A Ca2+-Dependent Switch Activates Axonal Casein Kinase 2α Translation and Drives G3BP1 Granule Disassembly for Axon Regeneration

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Pharmacological Activation of Pyruvate Kinase M2 Inhibits CD4+ T Cell Pathogenicity and Suppresses Autoimmunity

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Secreted Pyruvate Kinase M2 Promotes Lung Cancer Metastasis through Activating the Integrin Beta1/FAK Signaling Pathway

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TORC1 Determines Fab1 Lipid Kinase Function at Signaling Endosomes and Vacuoles

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Lysine acetylation restricts mutant IDH2 activity to optimize transformation in AML cells

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Salt Sensing by Serum/Glucocorticoid-Regulated Kinase 1 Promotes Th17-like Inflammatory Adaptation of Foxp3+ Regulatory T Cells

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Histone H2AK119 Mono-Ubiquitination Is Essential for Polycomb-Mediated Transcriptional Repression

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The Salmonella Secreted Effector SarA/SteE Mimics Cytokine Receptor Signaling to Activate STAT3

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Targeting EphA2 suppresses hepatocellular carcinoma initiation and progression by dual inhibition of JAK1/STAT3 and AKT signaling

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CpG island reconfiguration for the establishment and synchronization of polycomb functions upon exit from naive pluripotency

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Structural Basis for the Activation and Target Site Specificity of CDC7 Kinase

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PALI1 promotes tumor growth through competitive recruitment of PRC2 to G9A-target chromatin for dual epigenetic silencing

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An epithelial-immune circuit amplifies inflammasome and IL-6 responses to SARS-CoV-2

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Competition between PRC2.1 and 2.2 subcomplexes regulates PRC2 chromatin occupancy in human stem cells

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SETDB1-Mediated Cell Fate Transition between 2C-Like and Pluripotent States

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Atomic insights into ML-SI3 mediated human TRPML1 inhibition

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TIR domains of plant immune receptors are 2′,3′-cAMP/cGMP synthetases mediating cell death

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PRC2.1- and PRC2.2-specific accessory proteins drive recruitment of different forms of canonical PRC1

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The Arabidopsis Receptor Kinase IRK Is Polarized and Represses Specific Cell Divisions in Roots

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The LKB1-like Kinase Elm1 Controls Septin Hourglass Assembly and Stability by Regulating Filament Pairing

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