Health Risks of Metals in Soil,Water, and Major Food Crops in Hamedan Province,Iran

Food, drinking water, soil, and air are the main routes of exposure to trace metals, thus the assessment of the risks posed to humans by these elements is important. Wheat, potatoes, and maize are very important parts of the Iranian diet. The objectives of this study were to estimate the non-carcinogenic and carcinogenic health risks of Hg, Pb, Cd, Cr, Se, As, and Ni to adults and children via soil, water, and major food crops consumed in Hamedan Province, northwest Iran, using the total non-cancer hazard quotient (THQ) and cancer risk assessment estimates. Total non-cancer hazard of Ni and Hg, were greater than 1, and total cancer risk of As and Pb was greater than 1 × 10^?6. Food consumption was identified as the major route of human exposure to metals, and consuming foodstuff threatens the health of the studied population. In Hamedan Province, consumption of wheat is the main source of intake of metals from foodstuff for adults, and in children, the soil ingestion route is also important.     

Evaluation of farmers' attitude and perception toward production risk: Lessons from Khyber Pakhtunkhwa Province,Pakistan

The variations in farming risk are classified into three key categories: market liberalization, natural disasters such as floods or drought, and climate change. This study aims at filling the existing research gap by the assessment of risk attitude and risk perceptions toward various types of risks. Primary data of 600 respondents were collected through a structured questionnaire in four flood-prone districts namely Peshawar, Mardan, Charsadda, and Nowshera of Khyber Pakhtunkhwa (KP) province of Pakistan. Equally Likely Certainty Equivalent and risk matrix techniques were utilized in determining the risk attitude and risk perceptions among the farmers. A probit regression model was used to analyze the relationships among dependent and independent variables. Findings of the study show that majority of the farmers were risk-averse, and floods, high input prices, crop diseases, and excessive precipitation were the main risks perceived by the farmers. Results of the probit regression model indicated that age, education level, farm location, off-farm income, and access to market information were the main factors that affect the farmers' risk attitude and perceptions. The research offers essential findings that can be used by policy-makers in the farming sector and researchers to understand risk attitude and perceptions of farmers empirically.     

A Fuzzy Logic Approach to Assess,Manage, and Communicate Carcinogenic Risk

A prospective approach to addressing carcinogen risk assessment is presented. Fuzzy reasoning is used to assess carcinogenic risk, characterize it, and control it. The approach is inspired by fuzzy control inference that deploys linguistic intelligence as input to a system described numerically through membership functions. Fuzzy-based reasoning to estimate carcinogenic risk provides several advantages as discussed here. The fuzzy reasoning approach has more capabilities than traditional models in dealing with risk agents that are probably carcinogens, possibly carcinogens, not classifiable as carcinogens, and probably not carcinogens. Input–output surfaces are presented for each hazard group to enable fast inferencing. Then, a hypothetical example is given to compare the results of traditional methods and the fuzzy-based approach to estimating the risk of a carcinogen to a human population. Results show similarity in risk characterization with less input information to the fuzzy-based approach. Fuzzy reasoning characterizes risk in more explicit and easy to grasp terms. Two outputs of the inferencing system are risk characterization and risk control or remediation.     

Assessing the Human,Social, and Environmental Risks of Pervasive Computing

The vision of Pervasive Computing is built on the assumption that computers will become part of everyday objects, augmenting them with information services and enhanced functionality. This article reports on the approach we have used to assess potential side effects of this development on human health and the environment, and the major risks we identified. Social risks such as the risk of conflicts between users and non-users of the technology were also included because of their potential indirect adverse health effects. Assessing a technological vision before it has materialized makes it necessary to deal with two types of uncertainty: first, the uncertainty of how fast and to what extent the technology will be taken up and how it will be used; second, the uncertainty of causal models connecting technology-related causes with potential health or environmental effects. Due to these uncertainties, quantitative methods to evaluate expected risks are inadequate. Instead, we developed a “risk filter” that makes it possible to rank risks according to a set of qualitative criteria based on the Precautionary Principle. As the overall result, it turned out that Pervasive Computing bears potential risks to health, society, and/or the environment in the following fields: Non-ionizing radiation, stress imposed on the user, restriction of consumers' and patients' freedom of choice, threats to ecological sustainability, and dissipation of responsibility in computer-controlled environments.     

Arsenic in groundwater and its health risk assessment in drinking water of Mailsi,Punjab, Pakistan

The present study was aimed at assessing drinking water quality regarding arsenic (As) and its impact on health from Mailsi (Punjab), Pakistan. Forty-four groundwater samples were collected from two sites, Sargana and Mailsi. Arsenic and other cations were determined by atomic absorption spectrophotometer, whereas the anions were determined either through titration or spectrophotometer. The results revealed that dominant anions were HCO₃^? and Cl^?, Ca⁺² was the dominant cation, and overall water chemistry of the area was CaMgHCO₃^? type. Arsenic concentrations were high, ranging from 11 to 828 µg/L that crossed the World Health Organization permissible limits. Likewise, higher SO₄^?2 concentrations ranging from 247 to 1053 mg/L were observed. The health risk index was higher in the Sargana site, which employed the differences in terms of higher Average Daily Dose, Hazard Quotient, and Carcinogenic Risk of arsenic, which is unsuitable for drinking purposes. The area seems to be at high risk due to arsenic pollution and wells have never been tested for arsenic concentrations earlier; therefore, necessary measures should be taken to test the wells with respect to arsenic.     

Lipoprotein-associated phospholipase A2, and subsequent cardiovascular events and mortality among patients with coronary heart disease

Objective: The objective of this study is to evaluate the relevance of Lp-PLA₂ to risk prediction among coronary heart disease (CHD) patients.

Methods: Lp-PLA₂ activity was measured in 2538 CHD patients included in the Bezafibrate Infarction Prevention (BIP) study.

Results: Adjusting for patient characteristics and traditional risk factors, 1 standard deviation of Lp-PLA₂ was associated with a hazard ratio (HR) of 1.12 (95% confidence interval (CI): 1.00–1.25) for mortality and 1.03 (0.93–1.14) for cardiovascular events. Lp-PLA₂ did not significantly improve model discrimination, or calibration nor result in noteworthy reclassification.

Conclusions: Our results do not support added value of Lp-PLA₂ for predicting cardiovascular events or mortality among CHD patients beyond traditional risk factor.     

Comparison of demography, diet, lifestyle, and serum lipid levels between the Guangxi Bai Ku Yao and Han populations

Bai Ku Yao is an isolated subgroup of the Yao minority in China. Little is known about dyslipidemia in this population. The aim of this study was to compare the effects of demography, diet, and lifestyle on serum lipid levels between the Bai Ku Yao and Han populations. A total of 1,170 subjects of Bai Ku Yao and 1,173 subjects of Han Chinese aged 15-89 years were surveyed by a stratified randomized cluster sampling. The levels of total cholesterol, high density lipoprotein cholesterol, low density lipoprotein cholesterol, apolipoprotein A-I (apoA-I), and apoB were significantly lower in Bai Ku Yao than in Han. Physical activity level and total dietary fiber intake were higher, whereas body mass index (BMI), waist circumference, total energy intake, and total fat intake were lower in Bai Ku Yao than in Han. Hyperlipidemia was positively correlated with BMI, waist circumference, and total energy and total fat intakes and negatively associated with physical activity level and total dietary fiber intake in both populations, but it was positively associated with age and alcohol consumption only in Han. The differences in the lipid profiles between the two ethnic groups were associated with different dietary habits, lifestyle choices, and levels of physical activities.     

Safety risk management for low molecular weight process-related impurities in monoclonal antibody therapeutics: Categorization,risk assessment,testing strategy,and process development with leveraging clearance potential

Process-related impurities (PRIs) derived from manufacturing process should be minimized in final drug product. ICH Q3A provides a regulatory road map for PRIs but excludes biologic drugs like monoclonal antibodies (mAbs) that contain biological PRIs (e.g. host cell proteins and DNA) and low molecular weight (LMW) PRIs (e.g., fermentation media components and downstream chemical reagents). Risks from the former PRIs are typically addressed by routine tests to meet regulatory expectations, while a similar routine-testing strategy is unrealistic and unnecessary for LMW PRIs, and thus a risk-assessment-guided testing strategy is often utilized. In this report, we discuss a safety risk management strategy including categorization, risk assessment, testing strategy, and its integrations with other CMC development activities, as well as downstream clearance potentials. The clearance data from 28 mAbs successfully addressed safety concerns but did not fully reveal the process clearance potentials. Therefore, we carried out studies with 13 commonly seen LMW PRIs in a typical downstream process for mAbs. Generally, Protein A chromatography and cation exchange chromatography operating in bind-and-elute mode showed excellent clearances with greater than 1,000- and 100-fold clearance, respectively. The diafiltration step had better clearance (greater than 100-fold) for the positively and neutrally charged LMW PRIs than for the negatively charged or hydrophobic PRIs. We propose that a typical mAb downstream process provides an overall clearance of 5,000-fold. Additionally, the determined sieving coefficients will facilitate diafiltration process development. This report helps establish effective safety risk management and downstream process design with robust clearance for LMW PRIs.     

Human risk associated with the ingestion of artichokes grown in soils irrigated with water contaminated by potentially toxic elements,Junin, Peru

The contamination of water, air and soil with potentially toxic elements (PTE) compromises the supply of contaminant free food. Vegetables grown in contaminated soils can absorb and accumulate PTE at concentrations that are toxic to human health. In this context, the human risk associated with the intake of artichokes grown in soils irrigated with PTE contaminated water was assessed. 120 samples of surface soil and artichoke heads were collected and the concentrations of Cu, Fe, Pb, Zn and As were determined. The results showed that the concentrations of Cu, Fe and Zn in soil did not exceed the standards of the Ministry of Environment of Peru, but they did exceed those of Pb (125.45 mg kg⁻¹) and As (28.70 mg kg⁻¹). The decreasing order of mean PTE concentration in artichoke heads was Fe > Zn > Cu > Pb > As, exceeding the permissible levels of FAO/WHO CODEX Alimentarius. However, the concentrations of As comply with the maximum limits of inorganic contaminants in vegetables (0.3 mg kg⁻¹) established in the MERCOSUR regulations. The non-carcinogenic and carcinogenic risk of Pb and As indicated that the ingestion of artichoke heads does not represent a health risk.     

Association of CELSR2, APOB100, ABCG5/8, LDLR,and APOE polymorphisms and their genetic risks with lipids among the Thai subjects

BackgroundHypercholesterolemia is a common cardiovascular risk factor. The aim of this study was to investigate the association of CELSR2 (rs629301), APOB100 (rs1367117), ABCG5/8 (rs6544713), LDLR (rs6511720), and APOE (rs429358, rs7412) polymorphisms, and their genetic risk scores with lipids among Thai subjects.MethodsA total of 459 study subjects (184 males, and 275 females) were enrolled. Blood pressure, serum lipids, and fasting blood sugar were measured. CELSR2 (rs629301), APOB100 (rs1367117), ABCG5/8 (rs6544713), and LDLR (rs6511720) polymorphisms were analyzed using PCR-HRM. APOE (rs429358, rs7412) polymorphism was analyzed using PCR-RFLP.ResultsTotal cholesterol (TC) levels were significantly higher in APOB100 AA genotype compared with GG, or AA + AG genotypes in total subjects. In addition, significantly higher concentrations of TC and low density lipoprotein cholesterol (LDL-C) were observed in APOE4 carriers compared to APOE2 carriers in total subjects, males, and females. The significantly higher concentrations of TC were observed in APOE4 carriers compared to APOE3 carriers in females. Moreover, the concentrations of TC, and LDL-C were significantly increased with genetic risk scores of APOB100, and APOE polymorphisms in total subjects, and females. There was no association between CELSR2 (rs629301), ABCG5/8 (rs6544713), and LDLR (rs6511720) polymorphisms and serum lipids.ConclusionAPOB100 (rs1367117), and APOE (rs429358, rs7412) but not CELSR2 (rs629301), ABCG5/8 (rs6544713), and LDLR (rs6511720) polymorphisms were associated with serum lipids. The cumulative risk alleles of APOB100 (rs1367117), and APOE (rs429358, rs7412) polymorphisms could enhance the elevated concentrations of TC, and LDL-C, and they may be used to predict severity of hypercholesterolemia among Thai subjects.     

广东省川山群岛开发利用生态风险评价

随着海洋经济的迅猛发展,海岛的开发利用程度不断加大,海岛生态环境遭到极大地冲击和破坏,导致海岛生态系统出现环境恶化、灾害加剧的趋势。广东省川山群岛,主岛为上川岛和下川岛,因岛上旅游娱乐和养殖用海等开发利用活动频繁,使其生态系统面临严峻的挑战。根据EPA提出的生态风险评价框架,分析了川山群岛的生态终点、生境类型和压力源状况,构建了一个用以描述川山群岛压力源、生境和评估终点间相互关系的概念模型,采用RRM模型思想进行了川山群岛开发利用风险评价。结果表明:上川岛属于开发利用的高风险区,主要风险区域是潮间带和近海两个生态子系统,其中以岩滩的开发利用压力最大,旅游娱乐和养殖用海是风险压力的主要来源,珍稀水禽是主要受威胁的物种;下川岛较上川岛的开发利用风险低,其岛陆、潮间带和近海3个生态子系统的开发利用压力都不大,养殖用海、旅游娱乐和城镇用地是风险压力的主要来源,也是威胁珍稀水禽和猛禽的主要压力源。基于此,从旅游管理、养殖用海管理等方面给出了上川岛和下川岛的风险管理对策,以期为海岛环境保护和可持续利用提供科学依据。     

Odds and Ends: Risk,Mortality, and the Politics of Contingency

Medical anthropology's cogentrethinking of conventional biomedicalcategories has largely overlooked the coreproblems of one key concept of both biomedicaland social scientific analysis: risk. Inparticular, the use of the term in medicalanthropology (and the social sciences moregenerally) frequently rests on two assumptions:(1) that contingency necessarily constitutes athreat to individual experience or socialorder; and (2) that a risk management paradigmthat relies on a model of statisticalprobability is the ontologically preeminent wayof engaging chance. Other approaches which donot take risk as the starting point forunderstanding contingency also have problems;they too assume that contingency is necessarilycause for crisis. These problematic rootassumptions lead social analysts to miss howindividual actors and local communitiesvariously engage, rather than minimize,contingency. I suggest a new approach thatinstead aims to treat contingency asnormatively neutral and as arising in fourdomains of experience. Conventional approachesalso miss how attempts to account forunexpected events themselves involve strugglesbetween competing paradigms (or tropes) ofchance. This contest over accountability I callhere the politics of contingency, and Iseek thereby to signal the need to renovate ourlanguage of uncertainty in order to address itspolitical dimensions. I trace the literature toidentify some sources of these terminologicalproblems, and through an examination of thelife and death of a close contact in Chania,Crete, I explore his own approach to chance andthe different, competing interpretations of hisdeath. I thereby demonstrate the importance ofrevamping the conventional approach tounderstanding the contingent nature of humanlife.     

Livestock waste treatment systems for environmental quality,food safety,and sustainability

The intensification of livestock operations has benefited production efficiency but has introduced major environmental issues, becoming a concern in both developed and developing countries. The aim of this paper is primarily to address the impact of the livestock sector on environmental pollution (ammonia, greenhouse gases and pathogens), evaluate the related health risks and, subsequently, assess the potential role of waste treatment systems in attenuating these environmental and health issues. This paper is a collection of data pertaining to world trends in livestock production, since the mid 1990s and intensive livestock farming practices along with their impact on: water pollution by nitrates and through eutrophication; air pollution, particularly ammonia and greenhouse gases emissions, and soil pollution because of nutrient accumulation. Finally, this paper examines some of the benefits of treating livestock manures, issues related to the adoption of treatment systems by livestock operations and current as well as past technological developments.     

Risk knowledge,product knowledge,and brand benefits for purchase intentions: Experiences with air purifiers against city smog in China

The present study is based on the theoretical framework of protective action decision model. This study aims to explain the relationship among the risk knowledge, product knowledge, risk perception, and brand benefits and the consumers’ purchase intentions of a specific air purifier compared with alternative brands. The research context is city smog. Results show that consumers’ risk knowledge and product knowledge significantly affect their purchase of an air purifier brand as well as play a considerable role in predicting their risk perception and in foreseeing their purchase intentions under the influence of the manufacturer's advertising strategies. Furthermore, consumers’ risk perception is a critical psychological factor that has a significantly positive influence on brand's experiential benefits, instead of functional and symbolic benefits. In particular, when comparing with brand's functional and symbolic benefits, the brand's experiential benefits is more attractive to consumers and has a stronger effect on consumers’ air purifier purchase intentions in the context of city smog.     

Climatic,ecological, and socioeconomic factors associated with West Nile virus incidence in Atlanta,Georgia, U.S.A.

The integrated effects of the many risk factors associated with West Nile virus (WNV) incidence are complex and not well understood. We studied an array of risk factors in and around Atlanta, GA, that have been shown to be linked with WNV in other locations. This array was comprehensive and included climate and meteorological metrics, vegetation characteristics, land use / land cover analyses, and socioeconomic factors. Data on mosquito abundance and WNV mosquito infection rates were obtained for 58 sites and covered 2009–2011, a period following the combined storm water – sewer overflow remediation in that city. Risk factors were compared to mosquito abundance and the WNV vector index (VI) using regression analyses individually and in combination. Lagged climate variables, including soil moisture and temperature, were significantly correlated (positively) with vector index as were forest patch size and percent pine composition of patches (both negatively). Socioeconomic factors that were most highly correlated (positively) with the VI included the proportion of low income households and homes built before 1960 and housing density. The model selected through stepwise regression that related risk factors to the VI included (in the order of decreasing influence) proportion of houses built before 1960, percent of pine in patches, and proportion of low income households.     

Regional ecological risk assessment using a relative risk model: A case study of the Darwin Harbour,Darwin, Australia

There are many proposed and ongoing commercial, industrial, and residential developments within the Darwin Harbour catchment in Northern Australia, to accommodate the projected population growth over the next 20 years. Hence, it is necessary to ensure the balance between these developments and ecosystem conservation. We evaluated ecological risk for the Darwin Harbour using a relative risk model (RRM). The catchment was divided into 22 risk regions based on small catchment boundaries and their homogeneity. Through the RRM, we ranked and summed the stressors and habitats within regions. The interaction between stressors and habitats were modeled through exposure and effect filters. The ecological assessment endpoints were maintenance of the mangrove health and the maintenance of water quality. The risk regions—Myrmidon Creek, Blackmore River, Bleesers Creek, and Elizabeth River—showed the highest total relative risk for ecological assets. These risk regions had a high percentage cover of industrial, commercial, and residential areas; diffuse entry points; and climate change effects. Creek A, Sandy Creek, West Arm, and Pioneer Creek were the risk regions with lowest total relative risk scores. The RRM is a robust application that is suitable for a large geographic area where multiple stressors are of concern.     

Risk Assessment for Natural Uranium in Subsurface Water of Punjab State,India

Traces of uranium were measured by laser fluorimeter in 235 subsurface water samples collected from four districts of Punjab state in India. The concentration of U in water samples ranged between <2–644 μg/L with a mean value of 73.1 μg/L. The radiological risk was observed to be in the range of 5.55 × 10^?6–1.78 × 10^?3 with a mean value of 2.03 × 10^?4, which is around 22% more than the maximum acceptable level (l.67 × 10^?4) as per guidelines of India's Atomic Energy Regulatory Board. The mean of chemical toxicity risk, expressed as life time average daily dose (LADD) was worked out to be 5.56 μg/kg/day with a range of 0.15–48 μg/kg/day by considering a bodyweight of 51.5 ± 8.5 kg, water ingestion rate of 4.05 L/d, and life expectancy of 63.7 yrs for an adult Indian reference man and compared with the reference dose (4.53 μg/kg/day). The average exposure level of U was comparatively high and the chemical toxicity was expected to be more. The mean of hazard quotient (LADD/ RfD) for all four districts was found to be greater than 1, indicating that groundwater may not be suitable for consumption from a chemical toxicity point of view.