Lysine acetylation restricts mutant IDH2 activity to optimize transformation in AML cells

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Histone H2AK119 Mono-Ubiquitination Is Essential for Polycomb-Mediated Transcriptional Repression

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Salmonella Effector SteE Converts the Mammalian Serine/Threonine Kinase GSK3 into a Tyrosine Kinase to Direct Macrophage Polarization

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Targeting EphA2 suppresses hepatocellular carcinoma initiation and progression by dual inhibition of JAK1/STAT3 and AKT signaling

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PALI1 promotes tumor growth through competitive recruitment of PRC2 to G9A-target chromatin for dual epigenetic silencing

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CpG island reconfiguration for the establishment and synchronization of polycomb functions upon exit from naive pluripotency

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Competition between PRC2.1 and 2.2 subcomplexes regulates PRC2 chromatin occupancy in human stem cells

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Atomic insights into ML-SI3 mediated human TRPML1 inhibition

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An epithelial-immune circuit amplifies inflammasome and IL-6 responses to SARS-CoV-2

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SETDB1-Mediated Cell Fate Transition between 2C-Like and Pluripotent States

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TIR domains of plant immune receptors are 2′,3′-cAMP/cGMP synthetases mediating cell death

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PRC2.1- and PRC2.2-specific accessory proteins drive recruitment of different forms of canonical PRC1

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E6AP AZUL interaction with UBQLN1/2 in cells,condensates, and an AlphaFold-NMR integrated structure

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Bipartite binding of the N terminus of Skp2 to cyclin A

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The Polycomb group protein MEDEA controls cell proliferation and embryonic patterning in Arabidopsis

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Histone H3.3 K27M and K36M mutations de-repress transposable elements through perturbation of antagonistic chromatin marks

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Systematic reconstruction of an effector-gene network reveals determinants of Salmonella cellular and tissue tropism

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Monoallelic intragenic POU3F2 variants lead to neurodevelopmental delay and hyperphagic obesity,confirming the gene’s candidacy in 6q16.1 deletions

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A calmodulin-binding transcription factor links calcium signaling to antiviral RNAi defense in plants

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TET2 is a component of the estrogen receptor complex and controls 5mC to 5hmC conversion at estrogen receptor cis-regulatory regions

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