

Abstract

This article examines the Dutch state's shifting perspectives on migrants' ties with their country of origin. In the academic literature transnationalism was introduced as a neutral term. In political debates the term transnationalism is hardly used, but the ties of migrants with their country of origin (to which the term transnationalism relates) are given a strong negative connotation. They are seen as the main course of failed integration policy. In the past fifty years a dramatic shift has occurred in how these ties are perceived. First, they were regarded positively and were believed to facilitate an easy return of the guest workers. Later they continued to be portrayed positively, but were also considered to be a springboard for integration into Dutch society. Recently they have been portrayed negatively and as the main obstacle to integration. This article explores why this dramatic shift in connotation has occurred.     

Language and Place-knowledge on Norfolk Island

Using the place-naming practices in the small settler society of Norfolk Island, the home of Anglo-Polynesian descendants of the Bounty mutineers, we advance a linguistic argument against Saussure's claims concerning the arbitrariness of signs. When extended to place names, Saussure's claims about language in general imply place names in themselves hold no significance for how people interact with places. In contrast, we use ethnographic examples to show that people of Norfolk Island interact with the significance of the names themselves. Arguments for an integrated approach to toponymy in which place names are considered alongside other relational (cultural, economic and historical) factors that influence their use and meaning are put forward. We propose ‘toponymic ethnography’ as a useful methodology for understanding the connectedness of toponyms to people, place, and social networks.