共查询到20条相似文献,搜索用时 15 毫秒
1.
2.
Hu C Perlmutter DH 《American journal of physiology. Lung cellular and molecular physiology》2002,282(4):L757-L765
The synergistic action of hepatocyte nuclear factor (HNF)-1alpha and HNF-4 plays an important role in expression of the alpha(1)-antitrypsin (alpha(1)-AT) gene in human hepatic and intestinal epithelial cells. Recent studies have indicated that the alpha(1)-AT gene is also expressed in human pulmonary alveolar epithelial cells, a potentially important local site of the lung antiprotease defense. In this study, we examined the possibility that alpha(1)-AT gene expression in a human pulmonary epithelial cell line H441 was also directed by the synergistic action of HNF-1alpha and HNF-4 and/or by the action of HNF-3, which has been shown to play a dominant role in gene expression in H441 cells. The results show that alpha(1)-AT gene expression in H441 cells is predominantly driven by HNF-1beta, even though HNF-1beta has no effect on alpha(1)-AT gene expression in human hepatic Hep G2 and human intestinal epithelial Caco-2 cell lines. Expression of alpha(1)-AT and HNF-1beta was also demonstrated in primary cultures of human respiratory epithelial cells. HNF-4 has no effect on alpha(1)-AT gene expression in H441 cells, even when it is cotransfected with HNF-1beta or HNF-1alpha. HNF-3 by itself has little effect on alpha(1)-AT gene expression in H441, Hep G2, or Caco-2 cells but tends to have an upregulating effect when cotransfected with HNF-1 in Hep G2 and Caco-2 cells. These results indicate the unique involvement of HNF-1beta in alpha(1)-AT gene expression in a cell line and primary cultures derived from human respiratory epithelium. 相似文献
3.
4.
SREBP-1 interacts with hepatocyte nuclear factor-4 alpha and interferes with PGC-1 recruitment to suppress hepatic gluconeogenic genes 总被引:12,自引:0,他引:12
Yamamoto T Shimano H Nakagawa Y Ide T Yahagi N Matsuzaka T Nakakuki M Takahashi A Suzuki H Sone H Toyoshima H Sato R Yamada N 《The Journal of biological chemistry》2004,279(13):12027-12035
5.
6.
7.
8.
9.
10.
11.
12.
13.
Tarumi T Kravtsov DV Zhao M Williams SM Gailani D 《The Journal of biological chemistry》2002,277(21):18510-18516
14.
15.
16.
17.
18.
19.