共查询到20条相似文献,搜索用时 0 毫秒
1.
2.
Systemic Lupus Erythematosus (SLE) is one of the most relevant world-wide autoimmune disorders. The formation of autoantibodies and the deposition of antibody-containing immune complexes in blood vessels throughout the body is the main pathogenic mechanism of SLE leading to heterogeneous clinical manifestations and target tissue damage. The complexity of etiology and pathogenesis in SLE, enclosing genetic and environmental factors, apparently is one of the greatest challenges for both researchers and clinicians. Strong indications for a genetic background in SLE come from studies in families as well as in monozygotic and dizygotic twins, discovering several SLE-associated loci and genes (e.g. IRF5, PTPN22, CTLA4, STAT4 and BANK1). As SLE has a complex genetic background, none of these genes is likely to be entirely responsible for triggering autoimmune response in SLE even if they disclosure a potentially novel molecular mechanisms in the pathogenesis'' disease. The clinical manifestations and disease severity varies greatly among patients, thus several studies try to associate clinical heterogeneity and prognosis with specific genetic polymorphisms in SLE associated genes. The continue effort to describe new predisposing or modulating genes in SLE is justified by the limited knowledge about the pathogenesis, assorted clinical manifestation and the possible prevention strategies. In this review we describe newly discovered, as well as the most studied genes associated to SLE susceptibility, and relate them to clinical manifestations of the disease. 相似文献
3.
4.
5.
6.
Sidney W. Mintz 《The Yale journal of biology and medicine》1957,29(4):464-465
7.
8.
9.
Object Oriented Data Analysis is a new area in statistics that studies populations of general data objects. In this article
we consider populations of tree-structured objects as our focus of interest. We develop improved analysis tools for data lying
in a binary tree space analogous to classical Principal Component Analysis methods in Euclidean space. Our extensions of PCA
are analogs of one dimensional subspaces that best fit the data. Previous work was based on the notion of tree-lines. 相似文献
10.
11.
Flavonoids are ubiquitous in the plant kingdom and have many diverse functions including defense, UV protection, auxin transport inhibition, allelopathy, and flower coloring. Interestingly, these compounds also have considerable biological activity in plant, animal and bacterial systems-such broad activity is accomplished by few compounds. Yet, for all the research over the last three decades, many of the cellular targets of these secondary metabolites are unknown. The many mutants available in model plant ... 相似文献
12.
13.
14.
15.
16.
17.
Kai Larsen 《Nordic Journal of Botany》1996,16(4):366-366
Poole. A. L. & Adams, N. M. 1994. Trees and shrubs of New Zealand. - Manaaki Whenua Press. Lincoln, New Zealand. ISBN 0–478–04535–2. 256 pages. Price: 30 USD 相似文献
18.
New Roles for MADS-box Genes in Higher Plants 总被引:4,自引:0,他引:4
F. García-Maroto M.-J. Carmona J.-A. Garrido M. Vilches-Ferrón J. Rodríguez-Ruiz D. López Alonso 《Biologia Plantarum》2003,46(3):321-330
19.
Two new approaches to detecting potential incongruence between a protein family tree and a species tree are considered. The first approach is based on the substitution of a known mapping of the gene tree G into the species tree S with a somewhat analogous multivalued G-into-S mapping. The second approach is based on the elementary concepts of the fuzzy set theory. Two algorithms corresponding to these approaches are described in detail, and their implementation is shown using a simulation example and three protein families from the database of clusters of orthologous protein groups (COGs). 相似文献