共查询到20条相似文献,搜索用时 62 毫秒
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CSL: a notch above the rest 总被引:1,自引:0,他引:1
Pursglove SE Mackay JP 《The international journal of biochemistry & cell biology》2005,37(12):2472-2477
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The Notch pathway regulates the differentiation of many cell types throughout development of higher metazoa. Different cellular responses are elicited through specific activation of distinct Notch target genes. In the Drosophila wing, for example, the cut gene is activated by Notch signaling along the dorso-ventral boundary but, as we show here, not in other cell types. We identify additional regulatory components, scalloped and strawberry notch, that are targets of the Notch pathway specifically within the wing anlagen. As suggested by physical interactions, these proteins could be co-factors of the cut trans-regulator Vestigial. Additional regulatory input comes from the Wingless pathway. Our data support a model, whereby context specific involvement of distinct co-regulators modulates Notch target gene activation. 相似文献
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Keeping a good pathway down: transcriptional repression of Notch pathway target genes by CSL proteins 总被引:1,自引:0,他引:1
Lai EC 《EMBO reports》2002,3(9):840-845
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T. L. Sladek 《Cell proliferation》1997,30(3):97-105
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Modulation of vascular gene expression by hypoxia 总被引:1,自引:0,他引:1