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Multiple mechanisms and functions of maf transcription factors in the regulation of tissue-specific genes 总被引:2,自引:0,他引:2
Kataoka K 《Journal of biochemistry》2007,141(6):775-781
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Transcription factor cycling on the insulin promoter 总被引:2,自引:0,他引:2
Using MIN6 beta-cells and chromatin immunoprecipitation (ChIP) assays, the chronological sequence of binding of MafA, E47/beta2 and PDX-1 to the insulin promoter in living beta-cells were investigated. All four factors were shown to bind to the mouse insulin 2 promoter in a cyclical manner with a periodicity of approximately 10-15 min. The cyclical binding of MafA, E47 and beta2 was largely unaffected by the glucose or insulin concentration in the media. However, the binding and cycling of PDX-1 was markedly abolished in low glucose (1 mM), and this was reversed in the presence of low concentrations of insulin. 相似文献
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Ptf1a binds to and activates area III, a highly conserved region of the Pdx1 promoter that mediates early pancreas-wide Pdx1 expression 总被引:3,自引:0,他引:3 下载免费PDF全文
Wiebe PO Kormish JD Roper VT Fujitani Y Alston NI Zaret KS Wright CV Stein RW Gannon M 《Molecular and cellular biology》2007,27(11):4093-4104
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The islet beta cell-enriched MafA activator is a key regulator of insulin gene transcription 总被引:13,自引:0,他引:13
Zhao L Guo M Matsuoka TA Hagman DK Parazzoli SD Poitout V Stein R 《The Journal of biological chemistry》2005,280(12):11887-11894
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