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伊曲康唑和特比萘芬治疗孢子丝菌病(sporo-trichosis)有效安全,目前已成为孢子丝菌病治疗指南中的推荐用药[1].但少数患者单用伊曲康唑或特比萘芬不能有效控制病情,研究显示两药分别联合碘化钾溶液或两药联合治疗皮肤型孢子丝菌病显示疗效增强2-6].最近,我们诊治1例由球形孢子丝菌引起的皮肤固定型孢子丝菌病患者,采用特比萘芬联合伊曲康唑治疗失败,之后经特比萘芬联合碘化钾溶液治疗才获得痊愈.鉴于该病例治疗过程的特殊性,我们对其分离菌株进行了一些相关的实验研究,现报道如下. 相似文献
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报道1例由球形孢子丝菌所致的婴儿固定型孢子丝菌病。患儿女,3个月,因左眼下内侧皮损2个月就诊,皮损脓液标本进行真菌培养,对培养获得菌株进行形态学、生理学和分子生物学鉴定,并进行药物敏感性检测。真菌培养阳性,镜下可见典型的套袖样菌丝。钙调蛋白基因序列分析鉴定为球形孢子丝菌。药敏试验显示特比萘芬和伊曲康唑对该菌株的菌丝相最低抑菌浓度(minimal inhibitorycon centration,MIC)分别为0.5μg/mL和0.5μg/mL;对该菌株的酵母相的MIC值分别为0.25μg/mL和0.5μg/mL。给予患者口服特比萘芬32.5mg/d治疗10周后皮损消退呈瘢痕化修复。依据临床及实验室检查确诊该病例为球形孢子丝菌所致固定型孢子丝菌病,特比萘芬治疗本病例显示较好疗效。 相似文献
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1资料与方法
1.1临床资料
患者男.56岁,因右侧腰、腹部,右上肢,右背部红斑、鳞屑、瘙痒3个月余,于2007年5月来我院就诊。患者于就诊4个月前右侧腰部开始出现红斑,渐向周围扩大,并出现鳞屑,瘙痒明显:自认为患“湿疹”,外用“皮炎平,艾洛松、尤卓尔”等药物治疗每次使用上述药物后红斑消退,停药后皮损再次出现,并向周围扩展。2个月前于右上肢出现红斑、鳞屑、瘙痒,并且扩大,20余d前又于背部出现类似皮损。 相似文献
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Summary After making some considerations concerning the therapeutic methods used in the treatment of sporotrichosis, the case of a 45 years old woman with numerous tumor-like dermoepidermic lesions with lymphangitic dissemination of sporotrichosis of the left leg is presented. Treatment by immersing the affected limb in a waterbath at 45° C for 30 minutes 4 times daily was performed. After the third day of treatment the lesions began to improve, and the number of colonies in the cultures decreased. After the 21th day of treatment cultures from the lesions were consistently negative. After 8 weeks of treatment the patient was discharged and a year later there have been no recurrences. The effect of temperature on this organism and the distribution of lesions in patients in the tropics are discussed.
Resumen Después de hacer algunas consideraciones sobre los procedimientos terapéuticos utilizados en la esporotricosis, se presenta un caso de esporotricosis, con gran número de lesiones tumorales dermoepidérmicas y diseminación linfática, localizada en la pierna izquierda de una mujer de 45 años de edad.El tratamiento de esta paciente por medio de inmersión del miembro afectado en un baño de agua a 45° C durante 30 minutos 4 veces al día, determinó que desde el tercer día comenzaron a mejorar las lesiones y a disminuir el número de colonias en los cultivos tomados de las mismas. A partir del 21° día de tratamiento los cultivos sembrados con material de las lesiones fueron siempre negativos. Se consideró terminado el tratamiento al cabo de 8 semanas. Un año más tarde no se había presentado recidiva.Se hacen algunas consideraciones sobre los mecanismos de acción de los yoduros y el calor en la esporotricosis y del calor en otras enfermedades cutáneas producidas por protozoarios o por virus. Se señala el hecho de que en zonas tropicales como Centro América no se conocen casos de esporotricosis visceral u ósea.相似文献
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OBJECTIVE--To evaluate the effect of short term treatment with terbinafine on dermatophytosis. DESIGN--Multicentre, randomised, double blind placebo controlled trial of 250 mg/day terbinafine for 12 weeks in dermatophyte onychomycosis. SETTING--Eight dermatology centres in the United Kingdom. PATIENTS--112 patients (mean age 44, range 19-78), 99 with mycologically proved toenail infections and 13 with fingernail infections, of whom eight were subsequently excluded and 19 failed to complete the study. INTERVENTION--Terbinafine 250 mg daily or placebo for 12 weeks. Follow up for 36 weeks after stopping treatment. MAIN OUTCOME MEASURES--Mycological cure (negative results on microscopy and culture) and clinical cure at the end of follow up, adverse events, and biochemical and haematological variables at monthly intervals during treatment. RESULTS--After follow up 82% (37/45) (95% confidence interval 68% to 92%) mycological cure and 69% clinical cure were recorded for evaluable patients treated with terbinafine for toenail infection and 71% (5/7) (30% to 96%) mycological cure and clinical cure for those treated for fingernail infection. The corresponding values for those treated with placebo were 12% (3% to 31%) mycological cure and no clinical cure for toenail infections and 33% (1% to 91%) mycological cure and no clinical cure for fingernail infections. On an intention to treat basis for toenail infections the figures were 73% (38/52) (58% to 85%) mycological cure for terbinafine compared with 6% (0% to 30%) for placebo (p less than 0.007). Two withdrawals were related to adverse events with terbinafine, and there were no significant abnormal laboratory test results. CONCLUSION--12 weeks'' terbinafine is effective and safe treatment for nail dermatophytosis. 相似文献
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Fonseca-Reyes S López Maldonado FJ Miranda-Ackerman RC Vélez-Gómez E Alvarez-Iñiguez P Velarde-Rivera FA Ascensio-Esparza EP 《Revista iberoamericana de micología》2007,24(1):41-43
We report an unusual case of disseminated cutaneous sporotrichosis with oral mucous and tracheal involvement in a forty-year-old male with a history of heavy drinking and liver cirrhosis. We also review the literature and other similar published cases. 相似文献
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Potassium Iodide is the antimycotic of choice for the treatment of cutaneous sporotrichosis, because of its efficacy, safety
and low cost. We carried out a review of published studies on the benefits and adverse reactions of using SSKI (Saturated
Solution Potassium Iodide) as treatment for sporotrichosis, but could not identify any well-designed clinical trails. There
is an urgent need to conduct randomized double-blind placebo-controlled trials and critically assess usefulness of SSKI by
using a standardize monitoring or an effective self-report system. 相似文献
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A technique to restore the skeletal support of the postreconstruction collapsed ala is proposed. This makes use of the elastic characteristic of costal cartilage to provide a natural spring to elevate the ala and thereby enlarge the nostril. Three illustrative cases are described. 相似文献
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de-Oliveira-Nobre M Pötter-de-Castro A Caetano D Leonardo-de-Souza L Araujo-Meireles MC Ferreiro L 《Revista iberoamericana de micología》2001,18(3):137-140
The aim of this work is to describe the prevalence of the disease in the same cattery after three years, and to report a case of human sporotrichosis following a cat scratch. In May 1997, four felines presenting a cachexy state and ulcerous lesions on the head, nose and limbs were examined in a veterinary clinic in the town of Rio Grande (RS-Brazil). Exudate and crusts were collected for microbiological diagnosis. The cat's owner returned to the clinic reporting that another eleven felines presented similar lesions. She had ulcerous lesions on her hand and ascending lymphangitis. She was conducted to medical examination where exudate and crusts from the lesions were collected and after the culture Sporothrix schenckii was isolated. After three years the same person sought veterinary assistance for seven more cats with similar lesions to the five previously described. Microbiological tests resulted again in isolation of S. schenckii. Treatment with potassium iodine was effective for the cure of human sporotrichosis, whereas for the felines it showed toxic effect. Only one showed regression of the disease while all the others presented progression of the lesions or even death. The authors call attention to the possible persistence of S. schenckii in cat populations. 相似文献
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The case of a 7-year-old boy born with exstrophy of the bladder is presented. Biofeedback and behavioral therapy were employed in the treatment of anal incontinence, which occurred following ureterosigmoidostomy diversion. After 19 treatment and follow-up sessions over a period of 12 months, there was significant decrease in fecal/urinary incontinence. The patient was soiled 29% of waking hours over the first 4 weeks of treatment. This figure dropped to 9.7% over the last three sessions. Subjective satisfaction of parent, child, and teachers was high. These gains were maintained over a 12-month follow-up period. Given the design of the present study, it is not possible to determine whether the biofeedback per se had a specific treatment effect. The case demonstrates the usefulness of a broad-based behavior therapy in the management of fecal/urine soiling, which is a frequent, refractory complication of ureterosigmoidostomy. 相似文献
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Dr. Paul N. Duckro Michaela Purcell John Gregory Karl Schultz 《Applied psychophysiology and biofeedback》1985,10(4):325-333
The case of a 7-year-old boy born with exstrophy of the bladder is presented. Biofeedback and behavioral therapy were employed in the treatment of anal incontinence, which occurred following ureterosigmoidostomy diversion. After 19 treatment and follow-up sessions over a period of 12 months, there was significant decrease in fecal/urinary incontinence. The patient was soiled 29% of waking hours over the first 4 weeks of treatment. This figure dropped to 9.7% over the last three sessions. Subjective satisfaction of parent, child, and teachers was high. These gains were maintained over a 12-month follow-up period. Given the design of the present study, it is not possible to determine whether the biofeedback per se had a specific treatment effect. The case demonstrates the usefulness of a broad-based behavior therapy in the management of fecal/urine soiling, which is a frequent, refractory complication of ureterosigmoidostomy. 相似文献