成人原发肾病综合征患者血尿酸与血脂代谢的关系

目的:研究成人原发肾病综合征(PNS)患者高尿酸血症的患病率及其与血脂代谢的关系。方法:将109例成人PNS患者根据其尿酸水平分为高尿酸血症组与血尿酸正常组,检测患者的血脂、血清脂蛋白、ALB及24小时尿蛋白定量,分析成人PNS患者高尿酸血症的患病率,比较高尿酸血症组与血尿酸正常组PNS患者的一般情况及血脂水平,并分析PNS患者血尿酸水平的相关因素。结果:成人PNS患者高尿酸血症的发病率为24.77%;高尿酸血症组患者TG及24小时尿蛋白定量水平明显高于血尿酸正常组(P0.01),两组患者TC、LDL-C、HDL-C、Apo AI及Apo B比较差异无统计学意义(P0.05);成人PNS患者血尿酸水平与TG及24小时尿蛋白定量水平呈正相关(r=0.350,P=0.001;r=0.533,P=0.014),与TC、LDL-C、HDL-C及ALB无明显相关性(P0.05)。结论:成人PNS患者高尿酸血症的发生率较高,高尿酸血症患者具有更高的TG及尿蛋白水平,且成人PNS患者血尿酸水平与TG及24小时尿蛋白定量具有相关性,应高度重视成人PNS患者的血尿酸水平。     

代谢性综合征干预研究获新进展

代谢综合征是2型糖尿病和心血管疾病等慢性代谢性疾病的重要风险因素。近20年来,随着我国居民的膳食结构和生活方式的日渐西化,慢性代谢性疾病的患病率迅速上升。我国目前有超过有15.1%（约7.1亿）成年人患有代谢综合征。因此,发现和建立经济有效的控制代谢综合征的方法是控制这类疾病的关键环节。     

血尿酸水平与急性脑梗死相关性分析

目的探讨血尿酸水平与急性脑梗死发病及预后的关系。方法检测129例急性脑梗死患者与120例健康组的血尿酸水平及相关指标进行比较,分析其相关性。结果急性脑梗死患者血尿酸水平及异常率明显增高,与对照组之间差异存在非常显著性(P0.01),在急性脑梗死患者中,血尿酸异常组高血压、高血糖、高血脂及高纤维蛋白原血症的发生率比正常组明显增高,血尿酸异常组较正常组入院第21天神经功能缺损的程度差异存在非常显著性(P0.01)。结论血尿酸水平与急性脑梗死的发病密切相关,是预后不良的预测因素。     

代谢性炎症在代谢综合征中的作用

代谢综合征(metabolic syndrome,MS)是由代谢紊乱引发的一系列病理状况,如肥胖、2型糖尿病、动脉粥样硬化和非酒精性脂肪性肝病等.研究表明,代谢性炎症与胰岛素抵抗有着密切而复杂的联系,在MS的发生与发展中起到重要的作用.针对代谢性炎症信号通路进行研究,可为代谢性疾病的防治提供新思路.该文综述了代谢性炎症...     

血尿酸水平与冠状动脉病变程度的关系探讨

目的:探讨血尿酸(SUA)水平与冠状动脉病变程度的关系。方法:将268例疑似冠心病(CHD)患者,经冠状动脉造影分为冠心病组198例和非冠心病组70例;冠心病组又分为单支病变组80例,双支病变组56例,三支病变组62例。分别检测各组研究对象血尿酸含量,同时记录年龄、性别、吸烟、高血压、糖尿病、血尿酸及冠状动脉造影结果,分析血尿酸与已知冠心病主要危险因素、冠状动脉病变程度的相关性。结果:冠心病组血尿酸水平(395.35±84.40)μmol/L,显著高于非冠心病组(282.20±66.68)μmol/L(P<0.05)。单支病变组(338.48±77.36)μmol/L、双支病变组(399.62±84.36)μmol/L、三支病变组(445.16±92.20)μmol/L,血尿酸水平呈递增趋势,各组之间的差异有统计学意义。结论:血尿酸水平可反映冠状动脉病变严重程度。降尿酸治疗有望成为心血管疾病防治的一种新途径。     

血脂与血尿酸浓度变化在老年脂肪肝患者诊断中的价值

目的：研究血脂与血尿酸浓度变化在老年脂肪肝患者诊断中的价值。方法：选取我院三年来健康体检时确诊为脂肪肝患者 的80 例为观察组,体检结果为健康正常人的80 例为对照组。测定两组总胆固醇、甘油三酯、血尿酸、高密度脂蛋白胆固醇、低密 度脂蛋白胆固醇的值,将检测结果进行对比。结果：两组检测结果对比,观察组的总胆固醇高于对照组的(x2=11.358,P=0.015);观 察组的甘油三酯值高于对照组（x2=7.456,P=0.035）;观察组中的血尿酸,高于对照组值（x2=9.875,P=0.029）、低密度脂蛋白胆固醇 的值,高于对照组（x2=12.037,P=0.013）,高密度脂蛋白胆固醇低于对照组（x2=5.149,P=0.041）。在轻、中、重度三组脂肪肝患者中, 中度脂肪肝患者的总胆固醇、甘油三酯、血尿酸、低密度脂蛋白含量高于轻度脂肪肝患者,高密度脂蛋白含量低于轻度脂肪肝患 者,P＜0.05,差异有统计学意义;重度脂肪肝患者的总胆固醇、甘油三酯、血尿酸、低密度脂蛋白含量高于中度脂肪肝患者,高密度 脂蛋白含量低于中度脂肪肝患者,P＜0.05,差异有统计学意义。结论：脂肪肝病变程度越大,脂肪肝患者总胆固醇、甘油三酯、血尿 酸、低密度脂蛋白胆固醇的值越高,高密度脂蛋白胆固醇的值越低,血脂与血尿酸浓度变化可作为诊断脂肪肝疾病的依据,可实 现早发现、早治疗,值得应用。     

老年冠心病患者血尿酸水平与肠道菌群的关系

目的探讨老年冠心病患者血尿酸(SUA)水平与肠道菌群的关系,为该类患者的治疗提供参考。方法选择2018年5月至2019年5月我院收治的83例冠心病患者为研究组,选择同期我院83例健康体检者的作为对照组。比较两组对象SUA水平及粪便标本中肠道菌群分布情况(乳杆菌、双歧杆菌、幽门螺杆菌、大肠埃希菌、链球菌);比较不同菌群紊乱程度冠心病患者SUA水平;比较不同SUA水平冠心病患者肠道菌群分布情况。采用Pearson相关分析冠心病患者SUA水平与肠道菌群相关性。结果研究组患者肠道乳杆菌、双歧杆菌数量明显低于对照组(均P<0.05),而肠道幽门螺杆菌、大肠埃希菌、链球菌数量明显高于对照组(均P<0.05)。研究组患者SUA水平明显高于对照组(P<0.05),不同菌群紊乱程度冠心病患者SUA水平有差异有统计学意义(均P<0.05)。不同SUA水平冠心病患者肠道乳杆菌、双歧杆菌、幽门螺杆菌、大肠埃希菌、链球菌数量差异有统计学意义(均P<0.05)。冠心病患者SUA水平与肠道乳杆菌、双歧杆菌数量呈负相关(r=-0.872、-0.912,均P<0.001),与肠道幽门螺杆菌、大肠埃希菌、链球菌数量呈正相关(r=0.915、0.896、0.889,均P<0.001)。结论冠心病患者存在肠道细菌紊乱及高尿酸现象。冠心病患者SUA水平与肠道菌群显著相关,检测冠心病患者SUA水平对监测肠道菌群状态及治疗方案制定具有重要意义。     

老年人脑梗死与血脂、血糖、血尿酸关系的临床观察

人类脑血管疾病中约有 2 5 %是脑梗死 ,而脑梗死更是老年人常见病。脑血管疾病的发病率 ,老年期 ( >60岁 )是老年前期 ( 4 5～ 5 9岁 )的 3.5倍。由于脑梗死的发病会不同程度地降低老年人的生活质量 ,甚至因此而致残 ,给个人、家庭和社会都带来了极大的负担。造成老年人脑梗死的高发病率的危险因素很多 ,如高血压、糖尿病、心脏病、肥胖、血液粘度增高等。本文旨在探讨老年人群体中 ,发生脑梗死的病人与非脑梗死的病人 ,在血脂、血糖与血尿酸的生化结果上有无差异 ,及其在脑梗死发病中的意义。1　临床资料1 .1　一般资料　全部病例均为本院…     

血尿酸水平与缺血性卒中相关分析

目的:研究血尿酸水平与缺血性卒中的相关性。方法:选择缺血性卒中患者(病例组)100例和健康体检者(对照组)100例,分别测定空腹血尿酸(UA)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C),并对病例组进行颈部动脉超声检查、NIHSS评分、BI指数计算。比较两组尿酸水平及病例组不同血尿酸水平下UA、TC、TG、LDL-C、HDL-C的指标变化及NIHSS评分、BI指数、颈部血管斑块形成率的差别。结果:病例组和对照组空腹血尿酸升高的例数,分别为46例和17例,分别占46%和17%;血尿酸平均浓度分别为485.96±76.03(μmoL/L)和343.12±61.46(μmoL/L),差异有统计学意义。病例组尿酸结果明显高于对照组,两组比较有显著性差异(P<0.01);病例组UA、TC、TG、LDL-C、HDL-C水平较正常对照组差异有显著意义(P<0.05)。对病例组血尿酸水平,颈部血管超声结果、NIHSS评分、BI指数进行分析。病例组患者血尿酸水平与病情及预后有平行关系,即血尿酸水平高,颈部血管斑块形成率高,病情重,预后差。结论:高尿酸血症(HUA)是缺血性卒中重要的危险因素,是防治缺血性卒中的综合因素之一。     

脑血管疾病患者血尿酸和纤维蛋白原的测定与分析

目的:为了解脑血管疾病患者血尿酸、血浆纤维蛋白原水平及相互关系。方法:对81例脑梗死患者、77例脑出血患者和55例时照者采血测定血尿酸、血浆纤维蛋白原,并分析二者的相关性。结果:脑梗死疾病组和脑出血疾病组UA和Fib水平均高于时照组(P＜0．05);脑血管疾病组组间无差异(P□0．05);血尿酸和血浆纤维蛋白原二者间无相关性。结论:血尿酸、血浆纤维蛋白原作为脑血管疾病的危险因素可能是独立存在的。     

The role of xanthine oxidoreductase and uric acid in metabolic syndrome

Xanthine oxidoreductase (XOR) could contribute to the pathogenesis of metabolic syndrome through the oxidative stress and the inflammatory response induced by XOR-derived reactive oxygen species and uric acid. Hyperuricemia is strongly linked to hypertension, insulin resistance, obesity and hypertriglyceridemia. The serum level of XOR is correlated to triglyceride/high density lipoprotein cholesterol ratio, fasting glycemia, fasting insulinemia and insulin resistance index. Increased activity of endothelium-linked XOR may promote hypertension. In addition, XOR is implicated in pre-adipocyte differentiation and adipogenesis. XOR and uric acid play a role in cell transformation and proliferation as well as in the progression and metastatic process. Collected evidences confirm the contribution of XOR and uric acid in metabolic syndrome. However, in some circumstances XOR and uric acid may have anti-oxidant protective outcomes. The dual-face role of both XOR and uric acid explains the contradictory results obtained with XOR inhibitors and suggests caution in their therapeutic use.     

The comparison of insulin and uric acid levels in adolescents with and without metabolic syndrome

Background and Aim

The prevalence of metabolic syndrome (MS) increased in recent years in both adolescents and children groups. The aim of the study is evaluating the relationship between insulin and uric acid (UA) level in MS in adolescents

Materials and Methods

we studied 120 adolescence aged 10 to 19 in two groups: control group without metabolic syndrome and case group with metabolic syndrome. The Criteria of ATP III was considered as a diagnosis factor for metabolic syndrome.

Discussion

Various studies have been conducted in various populations to evaluate the relationship between UA level and MS in adolescents. Abdominal obesity, low HDL, hypertriglyceridemia and hypertension are associated with high UA level. In their analysis, the MS OR in UA level?4.9, 4.9-5.8 and ?5.8 mg/dl was 1, 2.53 and 9.03, respectively, which were higher than our findings in current study. Hyperinsulinemia caused by insulin resistance is one of the complications associated with MS, which puts individuals at risk of diabetes and cardiovascular events.

Results

Uric acid level in the Case group was significantly higher than the control group (p = 0.0001, 43.8±1.4 vs. 4.1±1 mg/dl, respectively). Insulin level was significantly higher in the case group in compare to the control group (p = 0.008, 9.8± 5.3 vs. 12.2±6 μU/ml, respectively).

Conclusion

The findings of this case-control study showed that adolescents with metabolic syndrome have a higher uric acid and insulin level in compare to normal subjects. We hypothesis that increase in serum insulin and uric acid level can be a risk factor in the development of metabolic syndrome.

     

Serum lipid resistance to oxidation and uric acid levels in subjects with Down's syndrome

In subjects with Down's syndrome (DS) increased oxidative stress and consequent oxidative cell damage have been reported. The aim of this study was to assess whether the excessive production of free oxygen radicals in these subjects can affect the copper-induced lipid oxidation resistance measured in fresh whole serum. Since a significant elevation of serum uric acid levels, which is an efficient hydrophilic antioxidant, has been repeatedly reported in subjects with DS, we studied the association between increased serum uric acid levels and lipid resistance to oxidation measured directly in serum samples by monitoring the change in absorbance at 234 nm. The group of subjects with Down's syndrome consisted of 25 individuals (aged 18+/-5 years). Control group included brothers and sisters of subjects with DS (n = 25, aged 17+/-7 years). In subjects with DS, the serum lipid resistance to oxidation (lag time) was significantly higher than in controls (p<0.05) and a concomitant increase in serum uric acid levels was observed (p<0.001). A significant positive correlation between lag time and serum uric acid concentration was found in subjects with DS (r = 0.48, p<0.05), while the positive correlation in the control group was not significant. The results suggest that increased serum uric acid levels repeatedly observed in subjects with DS may be associated with an enhanced resistance of serum lipids to oxidation which is thought to play an important role in the atherogenic process.     

Serum uric acid: not a discriminator of coronary heart disease in men and women

Fasting serum uric acid (SUA) was measured using a spectrophotometric method in 635 randomized male subjects aged 20 to 70, as part of an epidemiological study carried our among the civil employees of French origin working for the City of Montreal. It was observed that SUA was not age-dependent and that the overall mean value was 6.26 mg./100 ml. On the other hand SUA was studied in 742 males and 260 females, all of whom had had coronarography. A significant difference in SUA between males and females of 1.26 mg./100 ml. was noted. Correlating the SUA levels with the incidence of CHD or the severity of the lesions in the coronary arteries indicated no relationship between CHD and SUA concentrations in men or in women. The results of this study permit the conclusion that SUA is not a discriminator for CHD.