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GATA-dependent recruitment of MEF2 proteins to target promoters   总被引:38,自引:0,他引:38  
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Myocyte enhancer factor 2 (MEF2)   总被引:2,自引:0,他引:2  
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Vertebrate paralogous MEF2 genes: origin, conservation, and evolution   总被引:1,自引:0,他引:1  
Wu W  de Folter S  Shen X  Zhang W  Tao S 《PloS one》2011,6(3):e17334
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《Autophagy》2013,9(7):1073-1074
Chaperone mediated autophagy (CMA) targets specific cytoplasmic proteins for degradation by lysosomes and has been implicated to play a role in neurodegeneration. Our recent studies identify neuronal survival factor MEF2D as a direct substrate of CMA and show that dysregulation of this process may contribute to the pathogenesis of Parkinson disease. One interesting finding presented in our study is the apparent loss of DNA binding capacity by the accumulated MEF2D following inhibition of CMA. The possibilities and implication of this finding are discussed.  相似文献   

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