共查询到20条相似文献,搜索用时 15 毫秒
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Liberek B Melcer A Osuch A Wakieć R Milewski S Wiśniewski A 《Carbohydrate research》2005,340(11):1876-1884
Mono- and di-N-alkylated derivatives of 1,3,4,6-tetra-O-acetyl-2-amino-2-deoxy-beta-D-glucose (alkyl=methyl, ethyl, propyl, butyl, pentyl, hexyl, benzyl) were synthesised by the reductive alkylation of per-O-acetyl-d-glucosamine. (N-ethyl, N-propyl, N-butyl, N-pentyl and N-hexyl)-1,3,4,6-tetra-O-acetyl-2-amino-2-deoxy-beta-D-glucoses were deacetylated in order to attempt an enzymatic phosphorylation. All products were characterised by means of IR, NMR and MS spectra. N-Ethyl- and N-pentyl-d-glucosamines were found to exhibit weak antifungal activity. 相似文献
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Ion exchange chromatography of 2-amino-2-deoxy-D-hexoses 总被引:3,自引:0,他引:3
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2-Amino-2-deoxy-D-erythrose was isolated from the cell wall of the fruit body of Agaricus bisporus. The structure of the amino sugar was determined by mass spectrography and 1H-NMR spectrography of its acetylated derivative and by paper chromatographic comparisons with authentic 2-amino-2-deoxy-D-erythrose. This amino sugar is a component of the glycoprotein fraction from the cell wall. Its content in the glycoprotein increased markedly, especially during the ripening stage of the fruit body. 相似文献
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Bednarczyk D Kaca W Myszka H Serwecińska L Smiatacz Z Zaborowski A 《Carbohydrate research》2000,328(3):249-252
The N-trifluoroacetyl- and N-tetrachlorophthaloyl-protected bromide of D-glucosamine has been used for the first time as a glycosyl donor for the glycosylation of diosgenin [(25R)-spirost-5-en-3beta-ol]. Both 1,3,4,6-tetra-O-acetyl-2-deoxy-2-trifluoroacetamido-beta-D-glucopy ranoside and 1,3,4,6-tetra-O-acetyl-2-deoxy-2-tetrachlorophthalimido-alpha,beta -D-glucopyranoside were transformed into the appropriate glycosyl bromides. These reacted with diosgenin under mild conditions, using silver triflate as a promoter, and gave the corresponding protected diosgenyl glycosides. Each was deprotected to give diosgenyl 2-amino-2-deoxy-beta-D-glucopyranoside hydrochloride. The structures of the new glycosides were established by 1H NMR spectroscopy. 相似文献
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We studied the behaviour of 8-azido-2'-deoxyadenosine and 8-bromo-2'-deoxyadenosine in aqueous solutions of ammonia and primary and secondary amines. Unexpectedly, 8-Azido-2'-deoxyadenosine is converted to 8-amino-2'-deoxyadenosine in excellent yields. The use of this reaction for the preparation of 8-aminoadenine derivatives needed for the preparation of oligonucleotides carrying 8-aminoadenine is discussed. 相似文献
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2-Amino-2-deoxy-d-glucose (10mM) as the free base (pH 8.5) and the hydrochloride (pH 5) were γ-irradiated in aqueous solution under deoxygenated (N2O-saturated) and oxygenated [N2O/O2(4:1)-saturated] conditions. Ammonia and 18 nitrogen-free products were identified and their G-values determined. Mechanisms for the radical-induced deamination are proposed. The radicals centered at C-1, C-2, C-3, and the nitrogen are suggested as initiators in the deamination processes. 相似文献
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