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Isolation and expression of a human ornithine decarboxylase gene 总被引:8,自引:0,他引:8
J A Moshier J D Gilbert M Skunca J Dosescu K M Almodovar G D Luk 《The Journal of biological chemistry》1990,265(9):4884-4892
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Ornithine decarboxylase (ODC) is the first enzyme in polyamine biosynthesis in numerous living organisms, from bacteria to mammalian cells. Its control is under negative feedback regulation by the end products of the pathway. In dimorphic fungi, ODC activity and therefore polyamine concentrations are related to the morphogenetic process. From the fission yeast Schizosaccharomyces pombe to human, polyamines induce antizyme synthesis which in turn inactivates ODC. This is hydrolyzed by the 26S proteasome without ubiquitination. The regulatory mechanism of antizyme on polyamines is conserved, although to date no antizyme homology has been identified in some fungal species. The components that are responsible for regulating polyamine levels in cells and the current knowledge of ODC regulation in dimorphic fungi are presented in this review. ODC degradation is of particular interest because inhibitors of this pathway may lead to the discovery of novel antifungal drugs. 相似文献
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Isolation and characterization of the mouse ornithine decarboxylase gene 总被引:15,自引:0,他引:15
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Regulation of Saccharomyces cerevisiae ornithine decarboxylase expression in response to polyamine 总被引:4,自引:0,他引:4
W A Fonzi 《The Journal of biological chemistry》1989,264(30):18110-18118
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Transcriptional analysis of the mouse beta-casein gene 总被引:1,自引:0,他引:1