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Thyroid nuclear factor 1 (TTF-1) contains a homeodomain and displays a novel DNA binding specificity. 总被引:32,自引:3,他引:29
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The cDNA for TTF-1, a thyroid nuclear factor that binds to the promoter of thyroid specific genes, has been cloned. The protein encoded by the cDNA shows binding properties indistinguishable from those of TTF-1 present in nuclear extracts of differentiated rat thyroid cells. The DNA binding domain of TTF-1 is a novel mammalian homeodomain that shows considerable sequence homology to the Drosophila NK-2 homeodomain. TTF-1 mRNA and corresponding binding activity are detected in thyroid and lung. The chromosomal localization of the TTF-1 gene has been determined in humans and mice and corresponds to chromosomes 14 and 12, respectively, demonstrating that the TTF-1 gene is not located within previously described clusters of homeobox-containing genes. 相似文献
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Thyroid transcription factor-1 总被引:2,自引:0,他引:2
Colin D. Bingle 《The international journal of biochemistry & cell biology》1997,29(12):1471-1473
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Kim JG Nam-Goong IS Yun CH Jeong JK Kim ES Park JJ Lee YC Kim YI Lee BJ 《Biochemical and biophysical research communications》2006,349(3):969-975
TTF-1 is a member of the NKx family of homeodomain genes, and is required for morphogenesis and fetal diencephalon development. Our previous studies have shown that TTF-1 expression is maintained in some regions of the postnatal rat brain and transactivates the gene expression of several neuropeptides. In this study, a potential role for TTF-1 in the regulation of feeding behavior was identified. Immunohistochemical analysis showed that TTF-1 is present in several hypothalamic nuclei of the adult rat brain involved in the control of feeding behavior. Food deprivation for two days markedly increased the hypothalamic levels of TTF-1 mRNA and protein. Intracerebroventricular administration of an antisense TTF-1 oligodeoxynucleotide significantly decreased TTF-1 protein abundance in the hypothalamus. This TTF-1 decrease was followed by a significant decrease in neuropeptide Y mRNA content and an increase in proopiomelanocortin mRNA content, and in turn resulted in a decrease of the animal's food intake and body weight. These results suggest a novel role for TTF-1 in the regulation of feeding behavior in the rat hypothalamus. 相似文献
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Pendrin is a novel in vivo downstream target gene of the TTF-1/Nkx-2.1 homeodomain transcription factor in differentiated thyroid cells
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Dentice M Luongo C Elefante A Ambrosio R Salzano S Zannini M Nitsch R Di Lauro R Rossi G Fenzi G Salvatore D 《Molecular and cellular biology》2005,25(22):10171-10182
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