共查询到20条相似文献,搜索用时 15 毫秒
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Smith L Brannan RA Hanby AM Shaaban AM Verghese ET Peter MB Pollock S Satheesha S Szynkiewicz M Speirs V Hughes TA 《Journal of cellular and molecular medicine》2010,14(8):2172-2184
Oestrogen receptors (ERs) are critical regulators of the behaviour of many cancers. Despite this, the roles and regulation of one of the two known ERs - ERβ- are poorly understood. This is partly because analyses have been confused by discrepancies between ERβ expression at mRNA and proteins levels, and because ERβ is expressed as several functionally distinct isoforms. We investigated human ERβ 5' untranslated regions (UTRs) and their influences on ERβ expression and function. We demonstrate that two alternative ERβ 5'UTRs have potent and differential influences on expression acting at the level of translation. We show that their influences are modulated by cellular context and in carcinogenesis, and demonstrate the contributions of both upstream open reading frames and RNA secondary structure. These regulatory mechanisms offer explanations for the non-concordance of ERβ mRNA and protein. Importantly, we also demonstrate that 5'UTRs allow the first reported mechanisms for differential regulation of the expression of the ERβ isoforms 1, 2 and 5, and thereby have critical influences on ERβ function. 相似文献
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Extra-nuclear signaling of estrogen receptors 总被引:1,自引:0,他引:1
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Integration of the extranuclear and nuclear actions of estrogen 总被引:21,自引:0,他引:21
Levin ER 《Molecular endocrinology (Baltimore, Md.)》2005,19(8):1951-1959
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The estrogen receptor enhances AP-1 activity by two distinct mechanisms with different requirements for receptor transactivation functions. 总被引:13,自引:0,他引:13
P Webb P Nguyen C Valentine G N Lopez G R Kwok E McInerney B S Katzenellenbogen E Enmark J A Gustafsson S Nilsson P J Kushner 《Molecular endocrinology (Baltimore, Md.)》1999,13(10):1672-1685
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Role of Id family proteins in growth control. 总被引:29,自引:0,他引:29
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